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The map label for this gene is atpA

Identifier: 170747039

GI number: 170747039

Start: 648113

End: 649645

Strand: Reverse

Name: atpA

Synonym: Mrad2831_0605

Alternate gene names: 170747039

Gene position: 649645-648113 (Counterclockwise)

Preceding gene: 170747040

Following gene: 170747038

Centisome position: 10.69

GC content: 68.04

Gene sequence:

>1533_bases
ATGGACATCCGCGCCGCCGAGATCTCCGCGATCCTGAAAGACCAGATCAAGAACTTCGGCGAAGAGGCCGAGGTCTCCGA
GGTCGGGCAGGTCCTGTCCGTCGGCGACGGCATCGCCCGCGCCTACGGCCTCGACAACGTCCAGGCCGGCGAGATGGTCG
AGTTCGAGTCGGGCGTGCGCGGCATGGCCCTGAACCTCGAGCAGGACAACGTCGGCATCGTGATCTTCGGCTCCGACCGC
GAGATCAAGGAAGGTCAGACCGTCAAGCGCACCGGCGCCATCGTGGACGTGCCGGTCGGCAAGGGGCTCCTCGGCCGCGT
CGTCGACGCCCTCGGCAACCCGATCGACGGCAAGGGACCGATCCAGTCCACCGAGCGTCGCCGCGTCGACGTGAAGGCCC
CGGGCATCATCCCGCGCAAGTCGGTGCACGAGCCGATGGCCACGGGCCTCAAGGCGATCGACGCCCTGATCCCGGTGGGC
CGCGGCCAGCGCGAGCTGATCATCGGCGATCGCCAGACCGGCAAGACCGCCATCGCCCTCGACACGATCCTCAACCAGAA
GCCGGGCCACACCGCCGGCGGTGACGAGAAGGCCAAGCTCTACTGCATCTACGTCGCCATCGGCCAGAAGCGCTCGACGG
TGGCCCAGTTCGTGAAGGTGCTGGAGGACCAGGGCGCCCTGGAATACTCCATCGTCATCGCCGCCACCGCGTCGGACGCC
GCGCCGATGCAGTTCATCGCGCCCTTCGCCGGCTGCGCCATGGGCGAGTACTTCCGCGACAACGGCATGCACGCCGTGAT
CGTGTACGACGACCTGTCCAAGCAGGCCGTGGCCTACCGCCAGATGTCGCTCCTGCTGCGCCGCCCGCCGGGCCGCGAGG
CCTATCCGGGCGACGTGTTCTACCTCCACAGCCGCCTGCTGGAGCGCGCCGCCAAGATGGGCGACGCCGCCGGCGCCGGC
TCGCTGACGGCCCTGCCGGTCATCGAGACCCAGGCCAACGACGTCTCGGCCTACATTCCGACGAACGTGATCTCCATCAC
CGACGGCCAGATCTTCCTCGAGACCGACCTGTTCTACCAGGGCGTGCGCCCGGCGGTGAACGTCGGCCTCTCGGTGTCGC
GGGTGGGCTCCTCGGCCCAGACCAAGGCGATGAAGAAGGTCGCCGGCAAGATCAAGGGCGAGCTCGCGCAGTACCGCGAG
ATGGCGGCCTTCGCGCAGTTCGGCTCGGATCTCGACGCCTCGACTCAGGCGCTGCTGAACCGCGGCTCCCGCCTCACCGA
GCTCCTCAAGCAGCCGCAGTTCTCGCCGCTGAAGATGGAGGAGCAGGTCGCGGTGATCTACGCCGGCGTGAACGGCTACC
TGGACAAGCTCCCGGTGACCAAGGTCCGCGCCTTCGAGGACTCGCTGCTGAGCACCCTGCGCTCCAAGCACAAGGACCTG
CTCGACTCGATCGCCGCCTCCAAGGACCTGTCGGACGAGAACGCCGGCAAGCTCAAGAGCGTCGTCGAGAGCGTCGCCAA
GTCGATCGGCTGA

Upstream 100 bases:

>100_bases
GACCAAGCTCAACGGTATCCGCCTCGCGATGCGGGCCGCGCGATAAGCGCCCCCATCCGAACCGAACACGCATAGACGCA
TCAGCGACAGAGGCCCGAGT

Downstream 100 bases:

>100_bases
TGTGAGGCCCCTCCCCGCGGGGAGGGATCTCGGGTGGTGCGGGGGGATCCCGGTCCCCGCTGCACCGCCCGCACTTCCGG
CTCCTTCCCGCCGAGGGAAG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MDIRAAEISAILKDQIKNFGEEAEVSEVGQVLSVGDGIARAYGLDNVQAGEMVEFESGVRGMALNLEQDNVGIVIFGSDR
EIKEGQTVKRTGAIVDVPVGKGLLGRVVDALGNPIDGKGPIQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVG
RGQRELIIGDRQTGKTAIALDTILNQKPGHTAGGDEKAKLYCIYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDA
APMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMGDAAGAG
SLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQGVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYRE
MAAFAQFGSDLDASTQALLNRGSRLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVTKVRAFEDSLLSTLRSKHKDL
LDSIAASKDLSDENAGKLKSVVESVAKSIG

Sequences:

>Translated_510_residues
MDIRAAEISAILKDQIKNFGEEAEVSEVGQVLSVGDGIARAYGLDNVQAGEMVEFESGVRGMALNLEQDNVGIVIFGSDR
EIKEGQTVKRTGAIVDVPVGKGLLGRVVDALGNPIDGKGPIQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVG
RGQRELIIGDRQTGKTAIALDTILNQKPGHTAGGDEKAKLYCIYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDA
APMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMGDAAGAG
SLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQGVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYRE
MAAFAQFGSDLDASTQALLNRGSRLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVTKVRAFEDSLLSTLRSKHKDL
LDSIAASKDLSDENAGKLKSVVESVAKSIG
>Mature_510_residues
MDIRAAEISAILKDQIKNFGEEAEVSEVGQVLSVGDGIARAYGLDNVQAGEMVEFESGVRGMALNLEQDNVGIVIFGSDR
EIKEGQTVKRTGAIVDVPVGKGLLGRVVDALGNPIDGKGPIQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVG
RGQRELIIGDRQTGKTAIALDTILNQKPGHTAGGDEKAKLYCIYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDA
APMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMGDAAGAG
SLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQGVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYRE
MAAFAQFGSDLDASTQALLNRGSRLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVTKVRAFEDSLLSTLRSKHKDL
LDSIAASKDLSDENAGKLKSVVESVAKSIG

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=497, Percent_Identity=73.2394366197183, Blast_Score=748, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=497, Percent_Identity=73.2394366197183, Blast_Score=748, Evalue=0.0,
Organism=Homo sapiens, GI19913426, Length=322, Percent_Identity=27.639751552795, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI19913428, Length=307, Percent_Identity=26.7100977198697, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI32189394, Length=418, Percent_Identity=23.6842105263158, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI19913424, Length=249, Percent_Identity=26.5060240963855, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=54.7572815533981, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1790170, Length=438, Percent_Identity=23.972602739726, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788251, Length=319, Percent_Identity=28.2131661442006, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=497, Percent_Identity=72.2334004024145, Blast_Score=739, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=497, Percent_Identity=72.2334004024145, Blast_Score=738, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=497, Percent_Identity=66.5995975855131, Blast_Score=668, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17510931, Length=307, Percent_Identity=27.6872964169381, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17570191, Length=334, Percent_Identity=26.0479041916168, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=55.2631578947368, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144756, Length=391, Percent_Identity=23.7851662404092, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=64, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319370, Length=498, Percent_Identity=70.4819277108434, Blast_Score=729, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=321, Percent_Identity=29.595015576324, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=405, Percent_Identity=24.6913580246914, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=499, Percent_Identity=71.5430861723447, Blast_Score=734, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=303, Percent_Identity=27.7227722772277, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646341, Length=303, Percent_Identity=27.7227722772277, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136796, Length=303, Percent_Identity=27.7227722772277, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574560, Length=410, Percent_Identity=25.609756097561, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24638766, Length=409, Percent_Identity=23.4718826405868, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_METRJ (B1LVH1)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001753299.1
- ProteinModelPortal:   B1LVH1
- SMR:   B1LVH1
- GeneID:   6136619
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_0605
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- ProtClustDB:   PRK09281
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54607; Mature: 54607

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKDQIKNFGEEAEVSEVGQVLSVGDGIARAYGLDNVQAGEMVEFESGVR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCEEECCCCCC
GMALNLEQDNVGIVIFGSDREIKEGQTVKRTGAIVDVPVGKGLLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCC
IQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVGRGQRELIIGDRQTGKTAIAL
CCCCHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEH
DTILNQKPGHTAGGDEKAKLYCIYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDA
HHHHCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
APMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVF
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
YLHSRLLERAAKMGDAAGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQ
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHHH
GVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDASTQALLN
CCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RGSRLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVTKVRAFEDSLLSTLRSKHKDL
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LDSIAASKDLSDENAGKLKSVVESVAKSIG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKDQIKNFGEEAEVSEVGQVLSVGDGIARAYGLDNVQAGEMVEFESGVR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCEEECCCCCC
GMALNLEQDNVGIVIFGSDREIKEGQTVKRTGAIVDVPVGKGLLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCC
IQSTERRRVDVKAPGIIPRKSVHEPMATGLKAIDALIPVGRGQRELIIGDRQTGKTAIAL
CCCCHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEH
DTILNQKPGHTAGGDEKAKLYCIYVAIGQKRSTVAQFVKVLEDQGALEYSIVIAATASDA
HHHHCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
APMQFIAPFAGCAMGEYFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVF
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
YLHSRLLERAAKMGDAAGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFYQ
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHHH
GVRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDASTQALLN
CCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RGSRLTELLKQPQFSPLKMEEQVAVIYAGVNGYLDKLPVTKVRAFEDSLLSTLRSKHKDL
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LDSIAASKDLSDENAGKLKSVVESVAKSIG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA