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The map label for this gene is ywrD [H]

Identifier: 170746569

GI number: 170746569

Start: 121458

End: 123077

Strand: Reverse

Name: ywrD [H]

Synonym: Mrad2831_0119

Alternate gene names: 170746569

Gene position: 123077-121458 (Counterclockwise)

Preceding gene: 170746570

Following gene: 170746560

Centisome position: 2.03

GC content: 71.3

Gene sequence:

>1620_bases
ATGAAGCCGTTCGACTGGGTGACCGGGTATCCGTCGCTGCGGATGCCGATGTTCGGGCGCAACTGCGTGGCGACCTCGCA
CGCGCTGGCAGCGCAGGCCGGCATCCAGATGCTCCAGGCCGGCGGCAACGCCGTCGATGCCGCGATCGCCACGGCGGCCG
CCAAGACCGTGACCGAGCCGTGCAGCAACGGCCTCGGCTCGGACGCCTTCTGCATCCTGTGGGACGGGAAGGCGCTGCAC
GGCCTCAACGCTTCGGGCGGGGCTCCGGCCGCCTGGAGCCGGGACTACTTCCTGAATAAGTACGGCGCCGCCGAGCGGCC
GCCGATGCGCGGCTGGGACTCGGTCACCGTGCCGGGCGCGATCGCCGCATGGGCGGCGCTGAGCGAGCGCTTCGGCCGGC
TCCCCTTCGCCGACCTGATGCAGCCCGCGATCCGCATCGCCGAGCGCGGCTACCTCGCCCCGGTCGTGGTCCAGCAGAAA
TGGGCGGCCGCGGCCCGGATCGAGGCGATCACCCGCCAGCCGGGCTTCTCGGAGTTCTTCCTGCCGCGGGGCCGGGCACC
GGATGTCGGCGAGCTGGTGACCTTCCCCGGCGCCGAGAAGACCCTGCGGCTGATCGGCGAGACTAAGGGCGAGGCCTTCT
ACCGGGGTGAGATCGCCGAGGCGATCGCCGCGCACGCGCGGGCCAACGGCGGCGCGATGACCGCCGCCGACCTCGCGGCG
TTCCGCCCCGAATGGGTCACGCCGACCGCGAAGGATTACCACGGCTACACGCTGCACGAGATCCCGCCGAACGGCCAGGG
CATCGCGGCGCAGATCGCGCTGGGCCTCCTGGAGCAGTTCGACCTCGGCGGCCTGCCGGTCGACGGGCCGGAGTCGCAGC
ACCTGCAGATCGAGGCGATGAAGCTCGCCTTCAGCGACACCTACCGGTACGTCGCCGACCCGTGCGGGATGGAGGTGACG
CCGGAGGCCATGCTCGACCCCGCCTACCTCGCGGAGCGCGCCAAGCTGATCGACCGGAACCGCGCCCAGGTCTTCGGGCC
GGGCAAGCCGCCCGCGGGCGGCACGATCTACCTCACCGCGGCCGACGAATCCGGCATGATGGTGAGCTTCATCCAGTCGA
ACTTCATGGGCTTCGGCTCGGGCGTCGTCGTCCCGGGCTGGGGCATCTCCCTGCAGAACCGCGGCTACGGCTTCGTGCTC
GATGCGGAGAGCCCGAACGTGGTGGCGCCCGGCAAGCGGCCGTTCCACACCATCATCCCGGGCTTCCTCACGAAGGACGG
TGCGCCGGTGATGAGCTTCGGCGTGATGGGCGGCAACATGCAGCCGCAGGGGCACGTCCAGACGCTGGTGCGAATGATCG
ACCACGGCCAGAACCCGCAGTCGGCCTGCGACGCGCCGCGCTGGCGGGTCAACGAGGGCCTCGACATCAACGTCGAGGCG
GCGATGCCGGGCGCGACGCTGGAGCGCCTGAAGGCCCTCGGCCACCAACTCGAGGTGATCGAGGACAGCTACCAGGATTT
CGGCGCCGGCCAGTTCATCTGGCGGATGGGCGATCCCGCCGTCGAGGGCTACGTGGCCGCGAGCGACCCGCGCCGCGACG
GGCAGGCCGTCGTCTGGTGA

Upstream 100 bases:

>100_bases
TCGTTGGCGGTCCTGCTCGGCCGCGCCTTCACCGACGCCGGATATCCTGTATGCCAGTGGCCGCGGGAGCGCGTGGGCTG
CCGAGGCTTGGAACAGTGCC

Downstream 100 bases:

>100_bases
CGCGCTACTTGACCTGCACGCTGTCCACCACTTGCCGGAACTTGGCGAGGACGCCGTCGCGCTGATCCTGCCGCACGACG
CCGAGGGCGCGGATGTAGCC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MKPFDWVTGYPSLRMPMFGRNCVATSHALAAQAGIQMLQAGGNAVDAAIATAAAKTVTEPCSNGLGSDAFCILWDGKALH
GLNASGGAPAAWSRDYFLNKYGAAERPPMRGWDSVTVPGAIAAWAALSERFGRLPFADLMQPAIRIAERGYLAPVVVQQK
WAAAARIEAITRQPGFSEFFLPRGRAPDVGELVTFPGAEKTLRLIGETKGEAFYRGEIAEAIAAHARANGGAMTAADLAA
FRPEWVTPTAKDYHGYTLHEIPPNGQGIAAQIALGLLEQFDLGGLPVDGPESQHLQIEAMKLAFSDTYRYVADPCGMEVT
PEAMLDPAYLAERAKLIDRNRAQVFGPGKPPAGGTIYLTAADESGMMVSFIQSNFMGFGSGVVVPGWGISLQNRGYGFVL
DAESPNVVAPGKRPFHTIIPGFLTKDGAPVMSFGVMGGNMQPQGHVQTLVRMIDHGQNPQSACDAPRWRVNEGLDINVEA
AMPGATLERLKALGHQLEVIEDSYQDFGAGQFIWRMGDPAVEGYVAASDPRRDGQAVVW

Sequences:

>Translated_539_residues
MKPFDWVTGYPSLRMPMFGRNCVATSHALAAQAGIQMLQAGGNAVDAAIATAAAKTVTEPCSNGLGSDAFCILWDGKALH
GLNASGGAPAAWSRDYFLNKYGAAERPPMRGWDSVTVPGAIAAWAALSERFGRLPFADLMQPAIRIAERGYLAPVVVQQK
WAAAARIEAITRQPGFSEFFLPRGRAPDVGELVTFPGAEKTLRLIGETKGEAFYRGEIAEAIAAHARANGGAMTAADLAA
FRPEWVTPTAKDYHGYTLHEIPPNGQGIAAQIALGLLEQFDLGGLPVDGPESQHLQIEAMKLAFSDTYRYVADPCGMEVT
PEAMLDPAYLAERAKLIDRNRAQVFGPGKPPAGGTIYLTAADESGMMVSFIQSNFMGFGSGVVVPGWGISLQNRGYGFVL
DAESPNVVAPGKRPFHTIIPGFLTKDGAPVMSFGVMGGNMQPQGHVQTLVRMIDHGQNPQSACDAPRWRVNEGLDINVEA
AMPGATLERLKALGHQLEVIEDSYQDFGAGQFIWRMGDPAVEGYVAASDPRRDGQAVVW
>Mature_539_residues
MKPFDWVTGYPSLRMPMFGRNCVATSHALAAQAGIQMLQAGGNAVDAAIATAAAKTVTEPCSNGLGSDAFCILWDGKALH
GLNASGGAPAAWSRDYFLNKYGAAERPPMRGWDSVTVPGAIAAWAALSERFGRLPFADLMQPAIRIAERGYLAPVVVQQK
WAAAARIEAITRQPGFSEFFLPRGRAPDVGELVTFPGAEKTLRLIGETKGEAFYRGEIAEAIAAHARANGGAMTAADLAA
FRPEWVTPTAKDYHGYTLHEIPPNGQGIAAQIALGLLEQFDLGGLPVDGPESQHLQIEAMKLAFSDTYRYVADPCGMEVT
PEAMLDPAYLAERAKLIDRNRAQVFGPGKPPAGGTIYLTAADESGMMVSFIQSNFMGFGSGVVVPGWGISLQNRGYGFVL
DAESPNVVAPGKRPFHTIIPGFLTKDGAPVMSFGVMGGNMQPQGHVQTLVRMIDHGQNPQSACDAPRWRVNEGLDINVEA
AMPGATLERLKALGHQLEVIEDSYQDFGAGQFIWRMGDPAVEGYVAASDPRRDGQAVVW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=549, Percent_Identity=26.5938069216758, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI73915090, Length=549, Percent_Identity=26.5938069216758, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI73915096, Length=549, Percent_Identity=26.5938069216758, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI73915094, Length=549, Percent_Identity=26.5938069216758, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI113429324, Length=553, Percent_Identity=27.3056057866184, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI113429326, Length=552, Percent_Identity=26.8115942028986, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI109148539, Length=547, Percent_Identity=25.4113345521024, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI153266885, Length=491, Percent_Identity=26.6802443991853, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI153266901, Length=495, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI153266907, Length=488, Percent_Identity=25.2049180327869, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789856, Length=533, Percent_Identity=30.0187617260788, Blast_Score=204, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI212646519, Length=522, Percent_Identity=24.7126436781609, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=522, Percent_Identity=24.7126436781609, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=567, Percent_Identity=25.0440917107584, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193208245, Length=534, Percent_Identity=25.2808988764045, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=534, Percent_Identity=25.2808988764045, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506189, Length=534, Percent_Identity=23.7827715355805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18859893, Length=516, Percent_Identity=25, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24642670, Length=533, Percent_Identity=24.953095684803, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642666, Length=533, Percent_Identity=24.953095684803, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077878, Length=533, Percent_Identity=24.953095684803, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077880, Length=533, Percent_Identity=24.953095684803, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45551474, Length=569, Percent_Identity=24.6045694200351, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077496, Length=559, Percent_Identity=25.4025044722719, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859741, Length=519, Percent_Identity=25.2408477842004, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57617; Mature: 57617

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFDWVTGYPSLRMPMFGRNCVATSHALAAQAGIQMLQAGGNAVDAAIATAAAKTVTEP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
CSNGLGSDAFCILWDGKALHGLNASGGAPAAWSRDYFLNKYGAAERPPMRGWDSVTVPGA
HHCCCCCCEEEEEECCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHH
IAAWAALSERFGRLPFADLMQPAIRIAERGYLAPVVVQQKWAAAARIEAITRQPGFSEFF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHC
LPRGRAPDVGELVTFPGAEKTLRLIGETKGEAFYRGEIAEAIAAHARANGGAMTAADLAA
CCCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
FRPEWVTPTAKDYHGYTLHEIPPNGQGIAAQIALGLLEQFDLGGLPVDGPESQHLQIEAM
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
KLAFSDTYRYVADPCGMEVTPEAMLDPAYLAERAKLIDRNRAQVFGPGKPPAGGTIYLTA
EEHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEE
ADESGMMVSFIQSNFMGFGSGVVVPGWGISLQNRGYGFVLDAESPNVVAPGKRPFHTIIP
CCCCCCCCEEHHHCCCCCCCCEEECCCCEEECCCCEEEEEECCCCCEECCCCCCHHHHCC
GFLTKDGAPVMSFGVMGGNMQPQGHVQTLVRMIDHGQNPQSACDAPRWRVNEGLDINVEA
HHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEECCCCCEEEEEC
AMPGATLERLKALGHQLEVIEDSYQDFGAGQFIWRMGDPAVEGYVAASDPRRDGQAVVW
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCEEECCCCCCCCCEECC
>Mature Secondary Structure
MKPFDWVTGYPSLRMPMFGRNCVATSHALAAQAGIQMLQAGGNAVDAAIATAAAKTVTEP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
CSNGLGSDAFCILWDGKALHGLNASGGAPAAWSRDYFLNKYGAAERPPMRGWDSVTVPGA
HHCCCCCCEEEEEECCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHH
IAAWAALSERFGRLPFADLMQPAIRIAERGYLAPVVVQQKWAAAARIEAITRQPGFSEFF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHC
LPRGRAPDVGELVTFPGAEKTLRLIGETKGEAFYRGEIAEAIAAHARANGGAMTAADLAA
CCCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
FRPEWVTPTAKDYHGYTLHEIPPNGQGIAAQIALGLLEQFDLGGLPVDGPESQHLQIEAM
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
KLAFSDTYRYVADPCGMEVTPEAMLDPAYLAERAKLIDRNRAQVFGPGKPPAGGTIYLTA
EEHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEE
ADESGMMVSFIQSNFMGFGSGVVVPGWGISLQNRGYGFVLDAESPNVVAPGKRPFHTIIP
CCCCCCCCEEHHHCCCCCCCCEEECCCCEEECCCCEEEEEECCCCCEECCCCCCHHHHCC
GFLTKDGAPVMSFGVMGGNMQPQGHVQTLVRMIDHGQNPQSACDAPRWRVNEGLDINVEA
HHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEECCCCCEEEEEC
AMPGATLERLKALGHQLEVIEDSYQDFGAGQFIWRMGDPAVEGYVAASDPRRDGQAVVW
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]