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The map label for this gene is tauD [C]

Identifier: 170751357

GI number: 170751357

Start: 5296351

End: 5297268

Strand: Reverse

Name: tauD [C]

Synonym: Mrad2831_4976

Alternate gene names: 170751357

Gene position: 5297268-5296351 (Counterclockwise)

Preceding gene: 170751363

Following gene: 170751350

Centisome position: 87.16

GC content: 73.2

Gene sequence:

>918_bases
ATGAGCGCCGTCCCCCAGCCCCTCCACGCGTCTGTCCCCGCCCTCGACATCCGCCGCGTCGCCGGCCGTCTCGGCGCGGA
GATCCGCGGCCTCGCCCTCTCGGGAGACTTGGACGACGGGACGGTCGCGGCGATCCGGCAGGCGCTGAACACCCACAAGG
TGGTGTTCTTCCGCGACCAGGACCTCGACGAGGCCGAGCAGGAGGCCTTCGGCCGGCGCCTCGGCGACCTCGTCGCGCAT
CCGACCGTCCCCTCCCTCGCCGGCACGGCGGGGGTCCTCGACATCGACGGCAGCCGGGGCGAGCGGGCGAGTTCCTGGCA
CACCGACGTGACCTTCGTGCCGGCCTACCCGGCGCTCTCGATCCTGCGGGCCGTGACGCTGCCGCCCTACGGCGGCGACA
CGCTCTGGGCCAACACGGCGGCGGCCTACGCGGACCTGCCCGAGCCCCTGCGCGACCTCGCCGACAAGCTCTGGGCGCTG
CACTCCAACGTCTACGACTATGTCGGCGGCCGGGTGAACGTGTCGGAGGCCGGGCGGCGGCGCTACGACGAGGTGTTCAC
CAAGACCGTGTTCGAGACCGAGCACCCGCTGGTCCACGTCCACCCGGAGAACGGGGAGCGCTCGCTGATCGTCGGCCACT
TCATCCAGCGGATCCTGGGCCTGACCACCGCGGATTCGCAGCATCTCCTGGCGATCTTCCACGACCACGCGACCCGGCCC
GAGAACACCGTGCGCTGGTCGTGGCGGACGGGCGACGTGGCGATCTGGGACAACCGCGCCACGGTCCACCGGGCGGTGGA
CGATTACGGCGAGGCGCCCCGCGTGGTCCGCCGCGTGACGATCCAGGGCGTCGCGCCGGTGAGCGTCGACGGCCGCACCA
GCCGGGCGCGGGGGACGCAGGCGCGCGAGGCCGCGTGA

Upstream 100 bases:

>100_bases
GTGCCGGAGCGGAGCTTGTCCGAAGTTCTCCCGGTCCGAACACCTCGGTTCATCGCGCGATCCGCGCATCCCGTCGCCGC
CCTGCCTGGGAAACTTTTCG

Downstream 100 bases:

>100_bases
CCCGCGACGGGCCGCGCGGCGGCCGTGCCGGCTGCCGTCACGTCGCCCGCTGGCCGCGCGCCACCGCCCGGGCGAGGCTC
GCGGTCACCTGCGCCTCCGA

Product: taurine dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAVPQPLHASVPALDIRRVAGRLGAEIRGLALSGDLDDGTVAAIRQALNTHKVVFFRDQDLDEAEQEAFGRRLGDLVAH
PTVPSLAGTAGVLDIDGSRGERASSWHTDVTFVPAYPALSILRAVTLPPYGGDTLWANTAAAYADLPEPLRDLADKLWAL
HSNVYDYVGGRVNVSEAGRRRYDEVFTKTVFETEHPLVHVHPENGERSLIVGHFIQRILGLTTADSQHLLAIFHDHATRP
ENTVRWSWRTGDVAIWDNRATVHRAVDDYGEAPRVVRRVTIQGVAPVSVDGRTSRARGTQAREAA

Sequences:

>Translated_305_residues
MSAVPQPLHASVPALDIRRVAGRLGAEIRGLALSGDLDDGTVAAIRQALNTHKVVFFRDQDLDEAEQEAFGRRLGDLVAH
PTVPSLAGTAGVLDIDGSRGERASSWHTDVTFVPAYPALSILRAVTLPPYGGDTLWANTAAAYADLPEPLRDLADKLWAL
HSNVYDYVGGRVNVSEAGRRRYDEVFTKTVFETEHPLVHVHPENGERSLIVGHFIQRILGLTTADSQHLLAIFHDHATRP
ENTVRWSWRTGDVAIWDNRATVHRAVDDYGEAPRVVRRVTIQGVAPVSVDGRTSRARGTQAREAA
>Mature_304_residues
SAVPQPLHASVPALDIRRVAGRLGAEIRGLALSGDLDDGTVAAIRQALNTHKVVFFRDQDLDEAEQEAFGRRLGDLVAHP
TVPSLAGTAGVLDIDGSRGERASSWHTDVTFVPAYPALSILRAVTLPPYGGDTLWANTAAAYADLPEPLRDLADKLWALH
SNVYDYVGGRVNVSEAGRRRYDEVFTKTVFETEHPLVHVHPENGERSLIVGHFIQRILGLTTADSQHLLAIFHDHATRPE
NTVRWSWRTGDVAIWDNRATVHRAVDDYGEAPRVVRRVTIQGVAPVSVDGRTSRARGTQAREAA

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=276, Percent_Identity=37.3188405797101, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322971, Length=298, Percent_Identity=29.5302013422819, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 33389; Mature: 33258

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPQPLHASVPALDIRRVAGRLGAEIRGLALSGDLDDGTVAAIRQALNTHKVVFFRDQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
DLDEAEQEAFGRRLGDLVAHPTVPSLAGTAGVLDIDGSRGERASSWHTDVTFVPAYPALS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHH
ILRAVTLPPYGGDTLWANTAAAYADLPEPLRDLADKLWALHSNVYDYVGGRVNVSEAGRR
HHHHHCCCCCCCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
RYDEVFTKTVFETEHPLVHVHPENGERSLIVGHFIQRILGLTTADSQHLLAIFHDHATRP
HHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
ENTVRWSWRTGDVAIWDNRATVHRAVDDYGEAPRVVRRVTIQGVAPVSVDGRTSRARGTQ
CCCEEEEEECCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCC
AREAA
HHCCC
>Mature Secondary Structure 
SAVPQPLHASVPALDIRRVAGRLGAEIRGLALSGDLDDGTVAAIRQALNTHKVVFFRDQ
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
DLDEAEQEAFGRRLGDLVAHPTVPSLAGTAGVLDIDGSRGERASSWHTDVTFVPAYPALS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCHHHHH
ILRAVTLPPYGGDTLWANTAAAYADLPEPLRDLADKLWALHSNVYDYVGGRVNVSEAGRR
HHHHHCCCCCCCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
RYDEVFTKTVFETEHPLVHVHPENGERSLIVGHFIQRILGLTTADSQHLLAIFHDHATRP
HHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
ENTVRWSWRTGDVAIWDNRATVHRAVDDYGEAPRVVRRVTIQGVAPVSVDGRTSRARGTQ
CCCEEEEEECCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCC
AREAA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]