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The map label for this gene is fdh [H]

Identifier: 17228392

GI number: 17228392

Start: 1035420

End: 1036589

Strand: Direct

Name: fdh [H]

Synonym: alr0897

Alternate gene names: 17228392

Gene position: 1035420-1036589 (Clockwise)

Preceding gene: 17228391

Following gene: 17228393

Centisome position: 16.14

GC content: 44.96

Gene sequence:

>1170_bases
ATGAAAGCAGTTTGCTGGCACGGGACAAATGATGTCAGGGTAGAAACTGTACCCGATCCAAAAATTCTTAACCCGCGCGA
CGCAATTATTAAAATTACTTCTACAGCTATTTGTGGGTCTGATTTACATATATATAATGGCTATATTCCCACAATGCAAA
GTGGCGATATCCTTGGTCATGAATTCATGGGGGAAGTTGTCGAGTTAGGTAGTGCTGTAAAAAATGTGAAAGTAGGCGAT
CGCGTCGTTGTTCCTTTTACCATTTCCTGCGGTTCTTGCTTCTTCTGTCAACGGGATTTATGGTCTTTGTGCGATAACTC
CAACCCCAACGCCTGGCTGGTAGAACTGCAAATGGGTCATTCTCCAGCAGGTCTATTTGGCTACTCTCACCTATTTGGTG
GCTATGCTGGGGGTCAAGCAGAATACGCCCGTGTACCTTTTGCAGATGTCGGCTTGCTTAAAATTCCTGATAATCTACCA
GATGAACAGGTATTATTTTTAACTGATATTTTTCCCACTGGCTACATGGCGGCGGAGAACTGTAATATCAAACCCGGCGA
TATTGTGGCTGTGTGGGGTTGTGGCCCCGTTGGACAATTTGCTATCAAAAGTGCATATATGTTGGGTGCGGAAAGAGTTA
TCGCCTTTGACCGCATCCCCGAACGCCTACAAATGGCTAAAGAACAATGTAATGCCGAAGTCCTCAATTACGAAGAGGTA
AATATCGGGGAAGCACTCAAAGAGATGACTGGTGGACGCGGCCCTGATGCTTGTATTGATGCGGTAGGCATGGAAGCCCA
CGGTACAGACTTAATGGCTTTCTACGACCAAGTCAAGCAAGCTGTAAGACTAGAAACAGACAGACCAACAGCATTACGAC
AAGTGATTGTGTCTGCGGCTAAAGGTGGTCATGTTTCTCTGGCGGGTGTATATGGCGGTTTCCTGGACAAAATCCCGATG
GGTTCAGCGATGAATAAGGGTTTAACCTTCAAGATGGGACAAACCCATGTCCATAAATACTTAAAACCCTTACTAGAACG
TATTCAAAACGGTGAAATTGACCCCTCATTTGTCATCACCCACACCATCCCGCTAGAACAAGCACCCCACGGCTACGAAA
TTTTTAAACACAAAAAAGATAACTGCATCAAAGTTGTACTCAAACCCTAA

Upstream 100 bases:

>100_bases
TTAATAAACTGTGGGTATTCAGATCCCCGATTTTTTAAAAAGTCGGGGATCTATGACCTGAATCTAGAGATAAAAAATTA
ATGCCCAAGGACTAATAAAT

Downstream 100 bases:

>100_bases
GGTAATTAAATATGAGCGACACTAGCGTCAAAAAAATAGACTCTCACCATTCCCCCAAAGGTAAACTCGGTCAGAAATAT
TTAGCATCTGGCAAATCTAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKAVCWHGTNDVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYNGYIPTMQSGDILGHEFMGEVVELGSAVKNVKVGD
RVVVPFTISCGSCFFCQRDLWSLCDNSNPNAWLVELQMGHSPAGLFGYSHLFGGYAGGQAEYARVPFADVGLLKIPDNLP
DEQVLFLTDIFPTGYMAAENCNIKPGDIVAVWGCGPVGQFAIKSAYMLGAERVIAFDRIPERLQMAKEQCNAEVLNYEEV
NIGEALKEMTGGRGPDACIDAVGMEAHGTDLMAFYDQVKQAVRLETDRPTALRQVIVSAAKGGHVSLAGVYGGFLDKIPM
GSAMNKGLTFKMGQTHVHKYLKPLLERIQNGEIDPSFVITHTIPLEQAPHGYEIFKHKKDNCIKVVLKP

Sequences:

>Translated_389_residues
MKAVCWHGTNDVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYNGYIPTMQSGDILGHEFMGEVVELGSAVKNVKVGD
RVVVPFTISCGSCFFCQRDLWSLCDNSNPNAWLVELQMGHSPAGLFGYSHLFGGYAGGQAEYARVPFADVGLLKIPDNLP
DEQVLFLTDIFPTGYMAAENCNIKPGDIVAVWGCGPVGQFAIKSAYMLGAERVIAFDRIPERLQMAKEQCNAEVLNYEEV
NIGEALKEMTGGRGPDACIDAVGMEAHGTDLMAFYDQVKQAVRLETDRPTALRQVIVSAAKGGHVSLAGVYGGFLDKIPM
GSAMNKGLTFKMGQTHVHKYLKPLLERIQNGEIDPSFVITHTIPLEQAPHGYEIFKHKKDNCIKVVLKP
>Mature_389_residues
MKAVCWHGTNDVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYNGYIPTMQSGDILGHEFMGEVVELGSAVKNVKVGD
RVVVPFTISCGSCFFCQRDLWSLCDNSNPNAWLVELQMGHSPAGLFGYSHLFGGYAGGQAEYARVPFADVGLLKIPDNLP
DEQVLFLTDIFPTGYMAAENCNIKPGDIVAVWGCGPVGQFAIKSAYMLGAERVIAFDRIPERLQMAKEQCNAEVLNYEEV
NIGEALKEMTGGRGPDACIDAVGMEAHGTDLMAFYDQVKQAVRLETDRPTALRQVIVSAAKGGHVSLAGVYGGFLDKIPM
GSAMNKGLTFKMGQTHVHKYLKPLLERIQNGEIDPSFVITHTIPLEQAPHGYEIFKHKKDNCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=395, Percent_Identity=28.1012658227848, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=395, Percent_Identity=27.0886075949367, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156523966, Length=379, Percent_Identity=26.9129287598945, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565154, Length=266, Percent_Identity=32.3308270676692, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=26.6846361185984, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501929, Length=271, Percent_Identity=33.9483394833948, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4501933, Length=394, Percent_Identity=26.6497461928934, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=49.1094147582697, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790045, Length=377, Percent_Identity=28.6472148541114, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787863, Length=390, Percent_Identity=25.6410256410256, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082125, Length=392, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788073, Length=386, Percent_Identity=24.8704663212435, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788075, Length=383, Percent_Identity=25.8485639686684, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=237, Percent_Identity=27.4261603375527, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=233, Percent_Identity=32.1888412017167, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=26.4864864864865, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=247, Percent_Identity=29.5546558704453, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=215, Percent_Identity=26.046511627907, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=389, Percent_Identity=24.9357326478149, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=250, Percent_Identity=31.6, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=27.0676691729323, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=250, Percent_Identity=31.2, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=225, Percent_Identity=29.7777777777778, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=400, Percent_Identity=29, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=415, Percent_Identity=25.7831325301205, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=279, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=279, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=312, Percent_Identity=26.6025641025641, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=254, Percent_Identity=27.1653543307087, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=271, Percent_Identity=28.4132841328413, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737895, Length=395, Percent_Identity=27.3417721518987, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737897, Length=392, Percent_Identity=22.9591836734694, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551930, Length=216, Percent_Identity=28.7037037037037, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221457811, Length=216, Percent_Identity=28.7037037037037, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550770, Length=216, Percent_Identity=28.7037037037037, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42501; Mature: 42501

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVCWHGTNDVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYNGYIPTMQSGDILGH
CCEEEEECCCCEEEEECCCCCCCCCCCCEEEEEEHEECCCCEEEECCCCCCCCCCCCCCH
EFMGEVVELGSAVKNVKVGDRVVVPFTISCGSCFFCQRDLWSLCDNSNPNAWLVELQMGH
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCEEEEEEEECC
SPAGLFGYSHLFGGYAGGQAEYARVPFADVGLLKIPDNLPDEQVLFLTDIFPTGYMAAEN
CCCCHHHHHHHHCCCCCCCCCEEECCCCCCCEEECCCCCCCCEEEEEEECCCCCCEEECC
CNIKPGDIVAVWGCGPVGQFAIKSAYMLGAERVIAFDRIPERLQMAKEQCNAEVLNYEEV
CCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHEEEHHHCHHHHHHHHHHCCCEEECCCCC
NIGEALKEMTGGRGPDACIDAVGMEAHGTDLMAFYDQVKQAVRLETDRPTALRQVIVSAA
CHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
KGGHVSLAGVYGGFLDKIPMGSAMNKGLTFKMGQTHVHKYLKPLLERIQNGEIDPSFVIT
CCCCEEEEHHHHHHHHHCCCCCHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEE
HTIPLEQAPHGYEIFKHKKDNCIKVVLKP
EEECCCCCCCCHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKAVCWHGTNDVRVETVPDPKILNPRDAIIKITSTAICGSDLHIYNGYIPTMQSGDILGH
CCEEEEECCCCEEEEECCCCCCCCCCCCEEEEEEHEECCCCEEEECCCCCCCCCCCCCCH
EFMGEVVELGSAVKNVKVGDRVVVPFTISCGSCFFCQRDLWSLCDNSNPNAWLVELQMGH
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCCCCEEEEEEEECC
SPAGLFGYSHLFGGYAGGQAEYARVPFADVGLLKIPDNLPDEQVLFLTDIFPTGYMAAEN
CCCCHHHHHHHHCCCCCCCCCEEECCCCCCCEEECCCCCCCCEEEEEEECCCCCCEEECC
CNIKPGDIVAVWGCGPVGQFAIKSAYMLGAERVIAFDRIPERLQMAKEQCNAEVLNYEEV
CCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHEEEHHHCHHHHHHHHHHCCCEEECCCCC
NIGEALKEMTGGRGPDACIDAVGMEAHGTDLMAFYDQVKQAVRLETDRPTALRQVIVSAA
CHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
KGGHVSLAGVYGGFLDKIPMGSAMNKGLTFKMGQTHVHKYLKPLLERIQNGEIDPSFVIT
CCCCEEEEHHHHHHHHHCCCCCHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEE
HTIPLEQAPHGYEIFKHKKDNCIKVVLKP
EEECCCCCCCCHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]