Click here to switch to the map view.

The map label for this gene is cya [H]

Identifier: 170748514

GI number: 170748514

Start: 2226806

End: 2227771

Strand: Reverse

Name: cya [H]

Synonym: Mrad2831_2096

Alternate gene names: 170748514

Gene position: 2227771-2226806 (Counterclockwise)

Preceding gene: 170748515

Following gene: 170748512

Centisome position: 36.65

GC content: 79.19

Gene sequence:

>966_bases
ATGCCCGCGATGGCGCTCCGGCAGCCCCGCGCGGACAGAGCGGACGCCTGTCCCGGCCGCGCGGGGGGTGCCGGGCGACG
GGCGGGGACCGCCCCGATCCGCCGACGCCTCGCCGTCGCGGCGGCGGAGCACGGCCGGCTCCTCGCCGCGGCGCCCCTGC
CGCTGCTCCTGGCGCTCGCGGCCACGACGACGCCGGAGCCGGTCACCCTCGGGCTCGGCGGCCTCGCCCTGGCGTGGCTC
TCGCTGCGGGTGCAGCGCCTGCGCGGAGCCGCGCGCGCCGCGACGCGCCAGCGGAACAACCTCGCGCGCCTGACCGCGCC
GACGGTCGCCCGATGGGTCGCCGAGACGGATCGCGCCGCCCGGCGCCCCGGCTGGGAGCAGGAGGCGACGGTGCTCTTCG
CCGACATCCGCGGTTTCACCCGCCTCTGCGAGGGCATGGCGCCCGGCGAGGTCGCAGATTTCCTCGCCGCGTTCCGGTCC
CGCGCCGCGCGCGCGATCGAGGCGGCGGGCGGGCTCGTCGACAAGTTCGTCGGCGACGAGGTGATGGCGGTGTTCGGCGT
GCCGGACGCGGCGGCCGGGGACGCCGAGCGCGCCATCGCGGCGGCGCGCGCGCTCGCGGCCGCGATGGCGGCCTGGAGCC
GGGAGCGCGGGGAGGCCGGCCAGCCGCCGGTGCGGCTCGGCATCGGACTGCATCGCGGCCCGGTCTTCATCGGCGTCATC
GGGGCGGAGCGCATCGAGTTCACGGCGGTCGGCGACACCGTCAACGTGGCCCGTCGCCTGGAACAGATGACCCGCGCGCT
GCCCTGCGACTGCCTCGCCTCGGAGGCGGTGGTGCGGGCCGCGCCGTCCGGCGGGGCGCGGCTGATCGCCGTCGGGCCGG
TGCGCGGCGCCCGCACCGTCCTGCGCCTGTTCACCCTCCGGCTCGACCCGCCGCGGACGCGTGCGGACCGAACCGGCGCG
TCCTGA

Upstream 100 bases:

>100_bases
CACGCCCGTTCCGGACGGATCTGGACCTCCGCTCCCCCGCCGTGGCGCGCGAGCACGCGCGCGCCCAGCGCATCATCGGC
CGCGTCTGCACGGGCTGCTG

Downstream 100 bases:

>100_bases
AGACCCGGCGGGGCAGGGGGCGGCGACCGCGTCCCGCCGCCGTTCCGGATGCCGCCCTCACGCGCGGGGTCCCTCGGCGA
GATCGTCGAGGTCGACGCGC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPAMALRQPRADRADACPGRAGGAGRRAGTAPIRRRLAVAAAEHGRLLAAAPLPLLLALAATTTPEPVTLGLGGLALAWL
SLRVQRLRGAARAATRQRNNLARLTAPTVARWVAETDRAARRPGWEQEATVLFADIRGFTRLCEGMAPGEVADFLAAFRS
RAARAIEAAGGLVDKFVGDEVMAVFGVPDAAAGDAERAIAAARALAAAMAAWSRERGEAGQPPVRLGIGLHRGPVFIGVI
GAERIEFTAVGDTVNVARRLEQMTRALPCDCLASEAVVRAAPSGGARLIAVGPVRGARTVLRLFTLRLDPPRTRADRTGA
S

Sequences:

>Translated_321_residues
MPAMALRQPRADRADACPGRAGGAGRRAGTAPIRRRLAVAAAEHGRLLAAAPLPLLLALAATTTPEPVTLGLGGLALAWL
SLRVQRLRGAARAATRQRNNLARLTAPTVARWVAETDRAARRPGWEQEATVLFADIRGFTRLCEGMAPGEVADFLAAFRS
RAARAIEAAGGLVDKFVGDEVMAVFGVPDAAAGDAERAIAAARALAAAMAAWSRERGEAGQPPVRLGIGLHRGPVFIGVI
GAERIEFTAVGDTVNVARRLEQMTRALPCDCLASEAVVRAAPSGGARLIAVGPVRGARTVLRLFTLRLDPPRTRADRTGA
S
>Mature_320_residues
PAMALRQPRADRADACPGRAGGAGRRAGTAPIRRRLAVAAAEHGRLLAAAPLPLLLALAATTTPEPVTLGLGGLALAWLS
LRVQRLRGAARAATRQRNNLARLTAPTVARWVAETDRAARRPGWEQEATVLFADIRGFTRLCEGMAPGEVADFLAAFRSR
AARAIEAAGGLVDKFVGDEVMAVFGVPDAAAGDAERAIAAARALAAAMAAWSRERGEAGQPPVRLGIGLHRGPVFIGVIG
AERIEFTAVGDTVNVARRLEQMTRALPCDCLASEAVVRAAPSGGARLIAVGPVRGARTVLRLFTLRLDPPRTRADRTGAS

Specific function: May function as a membrane-localized receptor protein [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI4504217, Length=196, Percent_Identity=30.1020408163265, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71995893, Length=148, Percent_Identity=29.7297297297297, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995899, Length=148, Percent_Identity=29.7297297297297, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995895, Length=148, Percent_Identity=29.7297297297297, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193206632, Length=136, Percent_Identity=33.8235294117647, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71990146, Length=199, Percent_Identity=27.1356783919598, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=145, Percent_Identity=31.7241379310345, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484477, Length=208, Percent_Identity=27.8846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62484298, Length=208, Percent_Identity=27.8846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85725044, Length=200, Percent_Identity=29.5, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116008008, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330470, Length=136, Percent_Identity=33.8235294117647, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330468, Length=136, Percent_Identity=33.8235294117647, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366459, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366457, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366455, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292422, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292424, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666940, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 33581; Mature: 33450

Theoretical pI: Translated: 12.01; Mature: 12.01

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMALRQPRADRADACPGRAGGAGRRAGTAPIRRRLAVAAAEHGRLLAAAPLPLLLALA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
ATTTPEPVTLGLGGLALAWLSLRVQRLRGAARAATRQRNNLARLTAPTVARWVAETDRAA
HCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RRPGWEQEATVLFADIRGFTRLCEGMAPGEVADFLAAFRSRAARAIEAAGGLVDKFVGDE
HCCCCCCHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCH
VMAVFGVPDAAAGDAERAIAAARALAAAMAAWSRERGEAGQPPVRLGIGLHRGPVFIGVI
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEECCCEEEEEE
GAERIEFTAVGDTVNVARRLEQMTRALPCDCLASEAVVRAAPSGGARLIAVGPVRGARTV
CCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
LRLFTLRLDPPRTRADRTGAS
HHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAMALRQPRADRADACPGRAGGAGRRAGTAPIRRRLAVAAAEHGRLLAAAPLPLLLALA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
ATTTPEPVTLGLGGLALAWLSLRVQRLRGAARAATRQRNNLARLTAPTVARWVAETDRAA
HCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RRPGWEQEATVLFADIRGFTRLCEGMAPGEVADFLAAFRSRAARAIEAAGGLVDKFVGDE
HCCCCCCHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCH
VMAVFGVPDAAAGDAERAIAAARALAAAMAAWSRERGEAGQPPVRLGIGLHRGPVFIGVI
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEECCCEEEEEE
GAERIEFTAVGDTVNVARRLEQMTRALPCDCLASEAVVRAAPSGGARLIAVGPVRGARTV
CCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
LRLFTLRLDPPRTRADRTGAS
HHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7601856 [H]