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The map label for this gene is guaA

Identifier: 170756813

GI number: 170756813

Start: 3564691

End: 3566223

Strand: Reverse

Name: guaA

Synonym: CLD_1228

Alternate gene names: 170756813

Gene position: 3566223-3564691 (Counterclockwise)

Preceding gene: 170757052

Following gene: 170755722

Centisome position: 90.1

GC content: 31.9

Gene sequence:

>1533_bases
ATGAATAAAGAATTAGTATTAGTAGTTGACTTTGGAGGTCAATATAATCAGTTAATAGCAAGACGTGTAAGGGAAAATAG
AGTGTATTGTGAAATAGTACCTTATACTACTTCTATAGAAGATATAAAAGAAAAAGCACCAAAGGGAATAATATTTACAG
GTGGTCCTAATAGTGTATATGGAGAAAATGCACCAAGAGTTCAAAAAGAATTATTTGATTTAGGTATTCCAGTCTTAGGT
ATATGTTATGGAGATCAACTTATGGCACATAGCTTAGAAGGTGAAGTAACAAGTCCTGAAAAAAGAGAATATGGTAAAAC
AGATGTAAATTTAGATAATAGTAGTCTATTGTTTAAGGATATGAAAGAGAAAGATCAATGCTGGATGAGTCATACAGATT
ATATTTCAAAGGTTCCAAAGGGATTTAAAATTATAGCAACAACAGATGAGTGCCCTTGTGCAGCTATGGAAAATGCGGAA
AAAAAATTATATGGAGTTCAATTTCATCCAGAGGTAGAGCATACTTTATTTGGGAAAAAAATGCTTAAGAACTTTTTGTT
TAACGTATGTAATTTAAAAGGTGATTGGAGTATGAGTTCTTTTGCAGAGCAGCAAATAAAAGCTATAAAGGAAAAAGTGG
GAGATAAAAAAGTAATATGCGCTCTATCAGGTGGAGTAGATTCATCAGTAGCAGCAGTAATTGTTCATAAAGCTATAGGG
AAACAATTAACTTGTATATTTGTTGATCATGGCTTACTTAGAAAAGATGAAGGAGATCAAGTAGAAAAAATATTTAAAGA
TCAATTTGATATGAATTTAATAAGAGTTAATGCTCAAGATAGATTTTTAGGAAAATTAAAAGGAGTTTCAGATCCAGAAA
GAAAAAGAAAAATAATTGGAGAAGAATTTATAAGAGTATTTGAAGAAGAAGCTAAAAAATTAGGTGATATAAGTTTCTTA
GTTCAAGGTACTATATATCCTGATATAGTAGAAAGCGGAACAAACACATCAGCTACTATAAAAAGTCACCACAATGTAGG
TGGACTACCAGAAGATATGGAATTTAAATTAATAGAACCTTTAAGAGAATTGTTTAAAGATGAAGTAAGAGCTGTTGGAG
AAGAATTAGGTATACCACATAAATTAGTATGGAGACAGCCATTCCCAGGACCAGGCTTAGCTATAAGAGTATTAGGTGAG
GTTACAGAGGAAAAATTAGCTATTACAAGAGAAGCAGATGCTATATTCAGAGAAGAGATAGCTAAAGCAGGCCTAGAAGA
AAAGATATGGCAATATTTTGCCTGCCTTCCAAATATACAGTCAGTAGGAGTAATGGGAGATGAAAGAACATATTGCCATA
CAATAGCATTAAGAGCTGTTACATCTTCAGATGCAATGACTTCAGATTGGGCAAGAATACCTTATGAAGTATTAGATAAA
GTATCAAGAAGAATAGTAAATGAGGTTAAAGAAGTAAACAGAATTGTTTATGATGTAACTTCAAAACCACCAGCAACTAT
TGAATGGGAATAA

Upstream 100 bases:

>100_bases
AATTCAAACATCTTCAGGGATAAGAGAAAGTCATCCTCATGATATTTCAATAACAAAAGAAGCGCCAAATTATAGCGTTA
ATCAATAAAAGGAGGCACAT

Downstream 100 bases:

>100_bases
AATAAAGTTTAGTAAAGTTAATATTTAGATCATATAAAAAGTGCTTTCAATATTTACTTGTATAAAAGTGAATTGAAAGC
ACTTTGTATTTTTTTGTAAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Sequences:

>Translated_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
>Mature_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGDISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=35.4661791590494, Blast_Score=303, Evalue=2e-82,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=50.6717850287908, Blast_Score=553, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI133901714, Length=568, Percent_Identity=36.2676056338028, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992717, Length=568, Percent_Identity=36.2676056338028, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=568, Percent_Identity=36.2676056338028, Blast_Score=312, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=52.7131782945737, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=35.6617647058824, Blast_Score=308, Evalue=7e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57500; Mature: 57500

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHEEEEEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC
>Mature Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENAEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHEEEEEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGDISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA