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The map label for this gene is tpiA

Identifier: 170761975

GI number: 170761975

Start: 218563

End: 219279

Strand: Direct

Name: tpiA

Synonym: UPA3_0188

Alternate gene names: 170761975

Gene position: 218563-219279 (Clockwise)

Preceding gene: 170762102

Following gene: 170762100

Centisome position: 29.08

GC content: 22.45

Gene sequence:

>717_bases
ATGAAATATATTATTGCTAATTTTAAAATGAATGCAACACAAGAATTAATTAATCATTTTTTAAATAATTTAACGTTATT
TGATGAGCAAAAAATTATTATTGGTTTAGCACCAGGGGATTTATATTTAAAAACATTTGTTAATTTAGCTGAAATAAAAA
AAGTCAATTTATATGCTCAAAACCCATCATTACATAATAAAGGACCTTATACAGGTCAAATAAGTTGTTTACAATTATTA
GATATTAATATTAAAAATGCTTTAGTTGGGCATAGTGAAATACGTATTGATTTTTCACAATCAATAATTGATCAAAAAAT
AAAAATATCTATGGATTTATTAGAACAAGTCATCATTTGTGTTGGCGAAACTTTTGATGCTTATAAACAAAATAAATCAC
TTAATTTTGTTTTAAATCAATTAGCCAACATCATTAATTACAAAGGATTAAAAAAAATTATTATCGCTTATGAACCAATT
TGAGCAATTGGCACTGATTTAGAATTAGATTTTAAACATATTAATTACATGATCGAAGGAATTAAAACATATTTATATAA
TTGTACTGGAATAAATATTCCTATTTTATATGGCGGTAGTGTTAATGACAATAATATTAATGAATTGTGCAATCAAAAAT
TAATCGATGGTTTTTTAATTGGCAATGCTTCATTAGATGTTAATGTTTTTAATAAAATTATCGATAAATGTAAATAA

Upstream 100 bases:

>100_bases
TGTTTTAATTTCCCTACACTTATAATTTTTATCATCATCTTAGTTAAATAACCTTTTTTTTGATTATAATCTAACTAAGA
TTATAAAGGATAATGATTCA

Downstream 100 bases:

>100_bases
TAAAATGGATTAGAATATGAAATTAAATAAAAAAATAGGTTTGATAATCATTGATGGATTAGGAATTGGAAAAGAAGATA
ATACTAATGCTGTTCATTTA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQNPSLHNKGPYTGQISCLQLL
DINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIICVGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPI
WAIGTDLELDFKHINYMIEGIKTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK

Sequences:

>Translated_238_residues
MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQNPSLHNKGPYTGQISCLQLL
DINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIICVGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPI
*AIGTDLELDFKHINYMIEGIKTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK
>Mature_238_residues
MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQNPSLHNKGPYTGQISCLQLL
DINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIICVGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPI
*AIGTDLELDFKHINYMIEGIKTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=233, Percent_Identity=29.6137339055794, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI226529917, Length=233, Percent_Identity=29.6137339055794, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790353, Length=246, Percent_Identity=28.8617886178862, Blast_Score=101, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17536593, Length=244, Percent_Identity=31.9672131147541, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320255, Length=231, Percent_Identity=32.034632034632, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28572008, Length=229, Percent_Identity=32.3144104803493, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28572006, Length=229, Percent_Identity=32.3144104803493, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28572004, Length=230, Percent_Identity=32.1739130434783, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26775; Mature: 26775

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQ
CCEEEEECCCCCHHHHHHHHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHEEEEEEC
NPSLHNKGPYTGQISCLQLLDINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIIC
CCCCCCCCCCCCCEEEEEEEECCHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPIAIGTDLELDFKHINYMIEGI
HCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCEEHHHHHHHHHHHH
KTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK
HHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHCEEEECCCEECHHHHHHHHHHCC
>Mature Secondary Structure
MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQ
CCEEEEECCCCCHHHHHHHHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHEEEEEEC
NPSLHNKGPYTGQISCLQLLDINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIIC
CCCCCCCCCCCCCEEEEEEEECCHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
VGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPIAIGTDLELDFKHINYMIEGI
HCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCEEHHHHHHHHHHHH
KTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK
HHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHCEEEECCCEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA