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The map label for this gene is ilvA [H]

Identifier: 170747061

GI number: 170747061

Start: 672889

End: 674418

Strand: Reverse

Name: ilvA [H]

Synonym: Mrad2831_0627

Alternate gene names: 170747061

Gene position: 674418-672889 (Counterclockwise)

Preceding gene: 170747062

Following gene: 170747057

Centisome position: 11.1

GC content: 71.63

Gene sequence:

>1530_bases
GTGACGGACTACATCCGCAAGATCCTCACCGCCCGCGTCTACGACGTGGCGATCGAGAGCCCCCTCGATCCGATGCCGCG
CCTGACGCAGCGGCTCGGCCGGCCGGTCCTGCTCAAGCGCGAGGATCTCCAGCCGGTCTTCTCGTTCAAGCTGCGCGGCG
CCTACAACAAGATGTCGGGCCTGCAGCCCGACCAGATCGCCCGCGGCGTGGTCTGCGCCTCCGCGGGCAACCACGCGCAG
GGCGTCGCGCTCGCCGCCGCCAAGCTCGGCGCGCGGGCCGTGATCGTGATGCCGCGCACCACCCCCTCCATCAAGGTCGA
TGCCTGCCGGGCCCGCGGAGCCGAGGTCGTGCTGCACGGCGACGCCTTCGACGAGGCGCTGGCGCAGGCCAAGATCCTCG
AGGCCGAGCAGGGCCTGACCTTCCTGCATCCCTTCGACGATCCGGACGTGATCGCCGGCCAGGGCACCATCGGCAAGGAG
ATCCTGGAGCAGCATACCGGCCCGATCGAGGCGATCTTCGTGCCGGTGGGCGGCGGCGGGCTCGCCGCCGGGATCGCCAC
CTTCGTGAAGTACCTGCGGCCCGGCACCAAGGTGATCGGCGTCGAGCCCGAGGACGCCGCCTGCATGGCCGCGGCGCTCG
CGGCCGACACCCGGGTCAGCCTGCCCAGCGTCGGCCTGTTCGCCGACGGCGTCGCCGTGCGGCAGGCCGGCGAGGAGACC
TTCCGGCTCTGCCGCGAGCACCTCGACGAGGTCATCACCGTGGACACCGACGCCATGTGCGCCGCGGTGAAGGACATCTT
CGACGACACCCGCGCGGTCTCCGAGCCGTCCGGGGCGCTGAGCCTCGCCGGTGCCAAGCTCTACGCCGAGCGCGAGGGCG
GCGACGGCACGCTGATCGCGATCTCGTCGGGGGCGAACCTGAACTTCGACCGCCTGCGCCACATCGCCGAGCGCGCCGAG
ATCGGCGAACAGCGCGAGGTCCTGATCGGCGTGACGATCCCGGAACGTCCGGGCGCCTATCGCGCCTTCATCCAGGCGCT
CGGTCCGCGCGCCGTCACCGAGTTCAACTACCGCCACGCCCCGGGCTCCGAGGCGCAGATCTTCGTGGGCATCAACGTCG
GCGGCGGCAAGCGCGAGAAGCAGGAGCTGATCGGCTCGCTGCGGGAGGCCGGCTACCGCGTCCTCGACATGAGCGACAAC
GAGATGGCGAAGGTCCACGTCCGCTACATGGTCGGCGGCCGGGCCGTCGGCGTGGCGCACGAGCGCCTGTTCCGCTTCCA
GTTCCCGGAGCGGCCGGGCGCGCTGATGAAGTTCCTAGAAGCGCTGGGCCCGGACTTCGACATCACGCTGTTCCACTACC
GCAACCACGGCGCCGATTACGGCCGTGTGCTCGCCGGGATCGCGGTGCCGCCGGCCGAGCGCGCCCGGTTCGACGCCGTC
ATCGAGGCGCTCGGCTACCCGGCCACCGACGAGACCGAGAACCCGGCGTACCGCCTGTTCCTCGACGGCGAGGGCGCCGG
GGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCCTCGGCTGACCTGCCGCGCGCGGGCCGCGCTCGCATCCGCGGGCCGGAGGGTCTATCTGGCCGGCATCGCCCCGCGC
ATCGGCCGAGACTCCACACC

Downstream 100 bases:

>100_bases
GCACCGCGTCGGACGCGGTCAGCTCTCCGCCACGTCGACGGAGGTGACGTCCGGCATCGCCCGCAGCTTCGCCGCGATCG
TCTCGAAGCTCGTCCGCGAC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTDYIRKILTARVYDVAIESPLDPMPRLTQRLGRPVLLKREDLQPVFSFKLRGAYNKMSGLQPDQIARGVVCASAGNHAQ
GVALAAAKLGARAVIVMPRTTPSIKVDACRARGAEVVLHGDAFDEALAQAKILEAEQGLTFLHPFDDPDVIAGQGTIGKE
ILEQHTGPIEAIFVPVGGGGLAAGIATFVKYLRPGTKVIGVEPEDAACMAAALAADTRVSLPSVGLFADGVAVRQAGEET
FRLCREHLDEVITVDTDAMCAAVKDIFDDTRAVSEPSGALSLAGAKLYAEREGGDGTLIAISSGANLNFDRLRHIAERAE
IGEQREVLIGVTIPERPGAYRAFIQALGPRAVTEFNYRHAPGSEAQIFVGINVGGGKREKQELIGSLREAGYRVLDMSDN
EMAKVHVRYMVGGRAVGVAHERLFRFQFPERPGALMKFLEALGPDFDITLFHYRNHGADYGRVLAGIAVPPAERARFDAV
IEALGYPATDETENPAYRLFLDGEGAGAR

Sequences:

>Translated_509_residues
MTDYIRKILTARVYDVAIESPLDPMPRLTQRLGRPVLLKREDLQPVFSFKLRGAYNKMSGLQPDQIARGVVCASAGNHAQ
GVALAAAKLGARAVIVMPRTTPSIKVDACRARGAEVVLHGDAFDEALAQAKILEAEQGLTFLHPFDDPDVIAGQGTIGKE
ILEQHTGPIEAIFVPVGGGGLAAGIATFVKYLRPGTKVIGVEPEDAACMAAALAADTRVSLPSVGLFADGVAVRQAGEET
FRLCREHLDEVITVDTDAMCAAVKDIFDDTRAVSEPSGALSLAGAKLYAEREGGDGTLIAISSGANLNFDRLRHIAERAE
IGEQREVLIGVTIPERPGAYRAFIQALGPRAVTEFNYRHAPGSEAQIFVGINVGGGKREKQELIGSLREAGYRVLDMSDN
EMAKVHVRYMVGGRAVGVAHERLFRFQFPERPGALMKFLEALGPDFDITLFHYRNHGADYGRVLAGIAVPPAERARFDAV
IEALGYPATDETENPAYRLFLDGEGAGAR
>Mature_508_residues
TDYIRKILTARVYDVAIESPLDPMPRLTQRLGRPVLLKREDLQPVFSFKLRGAYNKMSGLQPDQIARGVVCASAGNHAQG
VALAAAKLGARAVIVMPRTTPSIKVDACRARGAEVVLHGDAFDEALAQAKILEAEQGLTFLHPFDDPDVIAGQGTIGKEI
LEQHTGPIEAIFVPVGGGGLAAGIATFVKYLRPGTKVIGVEPEDAACMAAALAADTRVSLPSVGLFADGVAVRQAGEETF
RLCREHLDEVITVDTDAMCAAVKDIFDDTRAVSEPSGALSLAGAKLYAEREGGDGTLIAISSGANLNFDRLRHIAERAEI
GEQREVLIGVTIPERPGAYRAFIQALGPRAVTEFNYRHAPGSEAQIFVGINVGGGKREKQELIGSLREAGYRVLDMSDNE
MAKVHVRYMVGGRAVGVAHERLFRFQFPERPGALMKFLEALGPDFDITLFHYRNHGADYGRVLAGIAVPPAERARFDAVI
EALGYPATDETENPAYRLFLDGEGAGAR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=263, Percent_Identity=37.2623574144487, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=32.484076433121, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI19923959, Length=311, Percent_Identity=31.1897106109325, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1790207, Length=502, Percent_Identity=56.1752988047809, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI1789505, Length=296, Percent_Identity=38.5135135135135, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71991565, Length=316, Percent_Identity=34.4936708860759, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537387, Length=321, Percent_Identity=33.9563862928349, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=253, Percent_Identity=31.6205533596838, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=51.556420233463, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322631, Length=302, Percent_Identity=36.4238410596026, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=243, Percent_Identity=28.3950617283951, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355833, Length=317, Percent_Identity=35.3312302839117, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645328, Length=242, Percent_Identity=34.7107438016529, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 54695; Mature: 54564

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYIRKILTARVYDVAIESPLDPMPRLTQRLGRPVLLKREDLQPVFSFKLRGAYNKMSG
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHEEECCCHHHHCC
LQPDQIARGVVCASAGNHAQGVALAAAKLGARAVIVMPRTTPSIKVDACRARGAEVVLHG
CCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEEHHHCCCCEEEEEC
DAFDEALAQAKILEAEQGLTFLHPFDDPDVIAGQGTIGKEILEQHTGPIEAIFVPVGGGG
CHHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEEEEECCCH
LAAGIATFVKYLRPGTKVIGVEPEDAACMAAALAADTRVSLPSVGLFADGVAVRQAGEET
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCHHH
FRLCREHLDEVITVDTDAMCAAVKDIFDDTRAVSEPSGALSLAGAKLYAEREGGDGTLIA
HHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCEEEEE
ISSGANLNFDRLRHIAERAEIGEQREVLIGVTIPERPGAYRAFIQALGPRAVTEFNYRHA
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCCCC
PGSEAQIFVGINVGGGKREKQELIGSLREAGYRVLDMSDNEMAKVHVRYMVGGRAVGVAH
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEEECCEEEHHHH
ERLFRFQFPERPGALMKFLEALGPDFDITLFHYRNHGADYGRVLAGIAVPPAERARFDAV
HHHHEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHH
IEALGYPATDETENPAYRLFLDGEGAGAR
HHHHCCCCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TDYIRKILTARVYDVAIESPLDPMPRLTQRLGRPVLLKREDLQPVFSFKLRGAYNKMSG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHEEECCCHHHHCC
LQPDQIARGVVCASAGNHAQGVALAAAKLGARAVIVMPRTTPSIKVDACRARGAEVVLHG
CCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEEHHHCCCCEEEEEC
DAFDEALAQAKILEAEQGLTFLHPFDDPDVIAGQGTIGKEILEQHTGPIEAIFVPVGGGG
CHHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEEEEECCCH
LAAGIATFVKYLRPGTKVIGVEPEDAACMAAALAADTRVSLPSVGLFADGVAVRQAGEET
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCHHH
FRLCREHLDEVITVDTDAMCAAVKDIFDDTRAVSEPSGALSLAGAKLYAEREGGDGTLIA
HHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCEEEEE
ISSGANLNFDRLRHIAERAEIGEQREVLIGVTIPERPGAYRAFIQALGPRAVTEFNYRHA
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCCCC
PGSEAQIFVGINVGGGKREKQELIGSLREAGYRVLDMSDNEMAKVHVRYMVGGRAVGVAH
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEEECCEEEHHHH
ERLFRFQFPERPGALMKFLEALGPDFDITLFHYRNHGADYGRVLAGIAVPPAERARFDAV
HHHHEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHH
IEALGYPATDETENPAYRLFLDGEGAGAR
HHHHCCCCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA