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The map label for this gene is fabI1 [H]

Identifier: 170751893

GI number: 170751893

Start: 5839358

End: 5840182

Strand: Direct

Name: fabI1 [H]

Synonym: Mrad2831_5525

Alternate gene names: 170751893

Gene position: 5839358-5840182 (Clockwise)

Preceding gene: 170751892

Following gene: 170751896

Centisome position: 96.08

GC content: 67.52

Gene sequence:

>825_bases
ATGGCGGAACACGGGCAGGGCCTTCTGGCGGGCAAGCGGGGCATCGTCCTCGGGGTCGCCAACAACCGCTCGATCGCCTG
GGGCATCGCCCGCAGCGCCCGCGCCCACGGGGCCGAACTGGCCTTCACCTACCAGGGCGACGCCCTGCGCAAGCGCGTGG
AGCCCCTCGCCAAGGAACTCGACGCCCACGTGATCGGGCACTGCGACGTCACCGAGTCGGCCACGATCGACGCGGTCTTC
GCGGAGGCCGCGAAGGTCTTCCCCGACGGCATCGACTTCGTCGTTCACTGCGTCGCCTTCTCCGACAAGGACGAGCTGAC
GGGCCGCTACATCGAGACCTCCGAGGACAACTTTACCAAGTCGCTCCTGGTCTCGTGCTACTCGTTCACCGCGGTGGCCC
AGCGCGCCGAGAAGATCATGCGCCCGGGCGGCTCACTGGTGACGCTGACCTATTACGGCGCCGAGAAGTGGATGCCGCAC
TACAACGTCATGGGCGTCGCCAAGGCGGCGCTGGAGGCGTCGGTGCGCTACCTCGCGGCCGATCTCGGACCGAAGAACAT
CCGGGTCAACGCGATCTCGGCCGGCCCGATCAAGACCCTCGCCGCCTCGGGCATCGGCGATTTCCGCTACATCCTGAAGT
GGAACGAGTACAACGCGCCCCTGCGCCGGACCGTGACGATCGGCGAGGTCGGCGAGACCGCGTCCTACCTCGTCTCCGAC
ATGGCGGCCGGGATGACCGGCGAGATCCTCCACGTGGATGCCGGCTACCACGTGGTTGGCATGAAGAACCCCGAGGCGCC
GGACCTCACCCTCGACAAGGATTGA

Upstream 100 bases:

>100_bases
CTGACCGCGCTCGGTGGCGTCCCGGACTTCCGTCGCCGGGCCGCCTCCGCTAAGGAGGCCCCCCGGCCCCGAGAGGGGTC
GCGCGGCTTCGGGATCGATC

Downstream 100 bases:

>100_bases
GGCCTCGGTCATCGCGGGCGCCGTGATCTGCGACGGCGCGACGGCCTGCGTGGCGCCGTCACCCGGGTCTCTCGGCCGCG
CCCGTGGGGAAGGCGGCGCG

Product: enoyl-acyl carrier protein reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MAEHGQGLLAGKRGIVLGVANNRSIAWGIARSARAHGAELAFTYQGDALRKRVEPLAKELDAHVIGHCDVTESATIDAVF
AEAAKVFPDGIDFVVHCVAFSDKDELTGRYIETSEDNFTKSLLVSCYSFTAVAQRAEKIMRPGGSLVTLTYYGAEKWMPH
YNVMGVAKAALEASVRYLAADLGPKNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIGEVGETASYLVSD
MAAGMTGEILHVDAGYHVVGMKNPEAPDLTLDKD

Sequences:

>Translated_274_residues
MAEHGQGLLAGKRGIVLGVANNRSIAWGIARSARAHGAELAFTYQGDALRKRVEPLAKELDAHVIGHCDVTESATIDAVF
AEAAKVFPDGIDFVVHCVAFSDKDELTGRYIETSEDNFTKSLLVSCYSFTAVAQRAEKIMRPGGSLVTLTYYGAEKWMPH
YNVMGVAKAALEASVRYLAADLGPKNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIGEVGETASYLVSD
MAAGMTGEILHVDAGYHVVGMKNPEAPDLTLDKD
>Mature_273_residues
AEHGQGLLAGKRGIVLGVANNRSIAWGIARSARAHGAELAFTYQGDALRKRVEPLAKELDAHVIGHCDVTESATIDAVFA
EAAKVFPDGIDFVVHCVAFSDKDELTGRYIETSEDNFTKSLLVSCYSFTAVAQRAEKIMRPGGSLVTLTYYGAEKWMPHY
NVMGVAKAALEASVRYLAADLGPKNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIGEVGETASYLVSDM
AAGMTGEILHVDAGYHVVGMKNPEAPDLTLDKD

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=50.3846153846154, Blast_Score=265, Evalue=2e-72,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29507; Mature: 29376

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEHGQGLLAGKRGIVLGVANNRSIAWGIARSARAHGAELAFTYQGDALRKRVEPLAKEL
CCCCCCEEEECCCEEEEEECCCCEEEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
DAHVIGHCDVTESATIDAVFAEAAKVFPDGIDFVVHCVAFSDKDELTGRYIETSEDNFTK
CCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHCCCCEEECCCCHHHH
SLLVSCYSFTAVAQRAEKIMRPGGSLVTLTYYGAEKWMPHYNVMGVAKAALEASVRYLAA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHH
DLGPKNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIGEVGETASYLVSD
CCCCCCEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHH
MAAGMTGEILHVDAGYHVVGMKNPEAPDLTLDKD
HHCCCCCCEEEEECCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AEHGQGLLAGKRGIVLGVANNRSIAWGIARSARAHGAELAFTYQGDALRKRVEPLAKEL
CCCCCEEEECCCEEEEEECCCCEEEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
DAHVIGHCDVTESATIDAVFAEAAKVFPDGIDFVVHCVAFSDKDELTGRYIETSEDNFTK
CCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHCCCCEEECCCCHHHH
SLLVSCYSFTAVAQRAEKIMRPGGSLVTLTYYGAEKWMPHYNVMGVAKAALEASVRYLAA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHH
DLGPKNIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIGEVGETASYLVSD
CCCCCCEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHH
MAAGMTGEILHVDAGYHVVGMKNPEAPDLTLDKD
HHCCCCCCEEEEECCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]