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The map label for this gene is metC [H]

Identifier: 170748583

GI number: 170748583

Start: 2307380

End: 2308570

Strand: Reverse

Name: metC [H]

Synonym: Mrad2831_2165

Alternate gene names: 170748583

Gene position: 2308570-2307380 (Counterclockwise)

Preceding gene: 170748584

Following gene: 170748582

Centisome position: 37.98

GC content: 71.96

Gene sequence:

>1191_bases
ATGTCCCTGAAGCCCTCGCCCGACGCCAAGCAGACCTTCGCGCCCGCGACGCGCCTCGTCCACGCGGGCCGTGACCCGGG
CGAGCAGCACGGCTTCGTGAACACGCCGATCTACCGCGGATCCACGGTCCTCTACCCGACCTACGACGCGATCAAGAACC
GGCGCGGCCGCTACAATTACGGGACCTCGGCGACACCGACGATGGACTCGCTGACGGAGGCGTGGACGGAACTCGCCGGC
GCCGCCGGAACCGTCGTGACGCCCTCCGGGCTCGCGGCGCTCACCGTCGCGCTGATGGCCGCGGTCTCGGCGGGCGACCA
CCTCCTCGTCACCGATTCCGCCTATCGGCCGACCCGCCAGTTCTGCGACGGCGTGCTGGCGCGCTACGGCGTCGAGGTGA
CCTACTACGACCCGACCATCGGGGCCGGCATCGCGGAACTGATGCGCCCGAATACCCGGGCCGTGCTGGTCGAGGCGCCC
GGCTCGCAGAGCTTCGAGATGCAGGATATCCCGGCCATCGCCGAGGTCGCGCACGCACACGACGCCTGCGTGATCATGGA
CAACACCTGGGCGACGCCGCTGCTGTTCCCGCCGCACGCGCGCGGCGTCGACATCGCGGTCGAGGCCGGCACCAAGTACC
TCAGCGGCGGCTCGGACCTGCTGATCGGCCTGACCTCCGCGAACGCGCGCTACTACCCGGCCGTGCGCCGCACCTTCGAC
CATTTCGCCATGTGCGCCGGCGCCGAGGACATCTTCCTGGCGCTGCGCGGCCTGCGCACCATGTCCTTGCGGCTGCGCGA
GCACGGCCGCGCCGGACTGGAGATGGCCCGGTGGTTCCAGGCGCGGCCCGAGGTGCTGCGGGTGCTCCATCCCGGCCTGC
CCGAGGATCCCGGCCACGCGATCTGGAAGCGCGACTTCGCGGGCGCGTCGGGCCTGTTCGGGGTGATCCTGAAGCCGGTG
CCCGAGGCCGCGGTGGCCGCCATGCTGGACGGGCTGCAGCTCTTCGGGATGGGCTTCTCGTGGGGCGGCTTCGAGAGCCT
CGTGATCCCGTTCGACTGCGCCGGCTACCGGACCGCGACCCGGTGGGCTCCCGGCGGACCGGCGCTCCGCTTCCACATCG
GGCTTGAGGACACCGCCGACCTCAAGGCCGACCTCGACGCCGGCTTCGCGCGCCTCCGGGCGGCGTCGTAG

Upstream 100 bases:

>100_bases
AAACCCGGAGGCCCGGCACCGCGAGCCCGCGCGTCCGGCTTGACCTTGCCGGGCGCGGCGCGCTTCGTGCGGTGCACCGC
AACGCGATCTCCGAGCCTCG

Downstream 100 bases:

>100_bases
GGCGGGGCCGGGCGCCGCGCTACGACGCTGCCCTTCCCGGACAGGTGAGGACCGGCGAACCTTGACCCGGACCGCGCGCC
GCGGGCGGTGCCGCATCCGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSLKPSPDAKQTFAPATRLVHAGRDPGEQHGFVNTPIYRGSTVLYPTYDAIKNRRGRYNYGTSATPTMDSLTEAWTELAG
AAGTVVTPSGLAALTVALMAAVSAGDHLLVTDSAYRPTRQFCDGVLARYGVEVTYYDPTIGAGIAELMRPNTRAVLVEAP
GSQSFEMQDIPAIAEVAHAHDACVIMDNTWATPLLFPPHARGVDIAVEAGTKYLSGGSDLLIGLTSANARYYPAVRRTFD
HFAMCAGAEDIFLALRGLRTMSLRLREHGRAGLEMARWFQARPEVLRVLHPGLPEDPGHAIWKRDFAGASGLFGVILKPV
PEAAVAAMLDGLQLFGMGFSWGGFESLVIPFDCAGYRTATRWAPGGPALRFHIGLEDTADLKADLDAGFARLRAAS

Sequences:

>Translated_396_residues
MSLKPSPDAKQTFAPATRLVHAGRDPGEQHGFVNTPIYRGSTVLYPTYDAIKNRRGRYNYGTSATPTMDSLTEAWTELAG
AAGTVVTPSGLAALTVALMAAVSAGDHLLVTDSAYRPTRQFCDGVLARYGVEVTYYDPTIGAGIAELMRPNTRAVLVEAP
GSQSFEMQDIPAIAEVAHAHDACVIMDNTWATPLLFPPHARGVDIAVEAGTKYLSGGSDLLIGLTSANARYYPAVRRTFD
HFAMCAGAEDIFLALRGLRTMSLRLREHGRAGLEMARWFQARPEVLRVLHPGLPEDPGHAIWKRDFAGASGLFGVILKPV
PEAAVAAMLDGLQLFGMGFSWGGFESLVIPFDCAGYRTATRWAPGGPALRFHIGLEDTADLKADLDAGFARLRAAS
>Mature_395_residues
SLKPSPDAKQTFAPATRLVHAGRDPGEQHGFVNTPIYRGSTVLYPTYDAIKNRRGRYNYGTSATPTMDSLTEAWTELAGA
AGTVVTPSGLAALTVALMAAVSAGDHLLVTDSAYRPTRQFCDGVLARYGVEVTYYDPTIGAGIAELMRPNTRAVLVEAPG
SQSFEMQDIPAIAEVAHAHDACVIMDNTWATPLLFPPHARGVDIAVEAGTKYLSGGSDLLIGLTSANARYYPAVRRTFDH
FAMCAGAEDIFLALRGLRTMSLRLREHGRAGLEMARWFQARPEVLRVLHPGLPEDPGHAIWKRDFAGASGLFGVILKPVP
EAAVAAMLDGLQLFGMGFSWGGFESLVIPFDCAGYRTATRWAPGGPALRFHIGLEDTADLKADLDAGFARLRAAS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=346, Percent_Identity=30.0578034682081, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI299473759, Length=346, Percent_Identity=27.1676300578035, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI25453487, Length=345, Percent_Identity=27.2463768115942, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789383, Length=387, Percent_Identity=41.8604651162791, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1790375, Length=387, Percent_Identity=31.266149870801, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=27.4666666666667, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=333, Percent_Identity=31.2312312312312, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17538055, Length=339, Percent_Identity=29.7935103244838, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=332, Percent_Identity=52.4096385542169, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319307, Length=390, Percent_Identity=27.9487179487179, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323333, Length=437, Percent_Identity=24.7139588100687, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=25.062656641604, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=30.8093994778068, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42520; Mature: 42389

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKPSPDAKQTFAPATRLVHAGRDPGEQHGFVNTPIYRGSTVLYPTYDAIKNRRGRYNY
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCEEEEECHHHHHCCCCCCCC
GTSATPTMDSLTEAWTELAGAAGTVVTPSGLAALTVALMAAVSAGDHLLVTDSAYRPTRQ
CCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
FCDGVLARYGVEVTYYDPTIGAGIAELMRPNTRAVLVEAPGSQSFEMQDIPAIAEVAHAH
HHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCC
DACVIMDNTWATPLLFPPHARGVDIAVEAGTKYLSGGSDLLIGLTSANARYYPAVRRTFD
CEEEEEECCCCCCEECCCCCCCEEEEEECCCEEECCCCEEEEEEECCCCEECHHHHHHHH
HFAMCAGAEDIFLALRGLRTMSLRLREHGRAGLEMARWFQARPEVLRVLHPGLPEDPGHA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
IWKRDFAGASGLFGVILKPVPEAAVAAMLDGLQLFGMGFSWGGFESLVIPFDCAGYRTAT
HHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCHHHEECCCCCCCCCEEEEEECCCCCCCCC
RWAPGGPALRFHIGLEDTADLKADLDAGFARLRAAS
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLKPSPDAKQTFAPATRLVHAGRDPGEQHGFVNTPIYRGSTVLYPTYDAIKNRRGRYNY
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCEEEEECHHHHHCCCCCCCC
GTSATPTMDSLTEAWTELAGAAGTVVTPSGLAALTVALMAAVSAGDHLLVTDSAYRPTRQ
CCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
FCDGVLARYGVEVTYYDPTIGAGIAELMRPNTRAVLVEAPGSQSFEMQDIPAIAEVAHAH
HHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCC
DACVIMDNTWATPLLFPPHARGVDIAVEAGTKYLSGGSDLLIGLTSANARYYPAVRRTFD
CEEEEEECCCCCCEECCCCCCCEEEEEECCCEEECCCCEEEEEEECCCCEECHHHHHHHH
HFAMCAGAEDIFLALRGLRTMSLRLREHGRAGLEMARWFQARPEVLRVLHPGLPEDPGHA
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
IWKRDFAGASGLFGVILKPVPEAAVAAMLDGLQLFGMGFSWGGFESLVIPFDCAGYRTAT
HHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCHHHEECCCCCCCCCEEEEEECCCCCCCCC
RWAPGGPALRFHIGLEDTADLKADLDAGFARLRAAS
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]