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The map label for this gene is uvrC

Identifier: 170756327

GI number: 170756327

Start: 3687961

End: 3689817

Strand: Reverse

Name: uvrC

Synonym: CLD_1128

Alternate gene names: 170756327

Gene position: 3689817-3687961 (Counterclockwise)

Preceding gene: 170755514

Following gene: 170755437

Centisome position: 93.22

GC content: 27.14

Gene sequence:

>1857_bases
GTGTTTGATTTAGAATACCAATTAAAAAACCTGCCAGATAAACCTGGAGTATATTTAATGAAAAATAATTTAGGGGAAAT
TATTTATGTAGGGAAAGCAAAAATATTAAAAAATAGAGTAAGGCAATATTTTCAAAAATCACAAAAACATTCTGAAAAGG
TTAAGGCTATGGTGAAAAATATAGAAGAGTTTGAGTATATAATTACAGACTCAGAAATAGAAGCTTTAATATTAGAGTGT
AATTTAATAAAAAAATATAGACCAAAATACAATATTCTTTTAAAGGATGATAAACATTATCCTTTTATAAAAGTTACATT
AGCTGAGGACTTTCCAAGGGTAGTTTCTACAAGAAAGGTTACAAAGGATGGAAGTAAATATTTTGGGCCTTATGTAGATG
GAAGTTCTGTAAAAGATATTATAGAATTAATAAAAAAGACTTTCCCAATAAGAACTTGCAAGAAAAATATAGTAGAGGGG
GCTAAGGCTATAAGACCTTGTCTAAATTATCAAATAGGACTATGCAAAGCTCCTTGCGCTCAGTATATAAAAAAAAGTGA
GTATAGAGAAATTATAGATGATGTTATAAAATTATTATCAGGAAAACATCTAGATATAGTAGAAAATTTTAAACTAAACA
TGGAAAAGGCAGCGGAAAATTTAGAATTTGAAAAAGCAGCTATGTTAAGAGACAAAATAAATATAATAGAAAAAATAGGT
GAAAAACAAAAAATAATTTTAAATAATTTTGACAATGAAGATTACATATCATTATATAGTGATGGAAAGGATACATGTTT
TCAAGTATTCTTTTTAAGAAATGGAAAAATAGTTGGAAGGGAACATTTTATTATAGAAGATACTTTTGATACTAATTCTT
CTACATTGATTTCTAATTTTTTAAAAGAATTTTATGGAGGCACTGCTTATATTCCTAAAACGATATATGTGCCTAGCATA
GAAGATGAAGCATTACTAGAGCAGTGGCTTACATTAAAAAAGGAAAGTAAATCTACAATTAAAATTCCTATAAAAGGGGA
AAAGAAAAACATATTAGTTTTGGTAGAAAAAAATGCTAAAACCACATTAGAAAATTTTAAATTAAAATATTTACAAGAAA
AGGCTTTATATGATAATGTTTTGAAGGATTTAAAAAATATATTAAGATTACAAGAAGAACCTATAAGAATTGAAGCCTTT
GATATATCTAATATACAAGGATTTGATTCTGTAGGCAGTATGGTAGTCTTTGAAAAAGGAAGAGCGAAACCTAGTGATTA
TAGAAGATTTAAGATAAACACGGTAAAGGGTGCTGATGATTACAAAAGCATGAAGGAAATATTAACCAGAAGGTTTCAGC
ATGGTTTAAGTGAAATAAAGTCTATACAGGATAGAAAGTTAGAGTTTAGTTCAGGAAAGTTTTCTGTTTTCCCAGATTTA
ATATTAATGGATGGCGGAAAAGGACAAATAAATATTGCACTTGAGGTTCTAAATACCTTTAATATAGATATACCCGTTTG
TGGTATGGTTAAAGATAATAAACATAGAACTAGAGGTTTAATTTATAACGGAGAGGAAATAATTATAAATAAATATGGAA
GTGTTATGAAGTTTATTACTAGGGTACAAGATGAAGTTCATAGGTTTGCTATAAGTTATCATAGGAGTTTAAGAGGAAAA
AATAGTTTTCACTCTTTGTTAGATGATATTCCAAATATAGGAGAAAAAAGAAAAAAAGATTTGCTTTTTAATTTTAAAAG
TATAGATAACATAAAAAAAGCAACCTATGAAGAACTTTTAAGCATACCATCTATGGATAAGAAGTCAGCTGAGTGTGTGC
TTGAATTTTTTAAATAA

Upstream 100 bases:

>100_bases
AAAATAGCCACATTAATAGAAACTATACTAACTACTTCGGTTTTAATATTTACAATATATAAATTACCAATAATTTTTCC
CAAATAATAGGAGTGATTAA

Downstream 100 bases:

>100_bases
AAATTGTTTTTTACTAGAAAGTATAAAATTATTGAGAGAAGGGTTAAAGTGAGATATTTAGTAGATACACATACACATAC
AATAGTAAGTGGGCATGCAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEG
AKAIRPCLNYQIGLCKAPCAQYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPSI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK

Sequences:

>Translated_618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEG
AKAIRPCLNYQIGLCKAPCAQYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPSI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK
>Mature_618_residues
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKNIEEFEYIITDSEIEALILEC
NLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKVTKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEG
AKAIRPCLNYQIGLCKAPCAQYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNFLKEFYGGTAYIPKTIYVPSI
EDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAKTTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAF
DISNIQGFDSVGSMVVFEKGRAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
ILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFITRVQDEVHRFAISYHRSLRGK
NSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELLSIPSMDKKSAECVLEFFK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=631, Percent_Identity=33.122028526149, Blast_Score=336, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71615; Mature: 71615

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKN
CCCCCCHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKV
HHHHHEEEECCHHHEEEHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHH
TKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEGAKAIRPCLNYQIGLCKAPCA
CCCCCHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCC
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNF
CCCEEEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCEEEEEEECCCCCCHHHHHHH
LKEFYGGTAYIPKTIYVPSIEDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAK
HHHHCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCH
TTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCEEEEECC
RAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCE
ILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFIT
EEEECCCCEEEEEEEEEHHCCCCCCEECCEECCCCCCCCEEECCCEEEEEHHHHHHHHHH
RVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHEEHHHHHHHHHHHHHHHH
SIPSMDKKSAECVLEFFK
CCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MFDLEYQLKNLPDKPGVYLMKNNLGEIIYVGKAKILKNRVRQYFQKSQKHSEKVKAMVKN
CCCCCCHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEEFEYIITDSEIEALILECNLIKKYRPKYNILLKDDKHYPFIKVTLAEDFPRVVSTRKV
HHHHHEEEECCHHHEEEHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHH
TKDGSKYFGPYVDGSSVKDIIELIKKTFPIRTCKKNIVEGAKAIRPCLNYQIGLCKAPCA
CCCCCHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QYIKKSEYREIIDDVIKLLSGKHLDIVENFKLNMEKAAENLEFEKAAMLRDKINIIEKIG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCC
EKQKIILNNFDNEDYISLYSDGKDTCFQVFFLRNGKIVGREHFIIEDTFDTNSSTLISNF
CCCEEEEECCCCCCEEEEECCCCCCEEEEEEEECCEEECCEEEEEEECCCCCCHHHHHHH
LKEFYGGTAYIPKTIYVPSIEDEALLEQWLTLKKESKSTIKIPIKGEKKNILVLVEKNAK
HHHHCCCCEECCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCH
TTLENFKLKYLQEKALYDNVLKDLKNILRLQEEPIRIEAFDISNIQGFDSVGSMVVFEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCEEEEECC
RAKPSDYRRFKINTVKGADDYKSMKEILTRRFQHGLSEIKSIQDRKLEFSSGKFSVFPDL
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCE
ILMDGGKGQINIALEVLNTFNIDIPVCGMVKDNKHRTRGLIYNGEEIIINKYGSVMKFIT
EEEECCCCEEEEEEEEEHHCCCCCCEECCEECCCCCCCCEEECCCEEEEEHHHHHHHHHH
RVQDEVHRFAISYHRSLRGKNSFHSLLDDIPNIGEKRKKDLLFNFKSIDNIKKATYEELL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHEEHHHHHHHHHHHHHHHH
SIPSMDKKSAECVLEFFK
CCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA