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The map label for this gene is pth

Identifier: 170762127

GI number: 170762127

Start: 94834

End: 95394

Strand: Reverse

Name: pth

Synonym: UPA3_0077

Alternate gene names: 170762127

Gene position: 95394-94834 (Counterclockwise)

Preceding gene: 170762142

Following gene: 170761927

Centisome position: 12.69

GC content: 25.85

Gene sequence:

>561_bases
GTGGAAAAATATTTAATTGTTGGATTAGGTAATCCAGGATCAAACTATGCAAAAACAAGACATAATGTTGGCTTTATGGT
TATTAATGAGATTTGCAACAAACTTAATTTGTCTCTAGATAGTTCAAAATTTAATGGAATTTTTACTAAAACAATTTATA
ACAATTCCATAGTGTTTTTTTGTCAACCAACAACTTACATGAATTTAAGTGGTGAATTTGTTATCAAAATGCTTAATTTT
TATAATATTCCAATTAAAAATTTAATAGTTATTTATGATGATGTTGATACGAAATTAGGAACGATAAAATTGAGAAAAAA
GGGGTCCTCAGGAGGGCAAAATGGAATTAAAAATATTATTAACATTTTAAAAACAGATGAAATTAAACGCATTCGTATAG
GAATTGATAAAGATCCACATATAAAATTAGATCAATATGTCTTATCGAATTTTAAGATTGACGAATTAGTTATAATTAAA
CCAGCTATTATAAAGGGCGCTTTAGCTACATTAGCAGCGATTGGTGAAGATTTTGATAAAGTTATGAACAAATTTAATTA
A

Upstream 100 bases:

>100_bases
TTAAGTGTTTAAATGTGCATAACTTAAAATTCATCTATTATATAATAATTTTATTGAAGAGATTTATAAACATTGTACGT
TTATAATATGGGTATTAAAT

Downstream 100 bases:

>100_bases
TAGAATTAGTAATAAAAAATACTTAGCTGCTGTTTCTGGTGGTCCAGATTCTATGGCAATGTTAAATATGTACAAAAGAA
ATATTCGTGTTGTTTGTCAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFFCQPTTYMNLSGEFVIKMLNF
YNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNIINILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIK
PAIIKGALATLAAIGEDFDKVMNKFN

Sequences:

>Translated_186_residues
MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFFCQPTTYMNLSGEFVIKMLNF
YNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNIINILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIK
PAIIKGALATLAAIGEDFDKVMNKFN
>Mature_186_residues
MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFFCQPTTYMNLSGEFVIKMLNF
YNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNIINILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIK
PAIIKGALATLAAIGEDFDKVMNKFN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=158, Percent_Identity=25.3164556962025, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=34.5744680851064, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_UREP2 (B1AI63)

Other databases:

- EMBL:   CP000942
- RefSeq:   YP_001752157.1
- ProteinModelPortal:   B1AI63
- SMR:   B1AI63
- GeneID:   6155417
- GenomeReviews:   CP000942_GR
- KEGG:   upa:UPA3_0077
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   UPAR505682:UPA3_0077-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20940; Mature: 20940

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFF
CCCEEEEEECCCCCCCHHHHCCCCCEEHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEE
CQPTTYMNLSGEFVIKMLNFYNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNII
ECCCEEEECCHHHHHEEHHHCCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
NILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIKPAIIKGALATLAAIGEDFDK
HHHCCCCEEEEEEECCCCCCEEHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VMNKFN
HHHHCC
>Mature Secondary Structure
MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFF
CCCEEEEEECCCCCCCHHHHCCCCCEEHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEE
CQPTTYMNLSGEFVIKMLNFYNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNII
ECCCEEEECCHHHHHEEHHHCCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
NILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIKPAIIKGALATLAAIGEDFDK
HHHCCCCEEEEEEECCCCCCEEHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VMNKFN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA