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The map label for this gene is dnaX [H]

Identifier: 170762399

GI number: 170762399

Start: 105788

End: 107581

Strand: Direct

Name: dnaX [H]

Synonym: UPA3_0087

Alternate gene names: 170762399

Gene position: 105788-107581 (Clockwise)

Preceding gene: 170761917

Following gene: 170762369

Centisome position: 14.07

GC content: 22.69

Gene sequence:

>1794_bases
ATGAGCGAATCAACATTGTACCGTAAATATCGGCCACATAAATTTAAAAATGTAATAGGTCAAGATTTAATTAAACAAGC
ATTAATGAATGCTTGTTTAAACAACAAAATTACACATGCTTATATTTTTAGTGGACCACGAGGAATTGGAAAAACATCAA
TAGCTAGAATTTTTGCGTCTAGTATTAATTGTTTAAATCCTAATAAAGGTGATTGTTGCGGCAAATGTAGTGTTTGTGAA
AGTATTCTCAAAGAACAAAGTGTTGATTTGATTGAATTAGATGCTGCTAGTAATAATGGTGTTGATCAAATACGTATTAT
TACTGATAATATAAATTATTTACCAACATTTTTTAAGTATAAAGTCTATATTATTGATGAAGCACATATGCTATCTACAT
CAGCATGAAATGCTTTATTAAAAACAGTTGAAGAACCACCACAACACGTTATTTTTATTTTTGCAACAACAGAGTACCAA
AAAATTCCCTTAACAATTATTAGTCGTTGCCAACGTTATGATTTTAAGCGTTTAAATAACAGTGAATTACAAGAATTAAT
AGACTCTATCCTTACAAAAGAAGATATCAAAATTGATAATAATGCAATTGATAAATTAATTCAATTAGCTGATGGATCTG
GGCGTGATTGTTTAAGCATTTTAGATCAATTAACAACGGTTAAAAAAAATATAGATCTTGATTTAATAAATAAAACTTTT
GGTTTAGTTGACAACTTTAAAGTAATTTCTTTAATCGAATTAATTCAAAAAAACGACATTTTATTATTGCGTGAATTTAT
TTATGAATTATACAATCAAGGTGTTAATTTAGAAGCTTTTTGTGTGCAAATAATAAATGTTTTAATTGATTATTTAATTT
ATTTAAAAACAAACGATATAAATAATCTTAAAAAAGTATCAGTTGATGAATTAAAAAAAATGTTATTAATTAATTTTAAT
GGTAATTATTTGTTAAATAATTTTATTTCTTTATTTAATAATTTAAAAAAATCATTAAATCAAGTTTTTGAATTTGAAAT
TTATTTATATAAAATAATCAATGCTAATAATGATAAATTAGAAAATAAAAAAATAGAATTGTCAATTAACCCTGAAGAAA
ATAAAATTAATAATTCCCAAATAATAACGACAAAAAAAATCGATTGTTTTGAAGAAATAAATAAAAATACTGTTGATTTT
GATAAGTTATACAAAACAAAAATTTTTTATCACAAAAAAATTAACAACCAGAATGATAAAGAATCAGGTATTAATCAAAA
AGAAGAATTAAGTACAGAATTAGTTAATGATAATAAATTGATTTGCAATTCTAATGATATATTAGATAATTATGAACTAG
CCAAACAAGCTTTTTTTAATAAAGACATTAAACTTTCAAAAGAAATGAGTCAAAAATTTAAAGATTTTAAAAATGAAGAA
ACCATTGAAAATAGTTATATTGATATTATTAAACAAGCTGATTTAGTACTTTGGTGCTCACCTAATGCACTAGTTTTAGG
AGTAGAGTTTTTAGGATTAATTAATCGTATCAATAAAGTTACGCATTCATTTGAATTTATTAAAGAATTTGTTAAGAAAT
TTGATTCTATCAAGTTAGTTATTGCTATTAGCAAAAAACAAGCATTAAATATTATTAATATTAAAAAACAAGGTTTAAAA
ACTAATATAATTAATGATGTTTTAATTGATGATATTAAAATGTTATTAAAACAAGAAGAACAACGAAAACAAGAACAAAC
AGCGTTATTAAATGAAATTGAAGATGAGGAGTAA

Upstream 100 bases:

>100_bases
TTAAAAAATGTTAATTTTATGGTATTTATAATAGATAAAAATTAAATTTTGTGCTAATTCTAATTTATAATTAAAACTAG
TAGTTTTTAGGGGATAATAA

Downstream 100 bases:

>100_bases
AATTTAAATGGACTTTCAAAAACTTGCACAAGAATTAAAAAAAATGCAAAACACTTTAAGTAAAAAACAAAAAGAATTTG
AAGAAAAAGTGTTTGATTTT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSESTLYRKYRPHKFKNVIGQDLIKQALMNACLNNKITHAYIFSGPRGIGKTSIARIFASSINCLNPNKGDCCGKCSVCE
SILKEQSVDLIELDAASNNGVDQIRIITDNINYLPTFFKYKVYIIDEAHMLSTSAWNALLKTVEEPPQHVIFIFATTEYQ
KIPLTIISRCQRYDFKRLNNSELQELIDSILTKEDIKIDNNAIDKLIQLADGSGRDCLSILDQLTTVKKNIDLDLINKTF
GLVDNFKVISLIELIQKNDILLLREFIYELYNQGVNLEAFCVQIINVLIDYLIYLKTNDINNLKKVSVDELKKMLLINFN
GNYLLNNFISLFNNLKKSLNQVFEFEIYLYKIINANNDKLENKKIELSINPEENKINNSQIITTKKIDCFEEINKNTVDF
DKLYKTKIFYHKKINNQNDKESGINQKEELSTELVNDNKLICNSNDILDNYELAKQAFFNKDIKLSKEMSQKFKDFKNEE
TIENSYIDIIKQADLVLWCSPNALVLGVEFLGLINRINKVTHSFEFIKEFVKKFDSIKLVIAISKKQALNIINIKKQGLK
TNIINDVLIDDIKMLLKQEEQRKQEQTALLNEIEDEE

Sequences:

>Translated_597_residues
MSESTLYRKYRPHKFKNVIGQDLIKQALMNACLNNKITHAYIFSGPRGIGKTSIARIFASSINCLNPNKGDCCGKCSVCE
SILKEQSVDLIELDAASNNGVDQIRIITDNINYLPTFFKYKVYIIDEAHMLSTSA*NALLKTVEEPPQHVIFIFATTEYQ
KIPLTIISRCQRYDFKRLNNSELQELIDSILTKEDIKIDNNAIDKLIQLADGSGRDCLSILDQLTTVKKNIDLDLINKTF
GLVDNFKVISLIELIQKNDILLLREFIYELYNQGVNLEAFCVQIINVLIDYLIYLKTNDINNLKKVSVDELKKMLLINFN
GNYLLNNFISLFNNLKKSLNQVFEFEIYLYKIINANNDKLENKKIELSINPEENKINNSQIITTKKIDCFEEINKNTVDF
DKLYKTKIFYHKKINNQNDKESGINQKEELSTELVNDNKLICNSNDILDNYELAKQAFFNKDIKLSKEMSQKFKDFKNEE
TIENSYIDIIKQADLVLWCSPNALVLGVEFLGLINRINKVTHSFEFIKEFVKKFDSIKLVIAISKKQALNIINIKKQGLK
TNIINDVLIDDIKMLLKQEEQRKQEQTALLNEIEDEE
>Mature_596_residues
SESTLYRKYRPHKFKNVIGQDLIKQALMNACLNNKITHAYIFSGPRGIGKTSIARIFASSINCLNPNKGDCCGKCSVCES
ILKEQSVDLIELDAASNNGVDQIRIITDNINYLPTFFKYKVYIIDEAHMLSTSA*NALLKTVEEPPQHVIFIFATTEYQK
IPLTIISRCQRYDFKRLNNSELQELIDSILTKEDIKIDNNAIDKLIQLADGSGRDCLSILDQLTTVKKNIDLDLINKTFG
LVDNFKVISLIELIQKNDILLLREFIYELYNQGVNLEAFCVQIINVLIDYLIYLKTNDINNLKKVSVDELKKMLLINFNG
NYLLNNFISLFNNLKKSLNQVFEFEIYLYKIINANNDKLENKKIELSINPEENKINNSQIITTKKIDCFEEINKNTVDFD
KLYKTKIFYHKKINNQNDKESGINQKEELSTELVNDNKLICNSNDILDNYELAKQAFFNKDIKLSKEMSQKFKDFKNEET
IENSYIDIIKQADLVLWCSPNALVLGVEFLGLINRINKVTHSFEFIKEFVKKFDSIKLVIAISKKQALNIINIKKQGLKT
NIINDVLIDDIKMLLKQEEQRKQEQTALLNEIEDEE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=303, Percent_Identity=24.7524752475248, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI31881687, Length=303, Percent_Identity=24.7524752475248, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI194306571, Length=218, Percent_Identity=25.6880733944954, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI194306567, Length=218, Percent_Identity=25.6880733944954, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI6677723, Length=215, Percent_Identity=26.9767441860465, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786676, Length=289, Percent_Identity=40.4844290657439, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324039, Length=231, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=317, Percent_Identity=23.0283911671924, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859927, Length=317, Percent_Identity=22.0820189274448, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921076, Length=215, Percent_Identity=26.5116279069767, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 68835; Mature: 68704

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESTLYRKYRPHKFKNVIGQDLIKQALMNACLNNKITHAYIFSGPRGIGKTSIARIFAS
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
SINCLNPNKGDCCGKCSVCESILKEQSVDLIELDAASNNGVDQIRIITDNINYLPTFFKY
HCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHEE
KVYIIDEAHMLSTSANALLKTVEEPPQHVIFIFATTEYQKIPLTIISRCQRYDFKRLNNS
EEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHH
ELQELIDSILTKEDIKIDNNAIDKLIQLADGSGRDCLSILDQLTTVKKNIDLDLINKTFG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHH
LVDNFKVISLIELIQKNDILLLREFIYELYNQGVNLEAFCVQIINVLIDYLIYLKTNDIN
HHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCC
NLKKVSVDELKKMLLINFNGNYLLNNFISLFNNLKKSLNQVFEFEIYLYKIINANNDKLE
CHHCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCC
NKKIELSINPEENKINNSQIITTKKIDCFEEINKNTVDFDKLYKTKIFYHKKINNQNDKE
CCEEEEEECCCCCCCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCHH
SGINQKEELSTELVNDNKLICNSNDILDNYELAKQAFFNKDIKLSKEMSQKFKDFKNEET
HCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
IENSYIDIIKQADLVLWCSPNALVLGVEFLGLINRINKVTHSFEFIKEFVKKFDSIKLVI
HHHHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AISKKQALNIINIKKQGLKTNIINDVLIDDIKMLLKQEEQRKQEQTALLNEIEDEE
EECCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SESTLYRKYRPHKFKNVIGQDLIKQALMNACLNNKITHAYIFSGPRGIGKTSIARIFAS
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
SINCLNPNKGDCCGKCSVCESILKEQSVDLIELDAASNNGVDQIRIITDNINYLPTFFKY
HCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHEE
KVYIIDEAHMLSTSANALLKTVEEPPQHVIFIFATTEYQKIPLTIISRCQRYDFKRLNNS
EEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHH
ELQELIDSILTKEDIKIDNNAIDKLIQLADGSGRDCLSILDQLTTVKKNIDLDLINKTFG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHH
LVDNFKVISLIELIQKNDILLLREFIYELYNQGVNLEAFCVQIINVLIDYLIYLKTNDIN
HHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCC
NLKKVSVDELKKMLLINFNGNYLLNNFISLFNNLKKSLNQVFEFEIYLYKIINANNDKLE
CHHCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCC
NKKIELSINPEENKINNSQIITTKKIDCFEEINKNTVDFDKLYKTKIFYHKKINNQNDKE
CCEEEEEECCCCCCCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHEEECCCCCCCCHH
SGINQKEELSTELVNDNKLICNSNDILDNYELAKQAFFNKDIKLSKEMSQKFKDFKNEET
HCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
IENSYIDIIKQADLVLWCSPNALVLGVEFLGLINRINKVTHSFEFIKEFVKKFDSIKLVI
HHHHHHHHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AISKKQALNIINIKKQGLKTNIINDVLIDDIKMLLKQEEQRKQEQTALLNEIEDEE
EECCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]