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The map label for this gene is lolC [H]

Identifier: 170748458

GI number: 170748458

Start: 2168590

End: 2169900

Strand: Reverse

Name: lolC [H]

Synonym: Mrad2831_2040

Alternate gene names: 170748458

Gene position: 2169900-2168590 (Counterclockwise)

Preceding gene: 170748459

Following gene: 170748457

Centisome position: 35.7

GC content: 69.57

Gene sequence:

>1311_bases
ATGGCCGCCTCAGCGAAGCTGGACCGGGTTCGGACCTTCGCGGCCTCGCTCGCGGCCTCGTTCCGCCAGGGCACCGCGCC
CTTCGCGCCGTTCGAGTGGATCCTCGCCGGCCGCTACCTGCGCGCCCGGCGCCGGGGCGGCGGCGTCTCGGTGGTGGCGT
TCTTCTCGGTGCTCGGCATCGCGCTCGGCGTCGCCACGCTGATCATCGTCCTGTCGGTGATGAACGGCTTCCGGGCGGAA
CTGCTGTCGAAGATCGTCGGCATCAACGGCCACCTGTTCGCGACGCCCATCGACCGGCCGTTCAACGACTGGACCGACCT
GTCGGAGCGCCTGTCGAAGGTGGCGGGCGTGCGCGCGGCGGTGCCGCTGGTCGAGGGCCAGGCCTTCGCCTCCTCGCAGT
ATGGCGGCTCGGGGGTGATCATCCGCGGCGTGCGGGCGGCCGACCTCGACGCGCTGGCGGCCGTCTCCTCGGCGATCCGC
GGCGGCACCCTGGAGGGCTTCGACGACGGCACGGGCGTGCTGATCGGGCGGCGGCTCGCCGACACGCTGGGCCTGCAGGC
CGGCGACACGATCACGCTGGTCACGCCCAAGGGCTCGTCCACGCCCTTCGGGACGGCGCCGCGCACCAAGAGCTACACCG
TCAAGGCGGTCTTCGAAGTCGGCATGACCGAGTTCGACCAGACCTTCGTGTTCATGCCGCTGACCGAGGCCCAGGCCTTC
TTCAACAAGGACGGCGACGTGAGCATGATCGAGATCTACGTCGACGATCCCGACCACGTCGGCGACATGCGCGAGCCCCT
GGAGATGGCGGCCGAGCGCCCGATCCTGCTCACCGACTGGCGCCAGCGCAACCGGACCTTCTTCGGGGCCCTGGAGGTCG
AGCGGAACGTCATGTTCCTGATCCTCAGCCTGATCGTCGTGGTGGCGACGCTCAACATCGTCTCCGGCCTGATCCTGCTG
GTGCGCGACAAGTCGAGCGACATCGCCATCCTGCGCACCATGGGGGCGACCCCGGGCACGATCATGCGGGTGTTCCTGAT
CAACGGTGCGCTGATCGGCGTCGTCGGGACGCTCAGCGGGCTGGGGCTCGGCGTCCTGATCACCCTCAACATCAAGCCGA
TCCAGCACGTGCTGTTTCCGGGCGCCTGGGACCCCACGGTGCGGTTCCTCGCCGAGATCCCGGCCCAGATGAACCCGAAG
GAGATCACTGCCGTGGTGATCACCTCCCTGCTGCTGTCGCTCGCGGCGACGCTGTATCCCTCCTGGCGCGCCGCCCGGCT
CGATCCGGTGCAGGCCCTCCGCTACGGCTGA

Upstream 100 bases:

>100_bases
GGAGGGCAAGGTCGAGCTGAAGCGGCGTGCCGGCGGCGAGCGCGAGAGCCTCGCGACCGTCGATCTGCTGGCACGCATCC
GGCGCGTCTGAGGCGTGCCG

Downstream 100 bases:

>100_bases
CGGGCCCATCCAATGAGCGATTCGAGCCAGACCGCCGGCGACCCGCCGGTGCCGGCCCTGTTCTTCTCCCGCGTCGAGCG
GCGCTACGCCCAGGCCGAGG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAASAKLDRVRTFAASLAASFRQGTAPFAPFEWILAGRYLRARRRGGGVSVVAFFSVLGIALGVATLIIVLSVMNGFRAE
LLSKIVGINGHLFATPIDRPFNDWTDLSERLSKVAGVRAAVPLVEGQAFASSQYGGSGVIIRGVRAADLDALAAVSSAIR
GGTLEGFDDGTGVLIGRRLADTLGLQAGDTITLVTPKGSSTPFGTAPRTKSYTVKAVFEVGMTEFDQTFVFMPLTEAQAF
FNKDGDVSMIEIYVDDPDHVGDMREPLEMAAERPILLTDWRQRNRTFFGALEVERNVMFLILSLIVVVATLNIVSGLILL
VRDKSSDIAILRTMGATPGTIMRVFLINGALIGVVGTLSGLGLGVLITLNIKPIQHVLFPGAWDPTVRFLAEIPAQMNPK
EITAVVITSLLLSLAATLYPSWRAARLDPVQALRYG

Sequences:

>Translated_436_residues
MAASAKLDRVRTFAASLAASFRQGTAPFAPFEWILAGRYLRARRRGGGVSVVAFFSVLGIALGVATLIIVLSVMNGFRAE
LLSKIVGINGHLFATPIDRPFNDWTDLSERLSKVAGVRAAVPLVEGQAFASSQYGGSGVIIRGVRAADLDALAAVSSAIR
GGTLEGFDDGTGVLIGRRLADTLGLQAGDTITLVTPKGSSTPFGTAPRTKSYTVKAVFEVGMTEFDQTFVFMPLTEAQAF
FNKDGDVSMIEIYVDDPDHVGDMREPLEMAAERPILLTDWRQRNRTFFGALEVERNVMFLILSLIVVVATLNIVSGLILL
VRDKSSDIAILRTMGATPGTIMRVFLINGALIGVVGTLSGLGLGVLITLNIKPIQHVLFPGAWDPTVRFLAEIPAQMNPK
EITAVVITSLLLSLAATLYPSWRAARLDPVQALRYG
>Mature_435_residues
AASAKLDRVRTFAASLAASFRQGTAPFAPFEWILAGRYLRARRRGGGVSVVAFFSVLGIALGVATLIIVLSVMNGFRAEL
LSKIVGINGHLFATPIDRPFNDWTDLSERLSKVAGVRAAVPLVEGQAFASSQYGGSGVIIRGVRAADLDALAAVSSAIRG
GTLEGFDDGTGVLIGRRLADTLGLQAGDTITLVTPKGSSTPFGTAPRTKSYTVKAVFEVGMTEFDQTFVFMPLTEAQAFF
NKDGDVSMIEIYVDDPDHVGDMREPLEMAAERPILLTDWRQRNRTFFGALEVERNVMFLILSLIVVVATLNIVSGLILLV
RDKSSDIAILRTMGATPGTIMRVFLINGALIGVVGTLSGLGLGVLITLNIKPIQHVLFPGAWDPTVRFLAEIPAQMNPKE
ITAVVITSLLLSLAATLYPSWRAARLDPVQALRYG

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=390, Percent_Identity=29.4871794871795, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=31.4769975786925, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46751; Mature: 46620

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASAKLDRVRTFAASLAASFRQGTAPFAPFEWILAGRYLRARRRGGGVSVVAFFSVLGI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALGVATLIIVLSVMNGFRAELLSKIVGINGHLFATPIDRPFNDWTDLSERLSKVAGVRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCHHHH
VPLVEGQAFASSQYGGSGVIIRGVRAADLDALAAVSSAIRGGTLEGFDDGTGVLIGRRLA
CEEECCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
DTLGLQAGDTITLVTPKGSSTPFGTAPRTKSYTVKAVFEVGMTEFDQTFVFMPLTEAQAF
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHCCHHHCCEEEEEEEHHHHHH
FNKDGDVSMIEIYVDDPDHVGDMREPLEMAAERPILLTDWRQRNRTFFGALEVERNVMFL
HCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEECHHHCCCEEEEEEEHHHHHHHH
ILSLIVVVATLNIVSGLILLVRDKSSDIAILRTMGATPGTIMRVFLINGALIGVVGTLSG
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHC
LGLGVLITLNIKPIQHVLFPGAWDPTVRFLAEIPAQMNPKEITAVVITSLLLSLAATLYP
CCEEEEEEEECCHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
SWRAARLDPVQALRYG
CCCCCCCCHHHHHCCC
>Mature Secondary Structure 
AASAKLDRVRTFAASLAASFRQGTAPFAPFEWILAGRYLRARRRGGGVSVVAFFSVLGI
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALGVATLIIVLSVMNGFRAELLSKIVGINGHLFATPIDRPFNDWTDLSERLSKVAGVRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCHHHH
VPLVEGQAFASSQYGGSGVIIRGVRAADLDALAAVSSAIRGGTLEGFDDGTGVLIGRRLA
CEEECCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
DTLGLQAGDTITLVTPKGSSTPFGTAPRTKSYTVKAVFEVGMTEFDQTFVFMPLTEAQAF
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHCCHHHCCEEEEEEEHHHHHH
FNKDGDVSMIEIYVDDPDHVGDMREPLEMAAERPILLTDWRQRNRTFFGALEVERNVMFL
HCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEECHHHCCCEEEEEEEHHHHHHHH
ILSLIVVVATLNIVSGLILLVRDKSSDIAILRTMGATPGTIMRVFLINGALIGVVGTLSG
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHC
LGLGVLITLNIKPIQHVLFPGAWDPTVRFLAEIPAQMNPKEITAVVITSLLLSLAATLYP
CCEEEEEEEECCHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
SWRAARLDPVQALRYG
CCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]