Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 170751328

GI number: 170751328

Start: 5266117

End: 5266950

Strand: Reverse

Name: proC [H]

Synonym: Mrad2831_4946

Alternate gene names: 170751328

Gene position: 5266950-5266117 (Counterclockwise)

Preceding gene: 170751329

Following gene: 170751327

Centisome position: 86.66

GC content: 78.66

Gene sequence:

>834_bases
GTGACCGGGCCGGGCGCCTCGACGGCGCGGATGCCCGCCTCCCTGGTCCTGGCCGGGGCCGGCAAGATGGGCGGCGCGAT
GCTGGCGGGCTGGCTGGACGCGGGCCTCGACCCGCGCCGCACCACCATCGTCGACCCGGTGCCCGCGCGCCCGATCGTGG
ATCTCTGCACCGAGCGGGGCATCGCCCTGAACCCGACCGACCCCGAGCCCGGCGCCGTCCTGGTCCTGGGGATCAAGCCG
CAGGGCCTGGACACGGCGGCCCCCGGGCTCGACCGGCTCATCGGCCGCGACACGCTCCTCGTCTCGATCCTGGCCGGCAA
GACCGTCGCGGATCTCCGCGGCCGGCTGCCGCGGGCGCGCGCGATCGTCCGGGCGATGCCCAACCTCCCGGCGAGCATCG
GCCGGGGCGCCACCGGCGCCTGCGCGAGCCCCGAGGTCACCCCGGCGCAGCGGGCGGCCGCCGAGGCGCTGCTCGCCGCG
AACGGCGCGGTGGCGTGGCTCACCGACGAGGCGCAGATCGACGCGGTGACGGCGGTCTCGGGCTCCGGACCGGCCTACGT
CTTCCTGCTGGCCGAGACCCTGGCGGAGGCCGGCATCGCGGCCGGCCTGGAACCTGAGGTCGCCCGCAGCCTCGCCCGGG
CGACCGTGGCGGGGGCCGGCGCGCTCCTCGATGCCAGCCCGGCCGAGGCGGCGGAGTTGCGCCGCAACGTCACGTCGCCC
GGCGGCACGACCGCGGCGGCCCTCGAGGTGCTGATGCGGCCGGACGGCCTCGGCGCGCTGATGCGGGAGGCCGTGGCCGC
GGCCCGTCGGCGGGCGGGGGAACTGTCCGGCTGA

Upstream 100 bases:

>100_bases
CCTGCGAGCGCTACTTCCAGGCGTTCCAGTTCGTCCTCTGGGCCGGCAAGAGCGCCCGCGAGGCCCTCGACGCCGTCCTG
TTCGAGACCGAAGGCGAGGC

Downstream 100 bases:

>100_bases
CATCGGGCTGATGGCGGGGGCTGACATCGGGCGGCGTCCGTGCGGCATGGCCGCGCGACGGACCTGCCCTTCGCGGCCCG
TCCGCCTACATGAGGCGACA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTGPGASTARMPASLVLAGAGKMGGAMLAGWLDAGLDPRRTTIVDPVPARPIVDLCTERGIALNPTDPEPGAVLVLGIKP
QGLDTAAPGLDRLIGRDTLLVSILAGKTVADLRGRLPRARAIVRAMPNLPASIGRGATGACASPEVTPAQRAAAEALLAA
NGAVAWLTDEAQIDAVTAVSGSGPAYVFLLAETLAEAGIAAGLEPEVARSLARATVAGAGALLDASPAEAAELRRNVTSP
GGTTAAALEVLMRPDGLGALMREAVAAARRRAGELSG

Sequences:

>Translated_277_residues
MTGPGASTARMPASLVLAGAGKMGGAMLAGWLDAGLDPRRTTIVDPVPARPIVDLCTERGIALNPTDPEPGAVLVLGIKP
QGLDTAAPGLDRLIGRDTLLVSILAGKTVADLRGRLPRARAIVRAMPNLPASIGRGATGACASPEVTPAQRAAAEALLAA
NGAVAWLTDEAQIDAVTAVSGSGPAYVFLLAETLAEAGIAAGLEPEVARSLARATVAGAGALLDASPAEAAELRRNVTSP
GGTTAAALEVLMRPDGLGALMREAVAAARRRAGELSG
>Mature_276_residues
TGPGASTARMPASLVLAGAGKMGGAMLAGWLDAGLDPRRTTIVDPVPARPIVDLCTERGIALNPTDPEPGAVLVLGIKPQ
GLDTAAPGLDRLIGRDTLLVSILAGKTVADLRGRLPRARAIVRAMPNLPASIGRGATGACASPEVTPAQRAAAEALLAAN
GAVAWLTDEAQIDAVTAVSGSGPAYVFLLAETLAEAGIAAGLEPEVARSLARATVAGAGALLDASPAEAAELRRNVTSPG
GTTAAALEVLMRPDGLGALMREAVAAARRRAGELSG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=31.6546762589928, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=31.6363636363636, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=29.811320754717, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=30.6273062730627, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=30.3703703703704, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=31.1787072243346, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=28.4697508896797, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=28.9198606271777, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.0943396226415, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=39.3063583815029, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24648116, Length=229, Percent_Identity=28.82096069869, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27646; Mature: 27515

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPGASTARMPASLVLAGAGKMGGAMLAGWLDAGLDPRRTTIVDPVPARPIVDLCTERG
CCCCCCCCHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHCCC
IALNPTDPEPGAVLVLGIKPQGLDTAAPGLDRLIGRDTLLVSILAGKTVADLRGRLPRAR
CEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHCCHHHHHHCCCHHHH
AIVRAMPNLPASIGRGATGACASPEVTPAQRAAAEALLAANGAVAWLTDEAQIDAVTAVS
HHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEC
GSGPAYVFLLAETLAEAGIAAGLEPEVARSLARATVAGAGALLDASPAEAAELRRNVTSP
CCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC
GGTTAAALEVLMRPDGLGALMREAVAAARRRAGELSG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGPGASTARMPASLVLAGAGKMGGAMLAGWLDAGLDPRRTTIVDPVPARPIVDLCTERG
CCCCCCCHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHCCC
IALNPTDPEPGAVLVLGIKPQGLDTAAPGLDRLIGRDTLLVSILAGKTVADLRGRLPRAR
CEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHCCHHHHHHCCCHHHH
AIVRAMPNLPASIGRGATGACASPEVTPAQRAAAEALLAANGAVAWLTDEAQIDAVTAVS
HHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEC
GSGPAYVFLLAETLAEAGIAAGLEPEVARSLARATVAGAGALLDASPAEAAELRRNVTSP
CCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC
GGTTAAALEVLMRPDGLGALMREAVAAARRRAGELSG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]