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The map label for this gene is hmuU [H]

Identifier: 170762245

GI number: 170762245

Start: 85380

End: 86450

Strand: Reverse

Name: hmuU [H]

Synonym: UPA3_0069

Alternate gene names: 170762245

Gene position: 86450-85380 (Counterclockwise)

Preceding gene: 170762032

Following gene: 170762176

Centisome position: 11.5

GC content: 26.52

Gene sequence:

>1071_bases
ATGAAAATTAATCAAAAAACGAATTTAAAGCAAAAGCATTTTTATTTAATTAAAAATCTTAATTATAAACAATCTGTAAT
CATTAAAATGGCAGGACTAATTCTCATTGCCATTTGTTTTGTTTTTTTAACATTAGCAATTTATTTTGATACCACTAATG
GTTTTGAAGCATCGATCAATCAATTTAATTTTAATATTCGTGGTCCTAAAACTTTAATGGCCTTTTTTTCAGGAGGAGCA
ATTGCTGTAGCTGGATTATTATTACAAAAAGTTACACGTAATCATTTAGCAGATACGTCAGTTTTAGGTATTGGTTCATT
AAACATCATTTTAATGACAGTATATTTAATTCTTATTAAAGATAAAACAAGCAGTTATTTAAATCCTGAAATGCGAATTT
TACCCTTGGTGATGTTTTTATCATCAATTTTTGGAACAAGTATTGTTTATACATTATCAAAATTAGGAAGAGCTAATAAT
GAAAAATTTATTATTATCGGAATTGCTTTGAATTTTTTATTTGAAGCGATTTCCGTGGTTTTAATTAATCCTGCTAATAA
TTCATTGTTCTCCAATCAAGATAAAAATTTAATGATTGCTTTTGAAAATATCAAAAATTATACTTTAGGAATTATTCCAA
ATTCGCAATATATTGATTTATCATTAGTAATCTCTTGCTCAGTATTAATTGCATTAACATTGATTCCAATTTGATTTTTA
CGTAAAAAAATTGATTTATACGAAACAAGCGCTGCTTTAGCATCAACAACAGGAATTAATATTGAGCGTTTAAAAATTAG
TATTTATTTACTAGTGGCTTTATTAGCAGGATTAGAAATTGTTTTAGTTGGTTATATAGCTTTATTAGGAGTTATTGGCG
CTAGCGTTGCACGTCAATTATTTGGTAATAGAACAGGTATTACAATGTTTGCAGCATTTTTAATCGGCGCAACTTTAGTG
TGTTTTGCGTTATTAATTTCGGTTAATTTTAATACACAAGTACCAGTTGGTTTTTTATCAACAACAATTATTACACCTTA
TTTTATGTATCTAATTGTGAGAGGAAAATAA

Upstream 100 bases:

>100_bases
ATTAATCCAACAAAATAAACAATTGTTAAAAGAAGCTAATGATTGGGGTTCATATTGAAAAACATTTGTTAACCAAAAAT
AATAAAAAAAACGAGAATCA

Downstream 100 bases:

>100_bases
AAATATGTTTAAAATTTTTGCTAAATACTTTTGCAATCATCAATTAGATCGGAATCAAATTATTAATGCAAGTAAAAACG
ACGCTTTAATTATTAATAAT

Product: hemin transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASINQFNFNIRGPKTLMAFFSGGA
IAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIKDKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANN
EKFIIIGIALNFLFEAISVVLINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPIWFL
RKKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLFGNRTGITMFAAFLIGATLV
CFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK

Sequences:

>Translated_356_residues
MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASINQFNFNIRGPKTLMAFFSGGA
IAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIKDKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANN
EKFIIIGIALNFLFEAISVVLINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPI*FL
RKKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLFGNRTGITMFAAFLIGATLV
CFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK
>Mature_356_residues
MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASINQFNFNIRGPKTLMAFFSGGA
IAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIKDKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANN
EKFIIIGIALNFLFEAISVVLINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPI*FL
RKKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLFGNRTGITMFAAFLIGATLV
CFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=311, Percent_Identity=25.4019292604502, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786347, Length=356, Percent_Identity=22.752808988764, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790741, Length=295, Percent_Identity=25.0847457627119, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 39079; Mature: 39079

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASIN
CCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
QFNFNIRGPKTLMAFFSGGAIAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIK
EEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHEE
DKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANNEKFIIIGIALNFLFEAISVV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHEE
LINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPIFLR
EECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHH
KKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLF
HHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNRTGITMFAAFLIGATLVCFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASIN
CCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
QFNFNIRGPKTLMAFFSGGAIAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIK
EEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHEE
DKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANNEKFIIIGIALNFLFEAISVV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHEE
LINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPIFLR
EECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHH
KKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLF
HHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNRTGITMFAAFLIGATLVCFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]