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The map label for this gene is gltT [H]

Identifier: 170748666

GI number: 170748666

Start: 2381447

End: 2382727

Strand: Reverse

Name: gltT [H]

Synonym: Mrad2831_2248

Alternate gene names: 170748666

Gene position: 2382727-2381447 (Counterclockwise)

Preceding gene: 170748677

Following gene: 170748665

Centisome position: 39.2

GC content: 66.43

Gene sequence:

>1281_bases
ATGGCAGGGTCGCGACTCACGACGATGATCTTCGTCGGCATGCTCCTCGGAATCGCCGTCGGCTACGCCTGCAGCATCAC
CTGGCCCGACCCGCAGACCGCCAAGGAGATCGCCGGCTACATCGCGCTGGTCTCCGACGTGTTCCTGCGGCTGATCAAGA
TGATCATCGCGCCGCTGGTCTTCTCCACGCTGGTGGTCGGCATCGCGCATCTCGGGGACACGGCGTCGGTCGGCCGGGTC
GGCGGCAAGGCGCTGCTCTGGTTCGTCGGCGCCTCGTTCTGCTCGCTGATGCTCGGCCTCATCATGGTCAACCTGATGCA
GCCCGGCCACAACCTGAACCTGCCGCTGCCCGATGCCGGGGCCGGCACCGGGCTCAAGGCGGCCTCGCTCTCGCTCAAGG
AGTTCGTGACGCACCTCGTGCCGAAGAGCGCCGTCGAGGCGATGGCCAACAACGAGATCCTGCAGATCGTGGTCTTCTCG
ATCTTCTTCGGCGTGGGCCTCGCCGCCCTCGGCGAGAAGGGGCGCCTGCTCGCGCAGGGTATCGAGGGCGTCGCCGACGT
GATGCTCAAGGTGACGGGCTACGTGATGATGTTCGCCCCCGTGGCGGTGTTCGCCGCCATCGCGGCGACCATCACCACGC
AGGGCATCGGCGTGCTGATCACCTACGGCAAGTTCCTCGTGGAGTTCTACATCGGCCTCGGCGTGCTCTGGGTGCTGCTG
ATGGGGGTCGGCTTCCTGATGCTCGGGGCCGGCGGCATCGCGCGGCTGTTCAACCTGATCAAGGAGCCCTTCGTCCTGGC
CTTCTCGACCGCGTCGAGCGAGGCGGCCTACCCGAAGATGCTGACGAACCTGGAGAAGTTCGGGGTGCCGAACCGCATCA
CGTCGTTCGTTCTGCCGATGGGCTACTCGTTCAACCTCGACGGCTCGATGATGTACTGCACCTTCGCGGTGATGTTCATC
GCGCAGGCCTACAACATCCCGCTGAGCTGGGGCCAGCAGCTCACGATGCTGCTCCTGCTGATGGTGACCTCGAAGGGCAT
GGCCGGCGTGCCGCGCGCCTCGCTGGTGGTGATCTCGGCGACGCTGTCGCACTTCAACATCCCGGAGGCCGGGCTGCTGC
TGATCATCGGGATCGACCAGTTCCTCGACATGGGCCGGTCGGCCACCAACGTGCTGGGCAACAGCGTCGCCACCGTGGCG
GTCGCCAAGTGGGAGGGCCAGCTCAGCACCACCGACCAGCGCCTCGACCATGTCGGCACGGTGGCCTCGCCCGCGGAGTA
G

Upstream 100 bases:

>100_bases
GTAACGCCCCCTGGTCGGGCTTGCGTGTGGCGCAGTTCCTGCGACACGTTAACGAATTGAAATGCTCGATCATCCCGGGC
CCGTGCGAGGAGCAGTACCG

Downstream 100 bases:

>100_bases
GGGCCGGTCCCGGGAAATCTGCGCGCGCCGGGATGGCGGGCGCAAGAAGGCCGCTCTCATGAGCGCTCTCACGGGTGCCC
GGAATCGCGGCGTGGCTTGT

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAGSRLTTMIFVGMLLGIAVGYACSITWPDPQTAKEIAGYIALVSDVFLRLIKMIIAPLVFSTLVVGIAHLGDTASVGRV
GGKALLWFVGASFCSLMLGLIMVNLMQPGHNLNLPLPDAGAGTGLKAASLSLKEFVTHLVPKSAVEAMANNEILQIVVFS
IFFGVGLAALGEKGRLLAQGIEGVADVMLKVTGYVMMFAPVAVFAAIAATITTQGIGVLITYGKFLVEFYIGLGVLWVLL
MGVGFLMLGAGGIARLFNLIKEPFVLAFSTASSEAAYPKMLTNLEKFGVPNRITSFVLPMGYSFNLDGSMMYCTFAVMFI
AQAYNIPLSWGQQLTMLLLLMVTSKGMAGVPRASLVVISATLSHFNIPEAGLLLIIGIDQFLDMGRSATNVLGNSVATVA
VAKWEGQLSTTDQRLDHVGTVASPAE

Sequences:

>Translated_426_residues
MAGSRLTTMIFVGMLLGIAVGYACSITWPDPQTAKEIAGYIALVSDVFLRLIKMIIAPLVFSTLVVGIAHLGDTASVGRV
GGKALLWFVGASFCSLMLGLIMVNLMQPGHNLNLPLPDAGAGTGLKAASLSLKEFVTHLVPKSAVEAMANNEILQIVVFS
IFFGVGLAALGEKGRLLAQGIEGVADVMLKVTGYVMMFAPVAVFAAIAATITTQGIGVLITYGKFLVEFYIGLGVLWVLL
MGVGFLMLGAGGIARLFNLIKEPFVLAFSTASSEAAYPKMLTNLEKFGVPNRITSFVLPMGYSFNLDGSMMYCTFAVMFI
AQAYNIPLSWGQQLTMLLLLMVTSKGMAGVPRASLVVISATLSHFNIPEAGLLLIIGIDQFLDMGRSATNVLGNSVATVA
VAKWEGQLSTTDQRLDHVGTVASPAE
>Mature_425_residues
AGSRLTTMIFVGMLLGIAVGYACSITWPDPQTAKEIAGYIALVSDVFLRLIKMIIAPLVFSTLVVGIAHLGDTASVGRVG
GKALLWFVGASFCSLMLGLIMVNLMQPGHNLNLPLPDAGAGTGLKAASLSLKEFVTHLVPKSAVEAMANNEILQIVVFSI
FFGVGLAALGEKGRLLAQGIEGVADVMLKVTGYVMMFAPVAVFAAIAATITTQGIGVLITYGKFLVEFYIGLGVLWVLLM
GVGFLMLGAGGIARLFNLIKEPFVLAFSTASSEAAYPKMLTNLEKFGVPNRITSFVLPMGYSFNLDGSMMYCTFAVMFIA
QAYNIPLSWGQQLTMLLLLMVTSKGMAGVPRASLVVISATLSHFNIPEAGLLLIIGIDQFLDMGRSATNVLGNSVATVAV
AKWEGQLSTTDQRLDHVGTVASPAE

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=27.0880361173815, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI21314632, Length=397, Percent_Identity=27.2040302267003, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40254478, Length=467, Percent_Identity=25.6959314775161, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI66773030, Length=415, Percent_Identity=24.3373493975904, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI4827012, Length=272, Percent_Identity=30.5147058823529, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223468564, Length=248, Percent_Identity=29.0322580645161, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223468566, Length=257, Percent_Identity=29.1828793774319, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI5032093, Length=376, Percent_Identity=26.8617021276596, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI262359914, Length=391, Percent_Identity=24.8081841432225, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194239697, Length=251, Percent_Identity=28.6852589641434, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI301601644, Length=165, Percent_Identity=33.9393939393939, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1789947, Length=425, Percent_Identity=37.6470588235294, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1790514, Length=372, Percent_Identity=39.7849462365591, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1788024, Length=420, Percent_Identity=24.047619047619, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996953, Length=472, Percent_Identity=25.635593220339, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71983106, Length=430, Percent_Identity=25.5813953488372, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983099, Length=430, Percent_Identity=25.5813953488372, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537407, Length=420, Percent_Identity=24.7619047619048, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=453, Percent_Identity=23.841059602649, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=432, Percent_Identity=25.2314814814815, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=24.8138957816377, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583025, Length=465, Percent_Identity=25.3763440860215, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17137668, Length=465, Percent_Identity=25.3763440860215, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24583023, Length=465, Percent_Identity=25.3763440860215, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI281360483, Length=414, Percent_Identity=26.5700483091787, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=414, Percent_Identity=26.5700483091787, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360481, Length=414, Percent_Identity=26.5700483091787, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45016; Mature: 44885

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure 
AGSRLTTMIFVGMLLGIAVGYACSITWPDPQTAKEIAGYIALVSDVFLRLIKMIIAPLV
CCCHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTLVVGIAHLGDTASVGRVGGKALLWFVGASFCSLMLGLIMVNLMQPGHNLNLPLPDAG
HHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGTGLKAASLSLKEFVTHLVPKSAVEAMANNEILQIVVFSIFFGVGLAALGEKGRLLAQG
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IEGVADVMLKVTGYVMMFAPVAVFAAIAATITTQGIGVLITYGKFLVEFYIGLGVLWVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MGVGFLMLGAGGIARLFNLIKEPFVLAFSTASSEAAYPKMLTNLEKFGVPNRITSFVLPM
HHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCC
GYSFNLDGSMMYCTFAVMFIAQAYNIPLSWGQQLTMLLLLMVTSKGMAGVPRASLVVISA
CCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEH
TLSHFNIPEAGLLLIIGIDQFLDMGRSATNVLGNSVATVAVAKWEGQLSTTDQRLDHVGT
HHHHCCCCCCCEEEEEEHHHHHHCCCHHHHHHCCCHHHEEEEECCCCCCCHHHHHHHHCC
VASPAE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]