Click here to switch to the map view.

The map label for this gene is dnaA

Identifier: 170762315

GI number: 170762315

Start: 27

End: 1400

Strand: Direct

Name: dnaA

Synonym: UPA3_0001

Alternate gene names: 170762315

Gene position: 27-1400 (Clockwise)

Preceding gene: NA

Following gene: 170762277

Centisome position: 0.0

GC content: 24.67

Gene sequence:

>1374_bases
ATGGCTAATAATTATCAAACTTTATATGATTCAGCAATAAAAAGGATTCCATACGATCTTATTTCTGATCAAGCTTATGC
AATTCTACAAAATGCTAAAACTCATAAAGTTTGCGATGGTGTTTTATATATAATTGTAGCCAATGCCTTTGAAAAAAGTA
TTATTAACGGTAATTTTATTAACATTATTTCTAAATATCTAAGCGAAGAATTCAAAAAGGAAAATATTGTTAATTTTGAA
TTTATTATAGACAATGAAAAATTATTAATTAATAGCAATTTTTTAATTAAAGAAACTAATATTAAAAATCGTTTTAATTT
TAGTGATGAACTTTTACGTTACAATTTTAACAATTTAGTAATTAGTAATTTTAATCAAAAAGCGATTAAGGCGATTGAAA
ATTTATTTTCAAATAACTATGATAATAGTTCAATGTGTAACCCTTTATTTTTATTTGGTAAAGTTGGTGTTGGTAAAACG
CATATCGTGGCTGCTGCTGGTAATCGTTTTGCTAATAGTAATCCTAATTTAAAAATTTATTATTATGAAGGGCAAGATTT
TTTTCGAAAGTTTTGTTCTGCTTCGTTAAAAGGGACTAGTTATGTTGAAGAGTTTAAAAAAGAAATTGCTTCAGCAGATT
TATTAATTTTTGAAGATATTCAAAATATCCAATCACGTGATTCAACGGCTGAATTGTTTTTTAATATCTTTAATGATATA
AAATTAAATGGTGGAAAAATTATCTTAACATCTGACCGTACACCAAACGAACTTAATGGTTTTCATAATCGAATTATTTC
GAGATTAGCGTCAGGTTTGCAGTGTAAAATTTCTCAACCCGACAAAAATGAAGCTATTAAAATTATTAATAATTGGTTTG
AATTCAAAAAAAAATATCAAATTACTGACGAAGCTAAAGAATATATTGCTGAAGGTTTTCACACTGATATTAGACAGATG
ATTGGTAATCTAAAACAAATTTGTTTTTGAGCGGACAATGATACTAATAAAGATTTAATAATCACAAAAGATTATGTAAT
TGAGTGTTCAGTTGAAAACGAAATTCCACTAAATATTGTTGTTAAAAAACAATTTAAACCTGAACAAATAATTGAAATTG
TTGCAAAAGAATTAAATATAAAAACAGATTTAATTAAATCTTCTATTAGAAAAAATAATATAGTTTGAGCGCGTGATATT
GTTTGTTATATTCTAAAAAATAAACTAAATTTAACTTTAACAGATATTGGTAAATTACTAAACGGACGAGAACACACTAC
AATTAGTCATAGTATTAGTAAAGTTCAAAAAATTCTTGATGATGAAAATAGTCAAGAAGCACTACAAATTAATCTAATTA
TCAATAAATTTTAA

Upstream 100 bases:

>100_bases
TAATATATTTTTTTAAAAAAGTCAATGATATCTTTTTAAAAATAAACATATATAATATGATAATAGGACAAAGATTATTT
ATAAAAAATAGAGGTTACTA

Downstream 100 bases:

>100_bases
TTTTATTAAAGAAAAGTAATCAAAACTTATTAAAATATTATATATTTATATATAGTGTATTTTCGTGTTTTTGAACTCAA
AACATAAAATTACTAATTTT

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFINIISKYLSEEFKKENIVNFE
FIIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLVISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKT
HIVAAAGNRFANSNPNLKIYYYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDI
KLNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQITDEAKEYIAEGFHTDIRQM
IGNLKQICFWADNDTNKDLIITKDYVIECSVENEIPLNIVVKKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIVWARDI
VCYILKNKLNLTLTDIGKLLNGREHTTISHSISKVQKILDDENSQEALQINLIINKF

Sequences:

>Translated_457_residues
MANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFINIISKYLSEEFKKENIVNFE
FIIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLVISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKT
HIVAAAGNRFANSNPNLKIYYYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDI
KLNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQITDEAKEYIAEGFHTDIRQM
IGNLKQICF*ADNDTNKDLIITKDYVIECSVENEIPLNIVVKKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIV*ARDI
VCYILKNKLNLTLTDIGKLLNGREHTTISHSISKVQKILDDENSQEALQINLIINKF
>Mature_456_residues
ANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFINIISKYLSEEFKKENIVNFEF
IIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLVISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKTH
IVAAAGNRFANSNPNLKIYYYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDIK
LNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQITDEAKEYIAEGFHTDIRQMI
GNLKQICF*ADNDTNKDLIITKDYVIECSVENEIPLNIVVKKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIV*ARDIV
CYILKNKLNLTLTDIGKLLNGREHTTISHSISKVQKILDDENSQEALQINLIINKF

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=335, Percent_Identity=29.8507462686567, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52247; Mature: 52116

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFI
CCCCHHHHHHHHHHHCCHHHHCCHHHHHHHCCCHHHHHHHHHEEEEHHHHHHHHCCCHHH
NIISKYLSEEFKKENIVNFEFIIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLV
HHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEE
ISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKTHIVAAAGNRFANSNPNLKIY
EECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEE
YYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDI
EECCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCHHHHHHHHHHHHE
KLNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQ
EECCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
ITDEAKEYIAEGFHTDIRQMIGNLKQICFADNDTNKDLIITKDYVIECSVENEIPLNIVV
CCHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEECEEEEEEECCCCCEEEEE
KKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIVARDIVCYILKNKLNLTLTDIGKLLNG
ECCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHCC
REHTTISHSISKVQKILDDENSQEALQINLIINKF
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
ANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFI
CCCHHHHHHHHHHHCCHHHHCCHHHHHHHCCCHHHHHHHHHEEEEHHHHHHHHCCCHHH
NIISKYLSEEFKKENIVNFEFIIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLV
HHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEE
ISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKTHIVAAAGNRFANSNPNLKIY
EECCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEE
YYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDI
EECCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCHHHHHHHHHHHHE
KLNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQ
EECCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
ITDEAKEYIAEGFHTDIRQMIGNLKQICFADNDTNKDLIITKDYVIECSVENEIPLNIVV
CCHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCEEEEECEEEEEEECCCCCEEEEE
KKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIVARDIVCYILKNKLNLTLTDIGKLLNG
ECCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHCC
REHTTISHSISKVQKILDDENSQEALQINLIINKF
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA