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The map label for this gene is atpB [H]

Identifier: 170747148

GI number: 170747148

Start: 752414

End: 753169

Strand: Reverse

Name: atpB [H]

Synonym: Mrad2831_0714

Alternate gene names: 170747148

Gene position: 753169-752414 (Counterclockwise)

Preceding gene: 170747149

Following gene: 170747147

Centisome position: 12.39

GC content: 64.15

Gene sequence:

>756_bases
ATGGCGGTCACGATCGACCCGATCCATCAGTTCGAGCTGAAGCCGCTCGTTTCGCTGGGCCATATCGGCCACCAGCAGCT
CGCGTTCACGCAGTCGGCCCTCTACATGTTCGCCGCCGTCGGTGTGATCGCGCTCATCACCATCGTGGCGACCGCGTCCC
GCTCGATCGTTCCGGGCCGCATGCAGTCGCTGGCCGAGATCTTCTACGAGTTCATCGCCGACACCGTGCACCAGGCGACG
GGCGACGGCGGCAAGCGGTTCATGCCGCTCGTGTTCTCGCTGTTCATGTTCGTGCTCGTCCTGAACCTGTTCGGGATGAT
CCCCTACGCCTTCGCGGTGACCAGCCACCTGATCATCACCTTCGGCCTCGCGGCGCTGGTGATCTCCACCGTGGTGATCT
TCGGCGTGATGAAGCACGGCACCCACTTCTTCGGCCTGTTCGTGCCGTCGGGCGTGCCGAAGCCGCTCCTCGCGATCCTG
GTGCCGATCGAGGTGATCTCGTTCATCTCGCGCCCGATCAGCCTGTCGGTCCGTCTGTTCGCCAACATGCTGGCCGGCCA
CATCGCGATGAAGATCTTCGCCTTCTTCGTGGTTCAGCTCCTTCTCGCGGGCGCCTGGAGCGTGCTATCGCCGCTCCCGC
TGTTCCTGACGATCGCGCTGACCGCTCTCGAGTTCCTCGTTGCGGCGCTTCAGGCCTACGTCTTCGCGACGCTGACGGCG
ATCTACCTCAACGACGCCCTTCACCCCGGCCACTGA

Upstream 100 bases:

>100_bases
GACGGCGCGATCGGCAGGAGCCATAAGGCGCGCCGGTCAGTGGGGAATGTGGGGCGGCCGACACCCGTCGGCGCGCCGGA
CAAGAAGGGCGGAAGCGGGA

Downstream 100 bases:

>100_bases
TCGGCCGGCTCCACCCGCCGCAAACGTCATCGCACGTTTCGATCTGAAGAGACCTCAGGAGTTACCATGGATCCCGTCGC
TGCGAAGTACATCGGCGCCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MAVTIDPIHQFELKPLVSLGHIGHQQLAFTQSALYMFAAVGVIALITIVATASRSIVPGRMQSLAEIFYEFIADTVHQAT
GDGGKRFMPLVFSLFMFVLVLNLFGMIPYAFAVTSHLIITFGLAALVISTVVIFGVMKHGTHFFGLFVPSGVPKPLLAIL
VPIEVISFISRPISLSVRLFANMLAGHIAMKIFAFFVVQLLLAGAWSVLSPLPLFLTIALTALEFLVAALQAYVFATLTA
IYLNDALHPGH

Sequences:

>Translated_251_residues
MAVTIDPIHQFELKPLVSLGHIGHQQLAFTQSALYMFAAVGVIALITIVATASRSIVPGRMQSLAEIFYEFIADTVHQAT
GDGGKRFMPLVFSLFMFVLVLNLFGMIPYAFAVTSHLIITFGLAALVISTVVIFGVMKHGTHFFGLFVPSGVPKPLLAIL
VPIEVISFISRPISLSVRLFANMLAGHIAMKIFAFFVVQLLLAGAWSVLSPLPLFLTIALTALEFLVAALQAYVFATLTA
IYLNDALHPGH
>Mature_250_residues
AVTIDPIHQFELKPLVSLGHIGHQQLAFTQSALYMFAAVGVIALITIVATASRSIVPGRMQSLAEIFYEFIADTVHQATG
DGGKRFMPLVFSLFMFVLVLNLFGMIPYAFAVTSHLIITFGLAALVISTVVIFGVMKHGTHFFGLFVPSGVPKPLLAILV
PIEVISFISRPISLSVRLFANMLAGHIAMKIFAFFVVQLLLAGAWSVLSPLPLFLTIALTALEFLVAALQAYVFATLTAI
YLNDALHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=213, Percent_Identity=30.0469483568075, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6226527, Length=247, Percent_Identity=36.8421052631579, Blast_Score=148, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 27184; Mature: 27053

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCC
>Mature Secondary Structure 
AVTIDPIHQFELKPLVSLGHIGHQQLAFTQSALYMFAAVGVIALITIVATASRSIVPGR
CEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MQSLAEIFYEFIADTVHQATGDGGKRFMPLVFSLFMFVLVLNLFGMIPYAFAVTSHLIIT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLAALVISTVVIFGVMKHGTHFFGLFVPSGVPKPLLAILVPIEVISFISRPISLSVRLF
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ANMLAGHIAMKIFAFFVVQLLLAGAWSVLSPLPLFLTIALTALEFLVAALQAYVFATLTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLNDALHPGH
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA