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The map label for this gene is ytpA [H]

Identifier: 17228346

GI number: 17228346

Start: 978239

End: 979084

Strand: Direct

Name: ytpA [H]

Synonym: alr0851

Alternate gene names: 17228346

Gene position: 978239-979084 (Clockwise)

Preceding gene: 17228344

Following gene: 17228350

Centisome position: 15.25

GC content: 45.86

Gene sequence:

>846_bases
ATGGTCTACCATAACGAAGGCGTATTTAAAAGTGTCGATGGACTTGAGCTTTATTATCAGAATTGGTATCCAGAAGTTAA
AGCAAAAGCCATCTTGGTGATTGTGCATGGACTGGGAGGACACAGTGATAAATATAGTAATATCGTCAACCATCTAACAG
CCAAAGATTATGCCGTTTATGGCTTAGATTTACGCGGTCATGGGCGATCGCCTGGACAGCGTGGTCACATCAACGCCTGG
GCTGATTTTCGGGGAGATTTAAGTGCTTTCTTAGAGCTAATTCAGACCCAGCAGCCACAATCCCCGATTTTCTTATTAGG
GCATAGTTTAGGTGCAGTAGTTGTCTGCGACTATATTTTACGCTGTCCCAAAGAAGCCGCAAAATTGCAAGGTGCGATCG
CCTTAGCACCAGCCATAGGCAAAGTCGGCGTGTCGAAATTCCGCTTACTTGTAGGTAAATTGCTTTCGCAAATATGGCCG
CGCTTCTCCTTAACTACTGGACTTGACCTGAGTGCAGGTTCACGAGACGAGAAAGTTGTAGCCGCTTATGCTCAAGACAC
CCTACGCCATAATCTTGGTAGCGCCCGTTTAGCCACAGAATACTTTACCACCGTCGCCTGGATTCATGCTCATGCACCTG
ACTGGCAAATCCCCTTGCTGATTCTTCACGGTAGCAGCGATCGCATCGCCTCACCTGAAGGCGGAGAAATTTTTTACAAA
AACGTAGGTTGTTCAGATAAGTTTCGTATCGAATACCCGGAAGCCTATCATGACCTACAAGCAGACCTCAACTACCAACA
AGTCCTAGCTGACATAGAAAATTGGCTAGAAAATCATTTGCCATAA

Upstream 100 bases:

>100_bases
GAAGTTTGCGGAAAGTGGGCGGTGTCGGTTTCCGTCCCGCCCAACTTTCCAAGACGAATTTTGTAGCTTTAGCTTCCCGT
AGGGTATTTTTAATTAATTC

Downstream 100 bases:

>100_bases
ATGCTTCCCCTGCTTCCCCTGCTTCCCAAGGCGATTGGATATTTCTTAGTGAGAATTCCCTTCTTCTGTCCCAAGCCCGA
AAATTTTTTTCCCGACCTAT

Product: lysophospholipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MVYHNEGVFKSVDGLELYYQNWYPEVKAKAILVIVHGLGGHSDKYSNIVNHLTAKDYAVYGLDLRGHGRSPGQRGHINAW
ADFRGDLSAFLELIQTQQPQSPIFLLGHSLGAVVVCDYILRCPKEAAKLQGAIALAPAIGKVGVSKFRLLVGKLLSQIWP
RFSLTTGLDLSAGSRDEKVVAAYAQDTLRHNLGSARLATEYFTTVAWIHAHAPDWQIPLLILHGSSDRIASPEGGEIFYK
NVGCSDKFRIEYPEAYHDLQADLNYQQVLADIENWLENHLP

Sequences:

>Translated_281_residues
MVYHNEGVFKSVDGLELYYQNWYPEVKAKAILVIVHGLGGHSDKYSNIVNHLTAKDYAVYGLDLRGHGRSPGQRGHINAW
ADFRGDLSAFLELIQTQQPQSPIFLLGHSLGAVVVCDYILRCPKEAAKLQGAIALAPAIGKVGVSKFRLLVGKLLSQIWP
RFSLTTGLDLSAGSRDEKVVAAYAQDTLRHNLGSARLATEYFTTVAWIHAHAPDWQIPLLILHGSSDRIASPEGGEIFYK
NVGCSDKFRIEYPEAYHDLQADLNYQQVLADIENWLENHLP
>Mature_281_residues
MVYHNEGVFKSVDGLELYYQNWYPEVKAKAILVIVHGLGGHSDKYSNIVNHLTAKDYAVYGLDLRGHGRSPGQRGHINAW
ADFRGDLSAFLELIQTQQPQSPIFLLGHSLGAVVVCDYILRCPKEAAKLQGAIALAPAIGKVGVSKFRLLVGKLLSQIWP
RFSLTTGLDLSAGSRDEKVVAAYAQDTLRHNLGSARLATEYFTTVAWIHAHAPDWQIPLLILHGSSDRIASPEGGEIFYK
NVGCSDKFRIEYPEAYHDLQADLNYQQVLADIENWLENHLP

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=273, Percent_Identity=27.8388278388278, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI6005786, Length=271, Percent_Identity=28.0442804428044, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787678, Length=279, Percent_Identity=23.2974910394265, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322756, Length=293, Percent_Identity=26.962457337884, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31233; Mature: 31233

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYHNEGVFKSVDGLELYYQNWYPEVKAKAILVIVHGLGGHSDKYSNIVNHLTAKDYAVY
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEE
GLDLRGHGRSPGQRGHINAWADFRGDLSAFLELIQTQQPQSPIFLLGHSLGAVVVCDYIL
EEEEECCCCCCCCCCCCEEHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
RCPKEAAKLQGAIALAPAIGKVGVSKFRLLVGKLLSQIWPRFSLTTGLDLSAGSRDEKVV
HCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHH
AAYAQDTLRHNLGSARLATEYFTTVAWIHAHAPDWQIPLLILHGSSDRIASPEGGEIFYK
HHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEE
NVGCSDKFRIEYPEAYHDLQADLNYQQVLADIENWLENHLP
ECCCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVYHNEGVFKSVDGLELYYQNWYPEVKAKAILVIVHGLGGHSDKYSNIVNHLTAKDYAVY
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEE
GLDLRGHGRSPGQRGHINAWADFRGDLSAFLELIQTQQPQSPIFLLGHSLGAVVVCDYIL
EEEEECCCCCCCCCCCCEEHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
RCPKEAAKLQGAIALAPAIGKVGVSKFRLLVGKLLSQIWPRFSLTTGLDLSAGSRDEKVV
HCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHH
AAYAQDTLRHNLGSARLATEYFTTVAWIHAHAPDWQIPLLILHGSSDRIASPEGGEIFYK
HHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEE
NVGCSDKFRIEYPEAYHDLQADLNYQQVLADIENWLENHLP
ECCCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]