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The map label for this gene is ykcC [H]

Identifier: 170757610

GI number: 170757610

Start: 377526

End: 378494

Strand: Direct

Name: ykcC [H]

Synonym: CLD_0453

Alternate gene names: 170757610

Gene position: 377526-378494 (Clockwise)

Preceding gene: 170757281

Following gene: 170754483

Centisome position: 9.54

GC content: 29.62

Gene sequence:

>969_bases
GTGATTAATAAAATAGTTTATTCCATAATAGTTCCTTTATATAATGAAGAACTTGTTATTGATGAAAGTTATAGAAGATT
AAAGGCAGTTATGGATTCTACAAAAGAAAATTATGAAATTATATTTATAAATGATGGAAGTAGAGATTCAACTAAAGAAA
AAGCAGATAATATATGTAAAAAGGATGAAAAAATAAAACTTGTAAATTTCTCTAGGAACTTTGGACATCAAGCTGCTATA
ACTGCGGGAATGGATGTATCTAGAGGTAGGGCTATTGTGGTAATTGATGCGGATCTTCAGGACCCACCAGAGGTTATTCT
TAAAATGATTGAAAAATGGAAAGATGGGTACGAAGTAGTATATGGAAAAAGGGCTAAAAGAGAAGGTGAAGGATTTTTCA
AAAAATTTACTGCGGGAGTGTTTTATAGATTGTTAAAGAACATAACAAATATAGATATTCCAGTGGATACAGGAGATTTT
AGGCTTATAGATAGAAAGGTATGTGATACTTTAACATCACTTCCAGAAAAAAATAGATACGTAAGAGGATTGGTAAGTTG
GGTTGGGTATAAACAAACTGCAGTAGAATTCGTAAGACAAGAAAGGTTTGCTGGAGAGACTAAATATCCATTAAAGAAGA
TGCTTAAATTAGCCTTTGATGGAATAACATCCTTTTCATATAAACCACTTACAGTCGCTAGCTATGTTGGAGGGACAATA
TTTTCTATAGGTACTATTGTATTTATAACTGAAATTATAAAGGCAGTAATAAACTGTACAGATATATTAAGTTTAGGAAT
GATATTATCAATTAATTTAATTATGTTTGGATTGATATTTTTTACCATTGGCATAATGGGCCAATATATTGGAAGAATTT
TCGATGAAAGTAAGAATAGGCCCATGTATATAATCGATAATACTATAAATTATAAGAAGGTTGATAAAAAATATGAAATT
AATGACTAA

Upstream 100 bases:

>100_bases
TTTTAAATAAGGAAAGTTTAAAGGCAGCTTAATTTTAATAAATGACTTAAAAAATCAGTTTAAAGACATAATCAAATAAC
AATTTCATGAGGTGATAAAA

Downstream 100 bases:

>100_bases
AGTAAACAAATATATATTCCATGGCAAATTTAAACATATAAGTCGTTTTTCAATAGTAGGTGTTGCAAATACTGGCATAG
ACTTTTTAATGTTTACAATA

Product: glycosyl transferase, group 2 family protein

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MINKIVYSIIVPLYNEELVIDESYRRLKAVMDSTKENYEIIFINDGSRDSTKEKADNICKKDEKIKLVNFSRNFGHQAAI
TAGMDVSRGRAIVVIDADLQDPPEVILKMIEKWKDGYEVVYGKRAKREGEGFFKKFTAGVFYRLLKNITNIDIPVDTGDF
RLIDRKVCDTLTSLPEKNRYVRGLVSWVGYKQTAVEFVRQERFAGETKYPLKKMLKLAFDGITSFSYKPLTVASYVGGTI
FSIGTIVFITEIIKAVINCTDILSLGMILSINLIMFGLIFFTIGIMGQYIGRIFDESKNRPMYIIDNTINYKKVDKKYEI
ND

Sequences:

>Translated_322_residues
MINKIVYSIIVPLYNEELVIDESYRRLKAVMDSTKENYEIIFINDGSRDSTKEKADNICKKDEKIKLVNFSRNFGHQAAI
TAGMDVSRGRAIVVIDADLQDPPEVILKMIEKWKDGYEVVYGKRAKREGEGFFKKFTAGVFYRLLKNITNIDIPVDTGDF
RLIDRKVCDTLTSLPEKNRYVRGLVSWVGYKQTAVEFVRQERFAGETKYPLKKMLKLAFDGITSFSYKPLTVASYVGGTI
FSIGTIVFITEIIKAVINCTDILSLGMILSINLIMFGLIFFTIGIMGQYIGRIFDESKNRPMYIIDNTINYKKVDKKYEI
ND
>Mature_322_residues
MINKIVYSIIVPLYNEELVIDESYRRLKAVMDSTKENYEIIFINDGSRDSTKEKADNICKKDEKIKLVNFSRNFGHQAAI
TAGMDVSRGRAIVVIDADLQDPPEVILKMIEKWKDGYEVVYGKRAKREGEGFFKKFTAGVFYRLLKNITNIDIPVDTGDF
RLIDRKVCDTLTSLPEKNRYVRGLVSWVGYKQTAVEFVRQERFAGETKYPLKKMLKLAFDGITSFSYKPLTVASYVGGTI
FSIGTIVFITEIIKAVINCTDILSLGMILSINLIMFGLIFFTIGIMGQYIGRIFDESKNRPMYIIDNTINYKKVDKKYEI
ND

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: COG0463

COG function: function code M; Glycosyltransferases involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=172, Percent_Identity=30.8139534883721, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788692, Length=298, Percent_Identity=40.2684563758389, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788588, Length=311, Percent_Identity=27.9742765273312, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325441, Length=112, Percent_Identity=33.9285714285714, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 36880; Mature: 36880

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKIVYSIIVPLYNEELVIDESYRRLKAVMDSTKENYEIIFINDGSRDSTKEKADNICK
CCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHC
KDEKIKLVNFSRNFGHQAAITAGMDVSRGRAIVVIDADLQDPPEVILKMIEKWKDGYEVV
CCCCEEEEEECCCCCCCHHEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
YGKRAKREGEGFFKKFTAGVFYRLLKNITNIDIPVDTGDFRLIDRKVCDTLTSLPEKNRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
VRGLVSWVGYKQTAVEFVRQERFAGETKYPLKKMLKLAFDGITSFSYKPLTVASYVGGTI
HHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHH
FSIGTIVFITEIIKAVINCTDILSLGMILSINLIMFGLIFFTIGIMGQYIGRIFDESKNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PMYIIDNTINYKKVDKKYEIND
CEEEEECCCCHHHCCCCCCCCC
>Mature Secondary Structure
MINKIVYSIIVPLYNEELVIDESYRRLKAVMDSTKENYEIIFINDGSRDSTKEKADNICK
CCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHC
KDEKIKLVNFSRNFGHQAAITAGMDVSRGRAIVVIDADLQDPPEVILKMIEKWKDGYEVV
CCCCEEEEEECCCCCCCHHEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
YGKRAKREGEGFFKKFTAGVFYRLLKNITNIDIPVDTGDFRLIDRKVCDTLTSLPEKNRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
VRGLVSWVGYKQTAVEFVRQERFAGETKYPLKKMLKLAFDGITSFSYKPLTVASYVGGTI
HHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHH
FSIGTIVFITEIIKAVINCTDILSLGMILSINLIMFGLIFFTIGIMGQYIGRIFDESKNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PMYIIDNTINYKKVDKKYEIND
CEEEEECCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]