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The map label for this gene is luxQ [H]

Identifier: 170748577

GI number: 170748577

Start: 2300259

End: 2302649

Strand: Reverse

Name: luxQ [H]

Synonym: Mrad2831_2159

Alternate gene names: 170748577

Gene position: 2302649-2300259 (Counterclockwise)

Preceding gene: 170748578

Following gene: 170748576

Centisome position: 37.89

GC content: 72.23

Gene sequence:

>2391_bases
ATGAGCGAGACTGAGAGCGGCCCAGGATCCGTCACGGATGCCGATTACCGCAACCTCGCCGAGACGCTGCCGCAGCTCGC
CTGGATCGCCGAGGCCGACGGCACGATCATCTGGTACAATCAGCGCTGGTACGACTACACCGGCACCTCCCTCGACGAGA
TGCGGGGCTGGGGCTGGCGCACGGTCCATCACCCGGACCACGTCGCGGCCGTGACCGAGCGCTACCGCGCCGCGATCACG
CTGGGCCGGTCCTGGGAGGACACGTTCCCGCTGCGCGGCCGCGACGGGAGCTACCGCTGGTTCCTGTCGAAGGCGCTGCC
CCACCGGGACGAGTCCGGGCGGATCCTGCGCTGGTACGGGACCAACACCGACATCACCGGCCGCCGCGCGGTCGAGGAGC
GCCTGCGCCACTCCGAGCAGCGCTTCCGGGCGCTGGTGGACGCCTCGGCGGCGGTGATCTGGAACACCGACGCGGCGGGC
GAGCTGATGCCGCCGCAGGTCCGGTGGAGCACCTATACCGGGCAGACCGAGGAGGCCTACCAGGGCTGGGGCTGGCTGGA
CGCCGTCCATCCCGACGACCGGGGCCACGCGGCCGACGCCTGGGCGGCCTGCGTCGAGGCGCGCGCGACCTACGAGGTCG
AGTACAGGCTGCGCCGGTACGACGGGGTCTGGCGCGCCATGGAGGTGCGCGGCGTGCCGGTCCTCGCCGAGGACGGCTCC
CTGCGGGAATGGGTCGGCACCTGCGTCGACGTCACCGAGCGGAAGGAGGCCGAGGAGGCGGTGGAGCGCGCCCGGCAGGC
CGCCGAGGCGGCCAACCGGGCGAAGAGCCAGTTCATCGCCAACATGAGCCACGAGCTGCGCACGCCGCTCTCGGCGGTGA
TCGGCTACTCCGAGATGCTCGGCGAGGAGCTGGAGGATATCGGCCAGGCCGCCCTCCTGCCCGACCTGCGCAAGATCGAG
GCGGCCGCCCGCCACCTGCTCTCGCTGATCAACGACGTGCTCGACATCTCGAAGATCGAGGCGGGCCGCATGACCGCCTC
GGCCGAGACCTTCACGGTGTCGGACCTGCTCCGGGACGTCTCCGACTCCACCGGCTCCCTGGTTGAGAAGAAGGGCAACC
GCTTCGTCCTGGACACCGGCGCGGCCGGGACGGCCGACCTGGGGTCCATGCACCAGGACCAGACCAAGATCCGCCAGTGC
CTGCTGAACCTGATCGGCAACGCCGCGAAGTTCACCGAGCGGGGAACGATCACCCTGACGGTGCGGCGGCACCGGGAGGA
GGGAGCCGACTGGCTGTCCTTCGCGGTCGCCGACACCGGCATCGGCCTGACCGAGGAGCAGATCGGGCGCCTGTTCGAGC
GCTTCGTCCAGGCCGACGATTCGACGACCCGGCAGTTCGGCGGCACGGGCCTCGGGCTCGCCATCACCCGCGCGTTCTGC
CGGACGATGGGCGGCGACATCGGCGTCGCCAGCACGCCGGGCGCGGGCGCGACCTTCACGATCCGCCTGCCCGCCACCCT
GCGGCCCGAGGACGCGCCGCCCTCCGAGGCCGAGGCCCACACGCCGGTGGAGCCGCACGAGCAGCACGAGACGGTGCTGC
TGGTCGACGACGACCCGGCCGCCCGGGAATTGCTCCAGCGCTTCCTGGAACGCGAGGGCTTCCACGTCCGCAGCGCCAAC
GACGGCCGCGCCGGCCTGACGCTCGCCCGGGCCCTGAAGCCGCGCGCGATCCTGCTCGACGTCGAGATGCCGCGCATGGA
CGGCTGGGCGGTCCTGCACGCGGTGCGCAACGACCCCGACCTCGCCGGTACGCCGGTGATCATGACCTCGGTCGTGGCCG
AGCAGGGGCTCGGCCAGGCGCTCGGCGCCACCGACTACTTCGTCAAGCCGATCGACTGGGACCGGCTCAAGGGCCTGATG
GAGCGCTACCGGCCCGAGGCGCCGGAGGATGCCCGCGTCCTCGTGGTCGACGACGACGCGGATGCCCGCGAGCGCCTGCG
CCGGTCGCTCGGCCGCGAGGGCTGGACCGTCGACGAGGCGGAGAACGGCCGGATCGCCCTGGAGCGGGTCAGCCAGGCGC
GGCCGAGCCTGATCCTGCTCGACCTGATGATGCCCGAGATGGACGGGTTCGGCTTCCTCCGGGCCTTGCGGGCGCGGCCC
GACGGCGACGTGCCCGTGGTGGTGCTCACCGCCAAGGAGGTCACGGCGGCCGAGAAGGAGAGCCTGAACCGGCAGGCCGA
CCGGGTGATCGCCAAGGGCTCCATGAGCCTCGCGGAGATCGGCCGGCAACTGCGCGTCCTCTACGCGCGTTCGGCGACCG
AGCCGGTGCCGGGGCAGCTCCAGGGGTTGCTCGATCGGCTCGCCGAGAAGGACGCGGGAGAACCACGATGA

Upstream 100 bases:

>100_bases
CCGGCCCCCGCGGCCCCGCGGTCGGATCCCGACGCGATGCGTGTATAAGGAGTACGGGTATAAGCCGCCGCGGGGCGGGT
GACGGGACAGCGTCGGGTCG

Downstream 100 bases:

>100_bases
GTGCCGACGGGATCGATCCGGAGAAGGCGGTGGCCATCCGGCTGCGGGCGCGGCTCGCGGTGGTGGAGCGGGCGGCGTGG
TTCGGCTTCGTCCACGCGAT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 795

Protein sequence:

>796_residues
MSETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDYTGTSLDEMRGWGWRTVHHPDHVAAVTERYRAAIT
LGRSWEDTFPLRGRDGSYRWFLSKALPHRDESGRILRWYGTNTDITGRRAVEERLRHSEQRFRALVDASAAVIWNTDAAG
ELMPPQVRWSTYTGQTEEAYQGWGWLDAVHPDDRGHAADAWAACVEARATYEVEYRLRRYDGVWRAMEVRGVPVLAEDGS
LREWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIE
AAARHLLSLINDVLDISKIEAGRMTASAETFTVSDLLRDVSDSTGSLVEKKGNRFVLDTGAAGTADLGSMHQDQTKIRQC
LLNLIGNAAKFTERGTITLTVRRHREEGADWLSFAVADTGIGLTEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
RTMGGDIGVASTPGAGATFTIRLPATLRPEDAPPSEAEAHTPVEPHEQHETVLLVDDDPAARELLQRFLEREGFHVRSAN
DGRAGLTLARALKPRAILLDVEMPRMDGWAVLHAVRNDPDLAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLM
ERYRPEAPEDARVLVVDDDADARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRARP
DGDVPVVVLTAKEVTAAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSATEPVPGQLQGLLDRLAEKDAGEPR

Sequences:

>Translated_796_residues
MSETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDYTGTSLDEMRGWGWRTVHHPDHVAAVTERYRAAIT
LGRSWEDTFPLRGRDGSYRWFLSKALPHRDESGRILRWYGTNTDITGRRAVEERLRHSEQRFRALVDASAAVIWNTDAAG
ELMPPQVRWSTYTGQTEEAYQGWGWLDAVHPDDRGHAADAWAACVEARATYEVEYRLRRYDGVWRAMEVRGVPVLAEDGS
LREWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIE
AAARHLLSLINDVLDISKIEAGRMTASAETFTVSDLLRDVSDSTGSLVEKKGNRFVLDTGAAGTADLGSMHQDQTKIRQC
LLNLIGNAAKFTERGTITLTVRRHREEGADWLSFAVADTGIGLTEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
RTMGGDIGVASTPGAGATFTIRLPATLRPEDAPPSEAEAHTPVEPHEQHETVLLVDDDPAARELLQRFLEREGFHVRSAN
DGRAGLTLARALKPRAILLDVEMPRMDGWAVLHAVRNDPDLAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLM
ERYRPEAPEDARVLVVDDDADARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRARP
DGDVPVVVLTAKEVTAAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSATEPVPGQLQGLLDRLAEKDAGEPR
>Mature_795_residues
SETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDYTGTSLDEMRGWGWRTVHHPDHVAAVTERYRAAITL
GRSWEDTFPLRGRDGSYRWFLSKALPHRDESGRILRWYGTNTDITGRRAVEERLRHSEQRFRALVDASAAVIWNTDAAGE
LMPPQVRWSTYTGQTEEAYQGWGWLDAVHPDDRGHAADAWAACVEARATYEVEYRLRRYDGVWRAMEVRGVPVLAEDGSL
REWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIEA
AARHLLSLINDVLDISKIEAGRMTASAETFTVSDLLRDVSDSTGSLVEKKGNRFVLDTGAAGTADLGSMHQDQTKIRQCL
LNLIGNAAKFTERGTITLTVRRHREEGADWLSFAVADTGIGLTEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFCR
TMGGDIGVASTPGAGATFTIRLPATLRPEDAPPSEAEAHTPVEPHEQHETVLLVDDDPAARELLQRFLEREGFHVRSAND
GRAGLTLARALKPRAILLDVEMPRMDGWAVLHAVRNDPDLAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLME
RYRPEAPEDARVLVVDDDADARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRARPD
GDVPVVVLTAKEVTAAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSATEPVPGQLQGLLDRLAEKDAGEPR

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=527, Percent_Identity=28.4629981024668, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI145693157, Length=539, Percent_Identity=30.2411873840445, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1788713, Length=397, Percent_Identity=30.9823677581864, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1789149, Length=252, Percent_Identity=38.8888888888889, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI87081816, Length=342, Percent_Identity=34.7953216374269, Blast_Score=152, Evalue=1e-37,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=35.1239669421488, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786912, Length=298, Percent_Identity=27.1812080536913, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=27.7153558052434, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=28.75, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=28.8702928870293, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=114, Percent_Identity=36.8421052631579, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=25.9109311740891, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=212, Percent_Identity=28.7735849056604, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788279, Length=312, Percent_Identity=21.7948717948718, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88278; Mature: 88147

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDYTGTSLDEMRGWGWR
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCEEECCCCCCHHHHCCCCCE
TVHHPDHVAAVTERYRAAITLGRSWEDTFPLRGRDGSYRWFLSKALPHRDESGRILRWYG
ECCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCEEEEEC
TNTDITGRRAVEERLRHSEQRFRALVDASAAVIWNTDAAGELMPPQVRWSTYTGQTEEAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCHHHH
QGWGWLDAVHPDDRGHAADAWAACVEARATYEVEYRLRRYDGVWRAMEVRGVPVLAEDGS
CCCCEEECCCCCCCCCHHHHHHHHHHHHCEEEEHHHHHHHCCHHHHHEECCCEEEECCCC
LREWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
GEELEDIGQAALLPDLRKIEAAARHLLSLINDVLDISKIEAGRMTASAETFTVSDLLRDV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SDSTGSLVEKKGNRFVLDTGAAGTADLGSMHQDQTKIRQCLLNLIGNAAKFTERGTITLT
CCCHHHHHHHCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEE
VRRHREEGADWLSFAVADTGIGLTEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
EEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
RTMGGDIGVASTPGAGATFTIRLPATLRPEDAPPSEAEAHTPVEPHEQHETVLLVDDDPA
HHCCCCCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
ARELLQRFLEREGFHVRSANDGRAGLTLARALKPRAILLDVEMPRMDGWAVLHAVRNDPD
HHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCC
LAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLMERYRPEAPEDARVLVVDDDA
CCCCHHHHHHHHHHHCCCHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
DARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRARP
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHHCCC
DGDVPVVVLTAKEVTAAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSATEPVPGQL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
QGLLDRLAEKDAGEPR
HHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDYTGTSLDEMRGWGWR
CCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCEEECCCCCCHHHHCCCCCE
TVHHPDHVAAVTERYRAAITLGRSWEDTFPLRGRDGSYRWFLSKALPHRDESGRILRWYG
ECCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCCEEEEEC
TNTDITGRRAVEERLRHSEQRFRALVDASAAVIWNTDAAGELMPPQVRWSTYTGQTEEAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCHHHH
QGWGWLDAVHPDDRGHAADAWAACVEARATYEVEYRLRRYDGVWRAMEVRGVPVLAEDGS
CCCCEEECCCCCCCCCHHHHHHHHHHHHCEEEEHHHHHHHCCHHHHHEECCCEEEECCCC
LREWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
GEELEDIGQAALLPDLRKIEAAARHLLSLINDVLDISKIEAGRMTASAETFTVSDLLRDV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SDSTGSLVEKKGNRFVLDTGAAGTADLGSMHQDQTKIRQCLLNLIGNAAKFTERGTITLT
CCCHHHHHHHCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEE
VRRHREEGADWLSFAVADTGIGLTEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
EEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
RTMGGDIGVASTPGAGATFTIRLPATLRPEDAPPSEAEAHTPVEPHEQHETVLLVDDDPA
HHCCCCCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
ARELLQRFLEREGFHVRSANDGRAGLTLARALKPRAILLDVEMPRMDGWAVLHAVRNDPD
HHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCC
LAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLMERYRPEAPEDARVLVVDDDA
CCCCHHHHHHHHHHHCCCHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
DARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRARP
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHHCCC
DGDVPVVVLTAKEVTAAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSATEPVPGQL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
QGLLDRLAEKDAGEPR
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]