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The map label for this gene is copA [H]

Identifier: 170761926

GI number: 170761926

Start: 246928

End: 249057

Strand: Direct

Name: copA [H]

Synonym: UPA3_0209

Alternate gene names: 170761926

Gene position: 246928-249057 (Clockwise)

Preceding gene: 170762313

Following gene: 170761895

Centisome position: 32.85

GC content: 25.07

Gene sequence:

>2130_bases
ATGTTAAAGAATAATTTAATTAAAAAATTTCAATTACTACCTATTAATAAAAGAAGATATTTAATTTCTTTAATGAAAAC
ATCAATAGCACTTCTAATTAGTATTCCTTTAATGGTTTTTGAAATGCTATTTATGTTTAAAAGTAATTTAATTTTAAGCA
TTGATGGTTATTTTATATATGGATGAATTGTTTTTGTTTTAAGTATTTTCATTGTCTTTGGTTTAGGTTTTAGTTTTTTT
AAGGGTGCTTTTTTTGAAGTTTTTAAATGAAAAAAACCTGGAATGTCTTTACTTGTTGTTATTTCAACATGTGTTGCTTT
CATATATAGTACTTATAGTTTAATTTCTAACACAATTATTTATGAACCTAAACTACATGGTTTTTTTGAAACAGCTTGCA
TGATTATAGCGACAATGAGTGTTGGTCAATTAGTTAGTGATCGTATTAAACTAAAAGCAAATCAAGATCTACAATCTTTA
AATAATTTACAAGTCAAAAAATATAATAGTTATGATTTGAACACAAAACAAGTTAGTGAAAAAGTTGTTTTTCAAGCTAA
AATTAACGAATACGCACTAGTTAAAAAAGGTGAAATTGTTCCATTAGATGGCGTATTATATTCACAAATTGCTGAAGTTG
ATGAATCATCATTAACTGGTGAAGCTCGTCCAATTCTAAAAACAATTAATAATGATATTATTGCTGGATCAATTAATGTT
GGAGATAATTTTATTTTTAAAATTACTAAACTTTATAATGATTCAACGATTAAAAAAATTATTAATGGTGTTAATCAAAT
TGCTAGTAGCAAGCCAAAAATTCAAGTTGTTGCTGATAAGATTTCGTTATGATTCACTCCATTTATCTTATTAATGGCCA
TTCTAGCTTTTTTACTACAAGCTTTTGTACCAAGTATTCAAGAGTTACCAATTGCTTTTTTAAATCTTCATGGATCAAAT
AATGATTCTAATTTATATGAAAAAGCAGCATATGTAGCAGTTTCTGTTCTAGTTATATCATGTCCATGTGCATTTGGTAT
TGCTGTGCCTTTAGCAGTTTTAATTGGTGCAGGGCATGGTGCTAAAAGTGGGATTACATTTAACAATAGTAATATTTTTG
AAAAGATTAAAAAAGTTAATGCAATTGCTTTTGATAAAACAGGGACATTAACTTATGGAAAATTACAATTAAAACAAGTT
ATAGGAAATGATCAATTTTTAGATTTAATTTATCAAATGGAATTAATTTCTTTACATCCACTAGCAAAATCATTCGTAAC
TTATGCCATTATTAATAATATCGTCATGAGTACAAAATTAATTGATATTAAAGAAGTTGCAGGAGTGGGGATTATTGCTA
AAGATGTTGATGGTAATATTTATGAATTAACATCAGAACATTATGCAAATGAAAATCAATTTGATTTTTCATTGATTAAT
CAAAAATCTTCTACTTCTACTAATTTATTAGCTTCAAATATTATTTTTAGTATTAACAAAAAGGTGCAATCAATTCTTGT
TTTTGAAGATGAAATTCGTGCTGATGCTTATGAAACAATTAAGGTATTGCATGAAAATAATATTGAAACTTATATGATTA
CTGGTGATAGTTTTAATGTTGCTCAAAAAATCGCAAAGGAATTAGGAATTAAACATTTTTATGCTCAAGTTAAACCAGAA
GAAAAAGCTAACATTATTAAAAAAATTCAAAATGATCAAAAAACTGTAATGTATGTTGGCGATGGTATTAATGATTTATT
AGCTTTAAAACAAGCTAATGTTTCTATATCAATTGGTGAAACTAATAAAGCAACTAATGCAGTTGCTGATATTAGTTTAA
TCAAACCAGATATTTTAAATATTTACAAAGTAATTAAACTAACAAAAATTACTAAGATGTTTATTGTAAGTAGTTTACTA
TGAGCGTTTGGTTATAATCTAATTTTTATTCCACTAGCATTAATTGGTATTATTCCACCATTTATTTCTGTTTTAATTAT
GACAACTAGTGATATTGCTGTTGTATTAAACTCATTAATTTTTAGATTATTAAAAATGCGTCTAGTTAATAAAAAGCAAA
TTCATAAACTTAATTTAAAAATTATCAATGAGGCTATGTTACATAAATAA

Upstream 100 bases:

>100_bases
TGAATTTGAAGAAAATAAAATTGCTGATCAAGATGTAATTAAAGAAATCAATAAAAATGGTTTCAAAACAAATATTTTAG
AAAAATACATATACTAAAAA

Downstream 100 bases:

>100_bases
TTTTATTTATTTTTTAATTTACTAATTAAATAAAAAAACACTTGTTGTATATTAAACAAGTGTTTTTGTTTTAATTAATT
AATAAACTCATGCGAAGATG

Product: copper-transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MLKNNLIKKFQLLPINKRRYLISLMKTSIALLISIPLMVFEMLFMFKSNLILSIDGYFIYGWIVFVLSIFIVFGLGFSFF
KGAFFEVFKWKKPGMSLLVVISTCVAFIYSTYSLISNTIIYEPKLHGFFETACMIIATMSVGQLVSDRIKLKANQDLQSL
NNLQVKKYNSYDLNTKQVSEKVVFQAKINEYALVKKGEIVPLDGVLYSQIAEVDESSLTGEARPILKTINNDIIAGSINV
GDNFIFKITKLYNDSTIKKIINGVNQIASSKPKIQVVADKISLWFTPFILLMAILAFLLQAFVPSIQELPIAFLNLHGSN
NDSNLYEKAAYVAVSVLVISCPCAFGIAVPLAVLIGAGHGAKSGITFNNSNIFEKIKKVNAIAFDKTGTLTYGKLQLKQV
IGNDQFLDLIYQMELISLHPLAKSFVTYAIINNIVMSTKLIDIKEVAGVGIIAKDVDGNIYELTSEHYANENQFDFSLIN
QKSSTSTNLLASNIIFSINKKVQSILVFEDEIRADAYETIKVLHENNIETYMITGDSFNVAQKIAKELGIKHFYAQVKPE
EKANIIKKIQNDQKTVMYVGDGINDLLALKQANVSISIGETNKATNAVADISLIKPDILNIYKVIKLTKITKMFIVSSLL
WAFGYNLIFIPLALIGIIPPFISVLIMTTSDIAVVLNSLIFRLLKMRLVNKKQIHKLNLKIINEAMLHK

Sequences:

>Translated_709_residues
MLKNNLIKKFQLLPINKRRYLISLMKTSIALLISIPLMVFEMLFMFKSNLILSIDGYFIYG*IVFVLSIFIVFGLGFSFF
KGAFFEVFK*KKPGMSLLVVISTCVAFIYSTYSLISNTIIYEPKLHGFFETACMIIATMSVGQLVSDRIKLKANQDLQSL
NNLQVKKYNSYDLNTKQVSEKVVFQAKINEYALVKKGEIVPLDGVLYSQIAEVDESSLTGEARPILKTINNDIIAGSINV
GDNFIFKITKLYNDSTIKKIINGVNQIASSKPKIQVVADKISL*FTPFILLMAILAFLLQAFVPSIQELPIAFLNLHGSN
NDSNLYEKAAYVAVSVLVISCPCAFGIAVPLAVLIGAGHGAKSGITFNNSNIFEKIKKVNAIAFDKTGTLTYGKLQLKQV
IGNDQFLDLIYQMELISLHPLAKSFVTYAIINNIVMSTKLIDIKEVAGVGIIAKDVDGNIYELTSEHYANENQFDFSLIN
QKSSTSTNLLASNIIFSINKKVQSILVFEDEIRADAYETIKVLHENNIETYMITGDSFNVAQKIAKELGIKHFYAQVKPE
EKANIIKKIQNDQKTVMYVGDGINDLLALKQANVSISIGETNKATNAVADISLIKPDILNIYKVIKLTKITKMFIVSSLL
*AFGYNLIFIPLALIGIIPPFISVLIMTTSDIAVVLNSLIFRLLKMRLVNKKQIHKLNLKIINEAMLHK
>Mature_709_residues
MLKNNLIKKFQLLPINKRRYLISLMKTSIALLISIPLMVFEMLFMFKSNLILSIDGYFIYG*IVFVLSIFIVFGLGFSFF
KGAFFEVFK*KKPGMSLLVVISTCVAFIYSTYSLISNTIIYEPKLHGFFETACMIIATMSVGQLVSDRIKLKANQDLQSL
NNLQVKKYNSYDLNTKQVSEKVVFQAKINEYALVKKGEIVPLDGVLYSQIAEVDESSLTGEARPILKTINNDIIAGSINV
GDNFIFKITKLYNDSTIKKIINGVNQIASSKPKIQVVADKISL*FTPFILLMAILAFLLQAFVPSIQELPIAFLNLHGSN
NDSNLYEKAAYVAVSVLVISCPCAFGIAVPLAVLIGAGHGAKSGITFNNSNIFEKIKKVNAIAFDKTGTLTYGKLQLKQV
IGNDQFLDLIYQMELISLHPLAKSFVTYAIINNIVMSTKLIDIKEVAGVGIIAKDVDGNIYELTSEHYANENQFDFSLIN
QKSSTSTNLLASNIIFSINKKVQSILVFEDEIRADAYETIKVLHENNIETYMITGDSFNVAQKIAKELGIKHFYAQVKPE
EKANIIKKIQNDQKTVMYVGDGINDLLALKQANVSISIGETNKATNAVADISLIKPDILNIYKVIKLTKITKMFIVSSLL
*AFGYNLIFIPLALIGIIPPFISVLIMTTSDIAVVLNSLIFRLLKMRLVNKKQIHKLNLKIINEAMLHK

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=672, Percent_Identity=27.9761904761905, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI55743071, Length=696, Percent_Identity=26.7241379310345, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI55743073, Length=641, Percent_Identity=25.1170046801872, Blast_Score=173, Evalue=4e-43,
Organism=Escherichia coli, GI1786691, Length=677, Percent_Identity=28.2127031019202, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1789879, Length=568, Percent_Identity=26.7605633802817, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1786914, Length=588, Percent_Identity=22.4489795918367, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17556548, Length=435, Percent_Identity=28.9655172413793, Blast_Score=154, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320475, Length=668, Percent_Identity=30.2395209580838, Blast_Score=267, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6319772, Length=703, Percent_Identity=28.3072546230441, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI221329854, Length=428, Percent_Identity=27.803738317757, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 78429; Mature: 78429

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNNLIKKFQLLPINKRRYLISLMKTSIALLISIPLMVFEMLFMFKSNLILSIDGYFIY
CCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHH
GIVFVLSIFIVFGLGFSFFKGAFFEVFKKKPGMSLLVVISTCVAFIYSTYSLISNTIIYE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEC
PKLHGFFETACMIIATMSVGQLVSDRIKLKANQDLQSLNNLQVKKYNSYDLNTKQVSEKV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHH
VFQAKINEYALVKKGEIVPLDGVLYSQIAEVDESSLTGEARPILKTINNDIIAGSINVGD
HEEEECCCEEEEECCCEEEECHHHHHHHHHHCHHCCCCCHHHHHHHCCCCEEEEEEECCC
NFIFKITKLYNDSTIKKIINGVNQIASSKPKIQVVADKISLFTPFILLMAILAFLLQAFV
CEEEEEEHHHCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
PSIQELPIAFLNLHGSNNDSNLYEKAAYVAVSVLVISCPCAFGIAVPLAVLIGAGHGAKS
CCHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
GITFNNSNIFEKIKKVNAIAFDKTGTLTYGKLQLKQVIGNDQFLDLIYQMELISLHPLAK
CEEECCCHHHHHHHHHHHEEECCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFVTYAIINNIVMSTKLIDIKEVAGVGIIAKDVDGNIYELTSEHYANENQFDFSLINQKS
HHHHHHHHHHHHHHHEEEEHHHHCCCCEEEECCCCCEEEECHHHCCCCCCCCHHEECCCC
STSTNLLASNIIFSINKKVQSILVFEDEIRADAYETIKVLHENNIETYMITGDSFNVAQK
CCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
IAKELGIKHFYAQVKPEEKANIIKKIQNDQKTVMYVGDGINDLLALKQANVSISIGETNK
HHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECCCCC
ATNAVADISLIKPDILNIYKVIKLTKITKMFIVSSLLAFGYNLIFIPLALIGIIPPFISV
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LIMTTSDIAVVLNSLIFRLLKMRLVNKKQIHKLNLKIINEAMLHK
HHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKNNLIKKFQLLPINKRRYLISLMKTSIALLISIPLMVFEMLFMFKSNLILSIDGYFIY
CCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHH
GIVFVLSIFIVFGLGFSFFKGAFFEVFKKKPGMSLLVVISTCVAFIYSTYSLISNTIIYE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEC
PKLHGFFETACMIIATMSVGQLVSDRIKLKANQDLQSLNNLQVKKYNSYDLNTKQVSEKV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHH
VFQAKINEYALVKKGEIVPLDGVLYSQIAEVDESSLTGEARPILKTINNDIIAGSINVGD
HEEEECCCEEEEECCCEEEECHHHHHHHHHHCHHCCCCCHHHHHHHCCCCEEEEEEECCC
NFIFKITKLYNDSTIKKIINGVNQIASSKPKIQVVADKISLFTPFILLMAILAFLLQAFV
CEEEEEEHHHCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
PSIQELPIAFLNLHGSNNDSNLYEKAAYVAVSVLVISCPCAFGIAVPLAVLIGAGHGAKS
CCHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
GITFNNSNIFEKIKKVNAIAFDKTGTLTYGKLQLKQVIGNDQFLDLIYQMELISLHPLAK
CEEECCCHHHHHHHHHHHEEECCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFVTYAIINNIVMSTKLIDIKEVAGVGIIAKDVDGNIYELTSEHYANENQFDFSLINQKS
HHHHHHHHHHHHHHHEEEEHHHHCCCCEEEECCCCCEEEECHHHCCCCCCCCHHEECCCC
STSTNLLASNIIFSINKKVQSILVFEDEIRADAYETIKVLHENNIETYMITGDSFNVAQK
CCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
IAKELGIKHFYAQVKPEEKANIIKKIQNDQKTVMYVGDGINDLLALKQANVSISIGETNK
HHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECCCCC
ATNAVADISLIKPDILNIYKVIKLTKITKMFIVSSLLAFGYNLIFIPLALIGIIPPFISV
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LIMTTSDIAVVLNSLIFRLLKMRLVNKKQIHKLNLKIINEAMLHK
HHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA