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The map label for this gene is ywrD [H]

Identifier: 170751459

GI number: 170751459

Start: 5394315

End: 5395916

Strand: Reverse

Name: ywrD [H]

Synonym: Mrad2831_5078

Alternate gene names: 170751459

Gene position: 5395916-5394315 (Counterclockwise)

Preceding gene: 170751460

Following gene: 170751457

Centisome position: 88.78

GC content: 73.35

Gene sequence:

>1602_bases
GTGAGAGACTTCTCCGCCCCCGGCCGCTCCCCGGTCTACGCCGCCAACGCCGCCGTCGCGACCTCGCACCCGCTGTCGAC
GCTCGCCGCCGTCGAGGTGCTGCGCGCGGGCGGCAACGCCGTCGATGCCGGCATCGCGGCGGTGGCCGTGCAATGCGTGG
TCGATCCGCTGATGACCGGCATCGGCGGCGACTGCTTCGCCCTCTACGCCCCCGCCGGCGCCAGCAAGCCGATCGCCCTC
GACGGCTCGGGCCGGGCGCCGGCCGCCGCCACACCCGAATGGTACGCCGAGCACGGCGTCGGGATCACGCCGACCTCGCC
GCACGCCGTGACGGTGCCGGGCGCGGTCGCGGCCTGGGACCTGCTGGTACGCGAGCACGGCACCCGCTCCCTCGGCGAGC
TGCTCCAGCCGGCGATCCGCTACGCGGAGGACGGGTTCGTCGTCCAGCAGCGGGTGGGCTGGGACTGGCTGCGCGGCGCC
GAGCGCGTCGCCGCGGACCCGCACGCCGCCGAGACCTACCTGCCCGGCGGGAGACCGCCGGCGATCGGCAGCGTCGTCCG
TCTGCCGAAGCTCGCCGCGACGCTCCGGGCGATCGCCGAGGCGGGTGCGCGCGCCTTCTACACGGGCCCCGTCGCCGAGG
ACATGGTGAGCCGGCTGAACGCCCTCGGCGGCCTGCACACCCTGGACGACTTCGCGGCCGCCAAGCCCGACATCGTCACG
CCGGTCTCGACCCGCTACCGCGGCTACGACGTCTACGAGTGCCCGCCCGCCGGCCAGGGGTTGGCGGCGCTGATGATGCT
CAACGTGCTCTCGCACTACGACGTCGGCGCCCTCTCGGACCTCGACCGGCTCCACCTCTTCGCCGAGGTGTGCAAGCAGG
GCTACCATCACCGCGACGTCCTGTTCGGCGACGCCGCCCTCGCCAACGTGCCGATCGAGCACCTGCTCTCCGACGCCTGG
AAAGCCGCCGCCCACGGGGCGATCGACATGGGCCGGGCCCGGGAGCCTGAGATCTATCCCGAGATCGCCCGCGAGATGGT
CGAGGGCCGCGCCCACAAGGACACGGTCTATCTCTGCGTGGTCGACCGGAACGGCAACGCGCTGTCGCTGATCAACTCGA
TCTTCCAGGGCTTCGGCTCCGGCATCCTGGCACCCGAGAGCGGCGTGCTGCTGCACAACCGCGGCCTGTCGTTCCGGACC
GAGGGCGGCCACCCGAACAGCGTCGGGCCGGCCAAGCGGCCGATGCACACGATCATCCCGGGCATGCTGATGAAGGACGG
GCAGGCCGTCGCGCCGTTCGGCGTCATGGGCGGCCACTACCAGGCCATGGGCCATGTCGAGCTGCTCTCCGGCCTGCTCG
ACCGGGGCCTCGACGTGCAGGAGGCCCTCGATGCGCCGCGCAGCTTCGCCTACGGCGGCAGCCTGGAGGTGGAAGGCGGG
ATCCCCGATGCGGTGATGGCGGGGCTCAAGGAGCGCGGCCACCCGGCGATCCGCGCGCCGCTGCCGCTCGGCGGCGGCCA
GATCATCTGGATCGACCGGAAGGCCGGCACGCTGGCGGCGGGCTCGGACCCGCGCAAGGATGGGGCGGCGCTGGGGTATT
GA

Upstream 100 bases:

>100_bases
CCTCCGAGGCCTCCGCTGCGCTCAGGCACCTCAGAATGAGGTCGCGTCTTGGATCAAGCCATCCCGTCTCCCTGAGGCGG
TCATCACAGCAGGACATCCC

Downstream 100 bases:

>100_bases
TGCGTGTGTGAGGATGGGCGCCTCCGGCGCTCATCCTTCGGTGCGGGCAACGGCGAGCCTTGTCAGCACATCGTCTTTGC
GAGCGGAGCGAAGCGATCCC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MRDFSAPGRSPVYAANAAVATSHPLSTLAAVEVLRAGGNAVDAGIAAVAVQCVVDPLMTGIGGDCFALYAPAGASKPIAL
DGSGRAPAAATPEWYAEHGVGITPTSPHAVTVPGAVAAWDLLVREHGTRSLGELLQPAIRYAEDGFVVQQRVGWDWLRGA
ERVAADPHAAETYLPGGRPPAIGSVVRLPKLAATLRAIAEAGARAFYTGPVAEDMVSRLNALGGLHTLDDFAAAKPDIVT
PVSTRYRGYDVYECPPAGQGLAALMMLNVLSHYDVGALSDLDRLHLFAEVCKQGYHHRDVLFGDAALANVPIEHLLSDAW
KAAAHGAIDMGRAREPEIYPEIAREMVEGRAHKDTVYLCVVDRNGNALSLINSIFQGFGSGILAPESGVLLHNRGLSFRT
EGGHPNSVGPAKRPMHTIIPGMLMKDGQAVAPFGVMGGHYQAMGHVELLSGLLDRGLDVQEALDAPRSFAYGGSLEVEGG
IPDAVMAGLKERGHPAIRAPLPLGGGQIIWIDRKAGTLAAGSDPRKDGAALGY

Sequences:

>Translated_533_residues
MRDFSAPGRSPVYAANAAVATSHPLSTLAAVEVLRAGGNAVDAGIAAVAVQCVVDPLMTGIGGDCFALYAPAGASKPIAL
DGSGRAPAAATPEWYAEHGVGITPTSPHAVTVPGAVAAWDLLVREHGTRSLGELLQPAIRYAEDGFVVQQRVGWDWLRGA
ERVAADPHAAETYLPGGRPPAIGSVVRLPKLAATLRAIAEAGARAFYTGPVAEDMVSRLNALGGLHTLDDFAAAKPDIVT
PVSTRYRGYDVYECPPAGQGLAALMMLNVLSHYDVGALSDLDRLHLFAEVCKQGYHHRDVLFGDAALANVPIEHLLSDAW
KAAAHGAIDMGRAREPEIYPEIAREMVEGRAHKDTVYLCVVDRNGNALSLINSIFQGFGSGILAPESGVLLHNRGLSFRT
EGGHPNSVGPAKRPMHTIIPGMLMKDGQAVAPFGVMGGHYQAMGHVELLSGLLDRGLDVQEALDAPRSFAYGGSLEVEGG
IPDAVMAGLKERGHPAIRAPLPLGGGQIIWIDRKAGTLAAGSDPRKDGAALGY
>Mature_533_residues
MRDFSAPGRSPVYAANAAVATSHPLSTLAAVEVLRAGGNAVDAGIAAVAVQCVVDPLMTGIGGDCFALYAPAGASKPIAL
DGSGRAPAAATPEWYAEHGVGITPTSPHAVTVPGAVAAWDLLVREHGTRSLGELLQPAIRYAEDGFVVQQRVGWDWLRGA
ERVAADPHAAETYLPGGRPPAIGSVVRLPKLAATLRAIAEAGARAFYTGPVAEDMVSRLNALGGLHTLDDFAAAKPDIVT
PVSTRYRGYDVYECPPAGQGLAALMMLNVLSHYDVGALSDLDRLHLFAEVCKQGYHHRDVLFGDAALANVPIEHLLSDAW
KAAAHGAIDMGRAREPEIYPEIAREMVEGRAHKDTVYLCVVDRNGNALSLINSIFQGFGSGILAPESGVLLHNRGLSFRT
EGGHPNSVGPAKRPMHTIIPGMLMKDGQAVAPFGVMGGHYQAMGHVELLSGLLDRGLDVQEALDAPRSFAYGGSLEVEGG
IPDAVMAGLKERGHPAIRAPLPLGGGQIIWIDRKAGTLAAGSDPRKDGAALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=541, Percent_Identity=27.5415896487985, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915090, Length=541, Percent_Identity=27.5415896487985, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915096, Length=541, Percent_Identity=27.5415896487985, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915094, Length=541, Percent_Identity=27.5415896487985, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI113429324, Length=524, Percent_Identity=27.0992366412214, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=26.8431001890359, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI153266885, Length=535, Percent_Identity=24.4859813084112, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI153266901, Length=536, Percent_Identity=24.6268656716418, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI109148539, Length=553, Percent_Identity=26.9439421338156, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI30581157, Length=191, Percent_Identity=32.4607329842932, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI30581155, Length=191, Percent_Identity=32.4607329842932, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=547, Percent_Identity=31.0786106032907, Blast_Score=225, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17506189, Length=530, Percent_Identity=25.2830188679245, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI72000294, Length=489, Percent_Identity=25.1533742331288, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI212646519, Length=489, Percent_Identity=25.1533742331288, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193208245, Length=481, Percent_Identity=24.1164241164241, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193208247, Length=481, Percent_Identity=24.1164241164241, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=521, Percent_Identity=25.5278310940499, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24642670, Length=547, Percent_Identity=26.3254113345521, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24642666, Length=547, Percent_Identity=26.3254113345521, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161077880, Length=547, Percent_Identity=26.3254113345521, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551474, Length=547, Percent_Identity=26.3254113345521, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161077878, Length=547, Percent_Identity=26.3254113345521, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI18859893, Length=524, Percent_Identity=25.763358778626, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077496, Length=411, Percent_Identity=26.7639902676399, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859741, Length=561, Percent_Identity=24.0641711229947, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55770; Mature: 55770

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFSAPGRSPVYAANAAVATSHPLSTLAAVEVLRAGGNAVDAGIAAVAVQCVVDPLMTG
CCCCCCCCCCCEEECCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
IGGDCFALYAPAGASKPIALDGSGRAPAAATPEWYAEHGVGITPTSPHAVTVPGAVAAWD
CCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCHHHHHH
LLVREHGTRSLGELLQPAIRYAEDGFVVQQRVGWDWLRGAERVAADPHAAETYLPGGRPP
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHCCCCCHHHCCCCCCCCC
AIGSVVRLPKLAATLRAIAEAGARAFYTGPVAEDMVSRLNALGGLHTLDDFAAAKPDIVT
CHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PVSTRYRGYDVYECPPAGQGLAALMMLNVLSHYDVGALSDLDRLHLFAEVCKQGYHHRDV
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCE
LFGDAALANVPIEHLLSDAWKAAAHGAIDMGRAREPEIYPEIAREMVEGRAHKDTVYLCV
EECCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
VDRNGNALSLINSIFQGFGSGILAPESGVLLHNRGLSFRTEGGHPNSVGPAKRPMHTIIP
EECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHC
GMLMKDGQAVAPFGVMGGHYQAMGHVELLSGLLDRGLDVQEALDAPRSFAYGGSLEVEGG
CHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCCCCEEECCC
IPDAVMAGLKERGHPAIRAPLPLGGGQIIWIDRKAGTLAAGSDPRKDGAALGY
CCHHHHHHHHHCCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDFSAPGRSPVYAANAAVATSHPLSTLAAVEVLRAGGNAVDAGIAAVAVQCVVDPLMTG
CCCCCCCCCCCEEECCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
IGGDCFALYAPAGASKPIALDGSGRAPAAATPEWYAEHGVGITPTSPHAVTVPGAVAAWD
CCCCEEEEECCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCHHHHHH
LLVREHGTRSLGELLQPAIRYAEDGFVVQQRVGWDWLRGAERVAADPHAAETYLPGGRPP
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHCCCCCHHHCCCCCCCCC
AIGSVVRLPKLAATLRAIAEAGARAFYTGPVAEDMVSRLNALGGLHTLDDFAAAKPDIVT
CHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PVSTRYRGYDVYECPPAGQGLAALMMLNVLSHYDVGALSDLDRLHLFAEVCKQGYHHRDV
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCE
LFGDAALANVPIEHLLSDAWKAAAHGAIDMGRAREPEIYPEIAREMVEGRAHKDTVYLCV
EECCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
VDRNGNALSLINSIFQGFGSGILAPESGVLLHNRGLSFRTEGGHPNSVGPAKRPMHTIIP
EECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHC
GMLMKDGQAVAPFGVMGGHYQAMGHVELLSGLLDRGLDVQEALDAPRSFAYGGSLEVEGG
CHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCCCCEEECCC
IPDAVMAGLKERGHPAIRAPLPLGGGQIIWIDRKAGTLAAGSDPRKDGAALGY
CCHHHHHHHHHCCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]