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The map label for this gene is htpG

Identifier: 170751835

GI number: 170751835

Start: 5779975

End: 5781807

Strand: Direct

Name: htpG

Synonym: Mrad2831_5467

Alternate gene names: 170751835

Gene position: 5779975-5781807 (Clockwise)

Preceding gene: 170751834

Following gene: 170751836

Centisome position: 95.1

GC content: 70.92

Gene sequence:

>1833_bases
GTGAGCGAGACGATCGAGCGGCACGAGTTCGGGGCGGAGGTGGGTCGCCTCCTCGACCTCGTCGTGCACGCGCTCTACTC
CGACCGCGAGATCTTCCTGCGCGAACTCGTCGCCAACGCCGCCGACGCCATGGACCGGCGGCGATTCGAGGCGCTGACCT
CGGCGGCGAGCGCCCTGCCGCCGGATGCCAAGGTCCGAATCGCGCCCGACAAGGAGGCGCGGACCCTGACCGTTTCGGAC
GCCGGCATCGGCATGACCAAGGAGGATCTCGCCACCAACCTCGGGACCATCGCGCGCTCCGGCACGCGGGCCTTCTCGCA
GACGCTGGAATCCGCCAAGGCCGAGGACCGGCCGAGCCTGATCGGCCAGTTCGGCGTCGGCTTCTACTCGGCCTTCATGG
TCGCCGACCGCGTCACCGTCACGTCGCGCCGCGCCGGCAGCGACGAGGCTTGGACCTGGGCCTCGGAGGGGCAGGGCAGC
TACACGCTGGAGCCGGCCACGCGGGCCGAACCCGGCACCGACATCGTCCTGCACCTCAAGGCGGATGCCGACGAGTACCT
CGAGCCCTACCGCCTCGACCATCTCGTGCGGAAATGGGCCGACTTCATCACCGTGCCGATCGCCGTCGTGCGCGACGGCA
AGGACGAGTCGGCCAATCAGGGCACCGCGCTCTGGCGCAAGGCGAAGTCCGAGGTCACCGAGGAGCAGTACGAGGAATTC
TACCACTCCATCGGCATGAACTTCGACAAGCCGTGGGCGACGCTTCACTGGCGCGCCGAGGGTCAGCTCGAGTTCTCCGC
CCTGCTCTTCATCCCCGGCTCGAAGCCGTTCCAGGCCCTCGAGAACGAGCGGCAGAGCAAGGTCCGGCTCCATGTCCGAC
GGATGTTCATCACCGACGAGGCCGAACTGCTGCCGCCGTGGCTGCGCTTCGTCCAAGGCGTGGTCGACACCGAGGACCTG
CCGCTGAACGTCTCCCGCGAGATGCTGCAGTCGACCCCGGCGCTCGCCCGGATCCGCCGCGCGGTTACCGGGCGCGTCGT
CTCCGAACTCACCACCCGCGCCAAGGACGCGGAGGGCTACCAGTCCTTCTGGGAGAACTTCGGCCCCGTCCTCAAGGAGG
GCATCTACGAGGATTTCGAGCGTCGGGGCGAGATCGCGCCGCTCCTGCGCTTCCGCTCCTCGGCGGTGGAGGGCTGGACC
TCGCTGCCCGACTACGTGTCCCGCATGAAGGACGGCCAGGAGGCGATCTACTACCTCGTCGCCGACGATGCCGAGGCGCT
GAAGTCGTCGCCGCAACTGGAGGGCTTCCGGGCCCGCGGCCTCGAGGTGCTGCTCCTCTCCGACCACGTCGACGCCTTCT
GGCCCGATCAGCTCGGCACCTTCGACGGGAAGCCGCTCCGCTCGATCACCAAGGGGGGGCTCGACCTCTCGAAGTTCGCG
CTCGAGGGCGAGCAGCCGGAGGCGCCCGAGGGCATCGACGCCTTCGTCGCCGCCGTGAAGACGGCCCTCGGCGCCGAGGT
CTCGGACGTGCGCACCACCGACCGGCTCGTGGATTCGGCCGTGGTTCTCTCGGCCGGCAGCGGCGGGCCCGACTTGCAGA
TGCAGCGGCTCATGCGCCGGGCCGGGCGGGCCGGCGCCGGGCAGCCGGTTCTGGAGATCAACCCGCGCCACCCGCTGATC
CGGGCGCTGGCCGCGGCGCCCGAATCGGAGGTGCCGCAGGCCGCCGGCACGCTCCTCGACCTCGCCCGCATCCAGGACGG
CGACAGCCCCCGCGACCCGGCGGCCTTCGCCCGCACGGTGGCGGCGGCCCTCGCGGCCGCGCGGGGCGCGTAG

Upstream 100 bases:

>100_bases
CGCGCTGCGGAGGCCGAGGCCGGCCGTCTTTCGCATTGAAAACGGCCCCGTTCGCCAGCATATCGCCACCGCAATTTCCC
CCACAGCGGAGGCATCACCC

Downstream 100 bases:

>100_bases
GACTACGGAGACCCGCGCCGCGCGCCGCCGGGAGGCCGCGCGCGGCGTGTGTCTCCACACACCTCCGTTCGGGATGATTG
TGGGTTCGGTTGATCATTCG

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSETIERHEFGAEVGRLLDLVVHALYSDREIFLRELVANAADAMDRRRFEALTSAASALPPDAKVRIAPDKEARTLTVSD
AGIGMTKEDLATNLGTIARSGTRAFSQTLESAKAEDRPSLIGQFGVGFYSAFMVADRVTVTSRRAGSDEAWTWASEGQGS
YTLEPATRAEPGTDIVLHLKADADEYLEPYRLDHLVRKWADFITVPIAVVRDGKDESANQGTALWRKAKSEVTEEQYEEF
YHSIGMNFDKPWATLHWRAEGQLEFSALLFIPGSKPFQALENERQSKVRLHVRRMFITDEAELLPPWLRFVQGVVDTEDL
PLNVSREMLQSTPALARIRRAVTGRVVSELTTRAKDAEGYQSFWENFGPVLKEGIYEDFERRGEIAPLLRFRSSAVEGWT
SLPDYVSRMKDGQEAIYYLVADDAEALKSSPQLEGFRARGLEVLLLSDHVDAFWPDQLGTFDGKPLRSITKGGLDLSKFA
LEGEQPEAPEGIDAFVAAVKTALGAEVSDVRTTDRLVDSAVVLSAGSGGPDLQMQRLMRRAGRAGAGQPVLEINPRHPLI
RALAAAPESEVPQAAGTLLDLARIQDGDSPRDPAAFARTVAAALAAARGA

Sequences:

>Translated_610_residues
MSETIERHEFGAEVGRLLDLVVHALYSDREIFLRELVANAADAMDRRRFEALTSAASALPPDAKVRIAPDKEARTLTVSD
AGIGMTKEDLATNLGTIARSGTRAFSQTLESAKAEDRPSLIGQFGVGFYSAFMVADRVTVTSRRAGSDEAWTWASEGQGS
YTLEPATRAEPGTDIVLHLKADADEYLEPYRLDHLVRKWADFITVPIAVVRDGKDESANQGTALWRKAKSEVTEEQYEEF
YHSIGMNFDKPWATLHWRAEGQLEFSALLFIPGSKPFQALENERQSKVRLHVRRMFITDEAELLPPWLRFVQGVVDTEDL
PLNVSREMLQSTPALARIRRAVTGRVVSELTTRAKDAEGYQSFWENFGPVLKEGIYEDFERRGEIAPLLRFRSSAVEGWT
SLPDYVSRMKDGQEAIYYLVADDAEALKSSPQLEGFRARGLEVLLLSDHVDAFWPDQLGTFDGKPLRSITKGGLDLSKFA
LEGEQPEAPEGIDAFVAAVKTALGAEVSDVRTTDRLVDSAVVLSAGSGGPDLQMQRLMRRAGRAGAGQPVLEINPRHPLI
RALAAAPESEVPQAAGTLLDLARIQDGDSPRDPAAFARTVAAALAAARGA
>Mature_609_residues
SETIERHEFGAEVGRLLDLVVHALYSDREIFLRELVANAADAMDRRRFEALTSAASALPPDAKVRIAPDKEARTLTVSDA
GIGMTKEDLATNLGTIARSGTRAFSQTLESAKAEDRPSLIGQFGVGFYSAFMVADRVTVTSRRAGSDEAWTWASEGQGSY
TLEPATRAEPGTDIVLHLKADADEYLEPYRLDHLVRKWADFITVPIAVVRDGKDESANQGTALWRKAKSEVTEEQYEEFY
HSIGMNFDKPWATLHWRAEGQLEFSALLFIPGSKPFQALENERQSKVRLHVRRMFITDEAELLPPWLRFVQGVVDTEDLP
LNVSREMLQSTPALARIRRAVTGRVVSELTTRAKDAEGYQSFWENFGPVLKEGIYEDFERRGEIAPLLRFRSSAVEGWTS
LPDYVSRMKDGQEAIYYLVADDAEALKSSPQLEGFRARGLEVLLLSDHVDAFWPDQLGTFDGKPLRSITKGGLDLSKFAL
EGEQPEAPEGIDAFVAAVKTALGAEVSDVRTTDRLVDSAVVLSAGSGGPDLQMQRLMRRAGRAGAGQPVLEINPRHPLIR
ALAAAPESEVPQAAGTLLDLARIQDGDSPRDPAAFARTVAAALAAARGA

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI20149594, Length=678, Percent_Identity=35.2507374631268, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI155722983, Length=593, Percent_Identity=37.9426644182125, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI154146191, Length=410, Percent_Identity=34.8780487804878, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI153792590, Length=410, Percent_Identity=34.8780487804878, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4507677, Length=386, Percent_Identity=34.1968911917098, Blast_Score=216, Evalue=6e-56,
Organism=Escherichia coli, GI1786679, Length=623, Percent_Identity=43.338683788122, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17559162, Length=639, Percent_Identity=36.9327073552426, Blast_Score=414, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17542208, Length=667, Percent_Identity=34.9325337331334, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI115535205, Length=605, Percent_Identity=34.5454545454545, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI115535167, Length=431, Percent_Identity=38.2830626450116, Blast_Score=286, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323840, Length=407, Percent_Identity=35.8722358722359, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6325016, Length=407, Percent_Identity=35.8722358722359, Blast_Score=257, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24586016, Length=591, Percent_Identity=37.3942470389171, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI21357739, Length=650, Percent_Identity=34.7692307692308, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI17647529, Length=361, Percent_Identity=36.8421052631579, Blast_Score=258, Evalue=1e-68,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_METRJ (B1LZG0)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001758095.1
- ProteinModelPortal:   B1LZG0
- GeneID:   6141541
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_5467
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- ProtClustDB:   PRK05218
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67040; Mature: 66909

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETIERHEFGAEVGRLLDLVVHALYSDREIFLRELVANAADAMDRRRFEALTSAASALP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDAKVRIAPDKEARTLTVSDAGIGMTKEDLATNLGTIARSGTRAFSQTLESAKAEDRPSL
CCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGQFGVGFYSAFMVADRVTVTSRRAGSDEAWTWASEGQGSYTLEPATRAEPGTDIVLHLK
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEECCCCCCCEEECCCCCCCCCCCEEEEEE
ADADEYLEPYRLDHLVRKWADFITVPIAVVRDGKDESANQGTALWRKAKSEVTEEQYEEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YHSIGMNFDKPWATLHWRAEGQLEFSALLFIPGSKPFQALENERQSKVRLHVRRMFITDE
HHHHCCCCCCCCEEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AELLPPWLRFVQGVVDTEDLPLNVSREMLQSTPALARIRRAVTGRVVSELTTRAKDAEGY
HHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QSFWENFGPVLKEGIYEDFERRGEIAPLLRFRSSAVEGWTSLPDYVSRMKDGQEAIYYLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEE
ADDAEALKSSPQLEGFRARGLEVLLLSDHVDAFWPDQLGTFDGKPLRSITKGGLDLSKFA
ECCHHHHHCCCCCCCHHHCCEEEEEEECCCCCCCCHHCCCCCCCHHHHHHHCCCCHHHHH
LEGEQPEAPEGIDAFVAAVKTALGAEVSDVRTTDRLVDSAVVLSAGSGGPDLQMQRLMRR
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
AGRAGAGQPVLEINPRHPLIRALAAAPESEVPQAAGTLLDLARIQDGDSPRDPAAFARTV
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AAALAAARGA
HHHHHHHCCC
>Mature Secondary Structure 
SETIERHEFGAEVGRLLDLVVHALYSDREIFLRELVANAADAMDRRRFEALTSAASALP
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDAKVRIAPDKEARTLTVSDAGIGMTKEDLATNLGTIARSGTRAFSQTLESAKAEDRPSL
CCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGQFGVGFYSAFMVADRVTVTSRRAGSDEAWTWASEGQGSYTLEPATRAEPGTDIVLHLK
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEECCCCCCCEEECCCCCCCCCCCEEEEEE
ADADEYLEPYRLDHLVRKWADFITVPIAVVRDGKDESANQGTALWRKAKSEVTEEQYEEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YHSIGMNFDKPWATLHWRAEGQLEFSALLFIPGSKPFQALENERQSKVRLHVRRMFITDE
HHHHCCCCCCCCEEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AELLPPWLRFVQGVVDTEDLPLNVSREMLQSTPALARIRRAVTGRVVSELTTRAKDAEGY
HHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QSFWENFGPVLKEGIYEDFERRGEIAPLLRFRSSAVEGWTSLPDYVSRMKDGQEAIYYLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEE
ADDAEALKSSPQLEGFRARGLEVLLLSDHVDAFWPDQLGTFDGKPLRSITKGGLDLSKFA
ECCHHHHHCCCCCCCHHHCCEEEEEEECCCCCCCCHHCCCCCCCHHHHHHHCCCCHHHHH
LEGEQPEAPEGIDAFVAAVKTALGAEVSDVRTTDRLVDSAVVLSAGSGGPDLQMQRLMRR
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
AGRAGAGQPVLEINPRHPLIRALAAAPESEVPQAAGTLLDLARIQDGDSPRDPAAFARTV
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AAALAAARGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA