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The map label for this gene is nuoL [H]

Identifier: 170748466

GI number: 170748466

Start: 2178187

End: 2180295

Strand: Reverse

Name: nuoL [H]

Synonym: Mrad2831_2048

Alternate gene names: 170748466

Gene position: 2180295-2178187 (Counterclockwise)

Preceding gene: 170748467

Following gene: 170748465

Centisome position: 35.87

GC content: 67.28

Gene sequence:

>2109_bases
ATGTATCACGCGATCGTCTTCTTCCCGCTCATCGGCTTCCTGATCGCCGGCCTGTTCGGCCGGTACATCGGGGCGCGGGC
CTGTGAGTACATCACCACGGCGTTCCTGGCCTTCACGGCGCTGATCGCCTGGGGCGTGTTTCTCGACGGCGGCCACGCCG
AGCGGGTGCAGGTTGCGTCCTGGTTCTCGGCCGGCGACCTGCAGGTCGACTGGGCCTTCAAGGTCGACACCCTGACGCGG
GTGATGCTGGTCGTCGTGACCACCGTCTCGACCCTCGTGCACCTCTACTCCGTGGGCTACATGGAGGAGGACCCGCACCG
GCCGCGCTTCTTCGCCTACCTGTCGCTGTTCACCTTCGCCATGCTGATGCTGGTGACGGCCGACAACCTCGTGCAGATGT
TCTTCGGCTGGGAGGGCGTGGGCCTCGCCTCCTACCTGCTGATCGGGTTCTGGTACGAGAAGCCCTCGGCCAACGCCGCC
GCCATGAAGGCGTTCATCGTCAACCGCGTGGGCGATTTCGGCTTCTCCCTCGGCATCTTCCTGACCTTCGTGCTCACCGG
CTCGGTGGCCTTCGACGCGATCTTCGGCAAGGTCGACGCGATCAAGACGCTCACCTTCCACTTCCTCGGCTACGACTGGA
ACGCGCTGACCCTCGCCTGCCTGCTGCTGTTCATGGGCGCCATGGGCAAGTCGGCGCAGTTCCTGCTGCACACGTGGCTC
CCGGACGCGATGGAGGGCCCGACACCGGTCTCGGCGCTGATCCACGCCGCCACCATGGTGACCGCGGGCGTGTTCATGGT
CGCGCGCCTCTCGCCGCTCTTCGAGGAGGCGCCGAACGCGCTCATCGTCGTGACGGTGATCGGCGGCATCACGGCGTTCT
TCGCGGCCACGATCGGGCTGGTGCAGAACGACATCAAGCGGGTGATCGCCTACTCGACCTGCTCGCAGCTCGGCTACATG
TTCGTGGCGCTCGGCGTCGGCGCCTACTCGGCCGGCGTGTTCCACCTCTTCACCCACGCCTTCTTCAAGGCGCTGCTGTT
CCTCGGGGCCGGCTCGGTCATCCACGCGATGCACCACGAGCAGGACATGCGGAACATGGGCGGCCTGCGCCGCTACATCC
CCTACACCAGCGCCATGATGGCGATCGGCTCCCTGGCGCTGATCGGCTTCCCCTACACGGCCGGCTACTACTCGAAGGAC
GCGATCATCGAGGCCGCCTACGCGTCGACCCGGCCGGGCCACACCCTCGCCTTCCTGTGCGTCGTGGTGGCGGCGTTCTT
CACCTCGTTCTACTCGTGGCGCCTGTTCTTCATGACCTTCGAGGGTCCGGCGCGCTGGGGCGCGCACGCGGCCCACGGTC
ACCACGACGCCCCAGCGGTCGCGCACTCCACCATGGCGCACGAGGCCGACGGCGCGCCGGGCCACACCGAGGGCGTCGCC
CACGACGACAAGGGCCACGACGTCGAGCCGGCGCACAGGAGCGACCTCGTCGCCGACGACCATCACGGCCACGGCCACCA
CGGCGACCACACGCCCCACGAGAGCCCGCTGGTGATGACGATCCCGCTGGCGATCCTCGCCTTCGGCGCGCTGTTCGCCG
GGATCATCTTCCACAACCGCTTCATCGGCGAGGGGATGGACGCGTTCTGGGGCCACGCCCTGGCGCACGGGCCGAACAAC
CACATCATGCACGAGATCCACGAGGTCCCGGCTCTGGTCTCCTACTCGCCGCTCGTCATGCTGATCCTCGGCTTCGTCCT
GGCCTACTGGATGTACATCCGCCGGCCGGAGCTTCCGGGCCAGCTCGCCGCGCAGCAGCCGTCGCTGTACCGGTTCCTGC
TCAACAAGTGGTACTTCGACGAGATCTACGACCGGATCTTCGTCCGCCCGGCCAAGGATTTCGGCCTGTTCCTCTGGAAG
GAGGGCGACGGCCGGATCATCGACGGCCTCGGCCCCAACGGCATCGCGGCGCGCGTCGTGGACGTGACCCGCGGGGTCGT
CCGGCTCCAGACCGGCTACCTGTACCATTACGCCTTCGTGATGCTCATCGGCGTCGCCGGCCTGATCAGCTGGTACCTGA
TGTCCGGCCTGCCCAAGGGTGCTCACTGA

Upstream 100 bases:

>100_bases
AGCATGATGAAGGGCTAGGGCCTTCACCTTCGCGCGCCCCGAGTGACATCCGGACGCCGCCGCCTCGCGGCCGGCCCGGA
GGACGGACTGCAAGAGAGCG

Downstream 100 bases:

>100_bases
TATGCTCGGCCTCGGCATCCTCTCCGGCCTGCTGATCGTGCCGCTCTGCGGCGCGGCCTTCATCCTGACGCTGAACGGCG
ACGAGGAATCGGTCGCGCGC

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MYHAIVFFPLIGFLIAGLFGRYIGARACEYITTAFLAFTALIAWGVFLDGGHAERVQVASWFSAGDLQVDWAFKVDTLTR
VMLVVVTTVSTLVHLYSVGYMEEDPHRPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWYEKPSANAA
AMKAFIVNRVGDFGFSLGIFLTFVLTGSVAFDAIFGKVDAIKTLTFHFLGYDWNALTLACLLLFMGAMGKSAQFLLHTWL
PDAMEGPTPVSALIHAATMVTAGVFMVARLSPLFEEAPNALIVVTVIGGITAFFAATIGLVQNDIKRVIAYSTCSQLGYM
FVALGVGAYSAGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRNMGGLRRYIPYTSAMMAIGSLALIGFPYTAGYYSKD
AIIEAAYASTRPGHTLAFLCVVVAAFFTSFYSWRLFFMTFEGPARWGAHAAHGHHDAPAVAHSTMAHEADGAPGHTEGVA
HDDKGHDVEPAHRSDLVADDHHGHGHHGDHTPHESPLVMTIPLAILAFGALFAGIIFHNRFIGEGMDAFWGHALAHGPNN
HIMHEIHEVPALVSYSPLVMLILGFVLAYWMYIRRPELPGQLAAQQPSLYRFLLNKWYFDEIYDRIFVRPAKDFGLFLWK
EGDGRIIDGLGPNGIAARVVDVTRGVVRLQTGYLYHYAFVMLIGVAGLISWYLMSGLPKGAH

Sequences:

>Translated_702_residues
MYHAIVFFPLIGFLIAGLFGRYIGARACEYITTAFLAFTALIAWGVFLDGGHAERVQVASWFSAGDLQVDWAFKVDTLTR
VMLVVVTTVSTLVHLYSVGYMEEDPHRPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWYEKPSANAA
AMKAFIVNRVGDFGFSLGIFLTFVLTGSVAFDAIFGKVDAIKTLTFHFLGYDWNALTLACLLLFMGAMGKSAQFLLHTWL
PDAMEGPTPVSALIHAATMVTAGVFMVARLSPLFEEAPNALIVVTVIGGITAFFAATIGLVQNDIKRVIAYSTCSQLGYM
FVALGVGAYSAGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRNMGGLRRYIPYTSAMMAIGSLALIGFPYTAGYYSKD
AIIEAAYASTRPGHTLAFLCVVVAAFFTSFYSWRLFFMTFEGPARWGAHAAHGHHDAPAVAHSTMAHEADGAPGHTEGVA
HDDKGHDVEPAHRSDLVADDHHGHGHHGDHTPHESPLVMTIPLAILAFGALFAGIIFHNRFIGEGMDAFWGHALAHGPNN
HIMHEIHEVPALVSYSPLVMLILGFVLAYWMYIRRPELPGQLAAQQPSLYRFLLNKWYFDEIYDRIFVRPAKDFGLFLWK
EGDGRIIDGLGPNGIAARVVDVTRGVVRLQTGYLYHYAFVMLIGVAGLISWYLMSGLPKGAH
>Mature_702_residues
MYHAIVFFPLIGFLIAGLFGRYIGARACEYITTAFLAFTALIAWGVFLDGGHAERVQVASWFSAGDLQVDWAFKVDTLTR
VMLVVVTTVSTLVHLYSVGYMEEDPHRPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWYEKPSANAA
AMKAFIVNRVGDFGFSLGIFLTFVLTGSVAFDAIFGKVDAIKTLTFHFLGYDWNALTLACLLLFMGAMGKSAQFLLHTWL
PDAMEGPTPVSALIHAATMVTAGVFMVARLSPLFEEAPNALIVVTVIGGITAFFAATIGLVQNDIKRVIAYSTCSQLGYM
FVALGVGAYSAGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRNMGGLRRYIPYTSAMMAIGSLALIGFPYTAGYYSKD
AIIEAAYASTRPGHTLAFLCVVVAAFFTSFYSWRLFFMTFEGPARWGAHAAHGHHDAPAVAHSTMAHEADGAPGHTEGVA
HDDKGHDVEPAHRSDLVADDHHGHGHHGDHTPHESPLVMTIPLAILAFGALFAGIIFHNRFIGEGMDAFWGHALAHGPNN
HIMHEIHEVPALVSYSPLVMLILGFVLAYWMYIRRPELPGQLAAQQPSLYRFLLNKWYFDEIYDRIFVRPAKDFGLFLWK
EGDGRIIDGLGPNGIAARVVDVTRGVVRLQTGYLYHYAFVMLIGVAGLISWYLMSGLPKGAH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cellular chromatophore membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=385, Percent_Identity=43.3766233766234, Blast_Score=304, Evalue=2e-82,
Organism=Escherichia coli, GI1788614, Length=472, Percent_Identity=45.3389830508475, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1788829, Length=423, Percent_Identity=30.2600472813239, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=30.9859154929577, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788827, Length=363, Percent_Identity=29.2011019283747, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788613, Length=425, Percent_Identity=24, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693160, Length=364, Percent_Identity=24.4505494505494, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI2367154, Length=152, Percent_Identity=30.9210526315789, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 77200; Mature: 77200

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]