BacMap

Definition	Methylobacterium radiotolerans JCM 2831 chromosome, complete genome.
Accession	NC_010505
Length	6,077,833

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The map label for this gene is ppi [H]

Identifier: 170748565

GI number: 170748565

Start: 2288757

End: 2289215

Strand: Reverse

Name: ppi [H]

Synonym: Mrad2831_2147

Alternate gene names: 170748565

Gene position: 2289215-2288757 (Counterclockwise)

Preceding gene: 170748566

Following gene: 170748561

Centisome position: 37.66

GC content: 68.19

Gene sequence:

>459_bases
ATGGCCGACAACGAGACCATCGTGCTGGAGACCACCAAGGGCCGCGTCGTGATCGCGCTGCGCCCCGACCTCGCCCCGGG
CCATGTCGAGCGGATCAAGACGCTCGCCGCCCAGGGCTTCTACGACGGCGTGCCGTTCCACCGCGTGATCGACGGGTTCA
TGGCCCAGACGGGCGACCCGACGGGCACCGGCTCGGGCGGTTCGGACCTGCCGGACCTGAAGGCCGAGTTCAACGCCGAG
CCGCACGTGCGCGGCACCTGCTCCATGGCGCGGACGAACTTCCCGCACTCGGCGAACTCGCAGTTCTTCATCTGCTTCGA
CGATGCCCGCTTCCTCGACAAGCAGTACACGGTGTGGGGCAAGGTCGTGGAAGGCATGGACGTGGTCGACACGATCAACA
AGGGCGAGCCGCCGCGCTCGCCGGACAAGATCGTGAAGGCGACCGTCGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCGTCTACCGCCCGCCGGCCTGAGCGCCGGCGAACCCGACACGGGCGCTGGCCGGATCCGGCGCGCGCCGATACAGTTCC
CCCAACCGGAAGGAAAGACC

Downstream 100 bases:

>100_bases
GCCCGGATTAAGCCTCACGTCTGAAGCCATCTCTCGGTGGCTTCGGCGCCGCTGTCGTTGCGAGCGGAGCGAAGCCATCC
AGGGGGCACGACGACTTCCT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MADNETIVLETTKGRVVIALRPDLAPGHVERIKTLAAQGFYDGVPFHRVIDGFMAQTGDPTGTGSGGSDLPDLKAEFNAE
PHVRGTCSMARTNFPHSANSQFFICFDDARFLDKQYTVWGKVVEGMDVVDTINKGEPPRSPDKIVKATVAAA

Sequences:

>Translated_152_residues
MADNETIVLETTKGRVVIALRPDLAPGHVERIKTLAAQGFYDGVPFHRVIDGFMAQTGDPTGTGSGGSDLPDLKAEFNAE
PHVRGTCSMARTNFPHSANSQFFICFDDARFLDKQYTVWGKVVEGMDVVDTINKGEPPRSPDKIVKATVAAA
>Mature_151_residues
ADNETIVLETTKGRVVIALRPDLAPGHVERIKTLAAQGFYDGVPFHRVIDGFMAQTGDPTGTGSGGSDLPDLKAEFNAEP
HVRGTCSMARTNFPHSANSQFFICFDDARFLDKQYTVWGKVVEGMDVVDTINKGEPPRSPDKIVKATVAAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=40.2985074626866, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=34.4370860927152, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI24308049, Length=158, Percent_Identity=36.7088607594937, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI64276486, Length=152, Percent_Identity=36.1842105263158, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031987, Length=143, Percent_Identity=41.2587412587413, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=39.0625, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI22547212, Length=134, Percent_Identity=41.7910447761194, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI7657473, Length=134, Percent_Identity=41.7910447761194, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI22547215, Length=134, Percent_Identity=41.7910447761194, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4505991, Length=128, Percent_Identity=40.625, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI45439316, Length=132, Percent_Identity=37.1212121212121, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI256017253, Length=143, Percent_Identity=35.6643356643357, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI221139811, Length=143, Percent_Identity=35.6643356643357, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI256017251, Length=143, Percent_Identity=35.6643356643357, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI20911035, Length=140, Percent_Identity=37.1428571428571, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI303305009, Length=128, Percent_Identity=36.71875, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5174637, Length=128, Percent_Identity=36.71875, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310129267, Length=127, Percent_Identity=37.007874015748, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310120620, Length=127, Percent_Identity=37.007874015748, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=39.0625, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI4758950, Length=147, Percent_Identity=36.734693877551, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1789763, Length=134, Percent_Identity=41.044776119403, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1786736, Length=144, Percent_Identity=38.8888888888889, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=155, Percent_Identity=39.3548387096774, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=42.7480916030534, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=137, Percent_Identity=39.4160583941606, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=39.7163120567376, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=143, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=145, Percent_Identity=37.2413793103448, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=143, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=140, Percent_Identity=32.8571428571429, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=133, Percent_Identity=34.5864661654135, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=133, Percent_Identity=36.0902255639098, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=151, Percent_Identity=35.7615894039735, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=131, Percent_Identity=38.9312977099237, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=156, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=146, Percent_Identity=38.3561643835616, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=135, Percent_Identity=38.5185185185185, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=131, Percent_Identity=36.6412213740458, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=38.3116883116883, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922376, Length=134, Percent_Identity=35.8208955223881, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=41.40625, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=41.40625, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549139, Length=157, Percent_Identity=38.2165605095541, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=36.8421052631579, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=38.28125, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922912, Length=143, Percent_Identity=44.0559440559441, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130249, Length=145, Percent_Identity=37.2413793103448, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136360, Length=129, Percent_Identity=35.6589147286822, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16437; Mature: 16305

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNETIVLETTKGRVVIALRPDLAPGHVERIKTLAAQGFYDGVPFHRVIDGFMAQTGDP
CCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
TGTGSGGSDLPDLKAEFNAEPHVRGTCSMARTNFPHSANSQFFICFDDARFLDKQYTVWG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
KVVEGMDVVDTINKGEPPRSPDKIVKATVAAA
HHHCCCHHHHHCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ADNETIVLETTKGRVVIALRPDLAPGHVERIKTLAAQGFYDGVPFHRVIDGFMAQTGDP
CCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
TGTGSGGSDLPDLKAEFNAEPHVRGTCSMARTNFPHSANSQFFICFDDARFLDKQYTVWG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
KVVEGMDVVDTINKGEPPRSPDKIVKATVAAA
HHHCCCHHHHHCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA