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The map label for this gene is obg

Identifier: 170746555

GI number: 170746555

Start: 111045

End: 112073

Strand: Reverse

Name: obg

Synonym: Mrad2831_0105

Alternate gene names: 170746555

Gene position: 112073-111045 (Counterclockwise)

Preceding gene: 170746556

Following gene: 170746554

Centisome position: 1.84

GC content: 68.8

Gene sequence:

>1029_bases
GTGAAGTTCCTCGACGAAGCCAAGGTCTATGTCCGCTCCGGTGATGGCGGTCCCGGCTGCGTCTCGTTCCGGCGCGAGAA
GTTCATCGAGTTCGGAGGACCGAACGGCGGCGACGGCGGCCGGGGCGGCGATGTCTGGGTGGAGTGCGTCGAGGGTCTCA
ACACCCTGATCGACTACCGATACCAGCAGCACTTCAAGGCGAAGAAGGGCGAGCACGGCATGGGCTCGAACTGCCACGGC
GCCAACGGCGCCGACACGGTCCTGAAGGTCCCGGCCGGCACGCAGATCTTCTCCGAAGACGGCGAGACGCTTCTCGCCGA
CCTGACCGAGGTCGGCCAGAAGATCCGTCTCGCGAAGGGCGGCAACGGCGGCTTCGGCAACGCCTACTTCACGACGTCCA
CCAATCGCGCCCCGAAGCACGCCAACCCCGGCCAGGAAGGCCAGGAGATGTGGATCTGGCTGCGGCTCAAGCTGATCGCC
GATGCCGGCCTCGTCGGCCTCCCGAATGCCGGAAAGTCGACCTTCCTGGCGAGCGTCACCGCGGCGAAGCCGAAGATCGC
CGACTACCCGTTCACGACCCTGCATCCCGGCCTCGGCGTGGTGCGGTCGGACGGGCGCGAGTTCGTGCTCGCCGACATCC
CGGGCCTGATCGAGGGTGCCCACGAGGGCGTCGGCCTCGGCGACAAGTTCCTCGCCCATGTCGAGCGCTGCCGGGTGCTG
CTGCACTTGGTGGACGGCACGAGCGAGCATGCCGGCAAGACCTACAAGCTGGTCCGCGGCGAGATCGAGGCCTACGGCAA
CGGCCTCGCGGAGAAGCCCGAGATCGTGGCGCTCTCGAAGGCCGACGCCCTCGACGCCGACACGCTCAAGAGCCAGGTGG
CGAAGCTGAAGCGCGCCGCCGGCCGCGCGCCGCTGATCCTGTCCTCGGCGAGCCGCAAGGGCGTACCCGAAGCGCTGCGG
GCGCTCCAAACCGAGATCGACGCCAGCGCCGAGGCCGAGCGGAAGCCGGTAGCCGCCTGGCAGCCGTAG

Upstream 100 bases:

>100_bases
GGGCCGCCTGAGGCGGTCCCGCGGCGCCGGGGCTGGCCGGCGGCCGCTCACAGGGTGATGGTGCGGGTCGCGAATCCGCG
CCCGACAAAGGATTCAGGTC

Downstream 100 bases:

>100_bases
CCCTCGACCGACTGTTCAAAGGGCGGCTCTTGGTTCACACCCGCCGTCGACGCGCCGTCCCGCAAGAATCATGATCCCTG
CCCTCGAAGAATTTCGCCGT

Product: GTP-binding protein Obg/CgtA

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKFLDEAKVYVRSGDGGPGCVSFRREKFIEFGGPNGGDGGRGGDVWVECVEGLNTLIDYRYQQHFKAKKGEHGMGSNCHG
ANGADTVLKVPAGTQIFSEDGETLLADLTEVGQKIRLAKGGNGGFGNAYFTTSTNRAPKHANPGQEGQEMWIWLRLKLIA
DAGLVGLPNAGKSTFLASVTAAKPKIADYPFTTLHPGLGVVRSDGREFVLADIPGLIEGAHEGVGLGDKFLAHVERCRVL
LHLVDGTSEHAGKTYKLVRGEIEAYGNGLAEKPEIVALSKADALDADTLKSQVAKLKRAAGRAPLILSSASRKGVPEALR
ALQTEIDASAEAERKPVAAWQP

Sequences:

>Translated_342_residues
MKFLDEAKVYVRSGDGGPGCVSFRREKFIEFGGPNGGDGGRGGDVWVECVEGLNTLIDYRYQQHFKAKKGEHGMGSNCHG
ANGADTVLKVPAGTQIFSEDGETLLADLTEVGQKIRLAKGGNGGFGNAYFTTSTNRAPKHANPGQEGQEMWIWLRLKLIA
DAGLVGLPNAGKSTFLASVTAAKPKIADYPFTTLHPGLGVVRSDGREFVLADIPGLIEGAHEGVGLGDKFLAHVERCRVL
LHLVDGTSEHAGKTYKLVRGEIEAYGNGLAEKPEIVALSKADALDADTLKSQVAKLKRAAGRAPLILSSASRKGVPEALR
ALQTEIDASAEAERKPVAAWQP
>Mature_342_residues
MKFLDEAKVYVRSGDGGPGCVSFRREKFIEFGGPNGGDGGRGGDVWVECVEGLNTLIDYRYQQHFKAKKGEHGMGSNCHG
ANGADTVLKVPAGTQIFSEDGETLLADLTEVGQKIRLAKGGNGGFGNAYFTTSTNRAPKHANPGQEGQEMWIWLRLKLIA
DAGLVGLPNAGKSTFLASVTAAKPKIADYPFTTLHPGLGVVRSDGREFVLADIPGLIEGAHEGVGLGDKFLAHVERCRVL
LHLVDGTSEHAGKTYKLVRGEIEAYGNGLAEKPEIVALSKADALDADTLKSQVAKLKRAAGRAPLILSSASRKGVPEALR
ALQTEIDASAEAERKPVAAWQP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=342, Percent_Identity=39.766081871345, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI111955139, Length=341, Percent_Identity=36.950146627566, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI111955063, Length=244, Percent_Identity=35.655737704918, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4758796, Length=151, Percent_Identity=35.0993377483444, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4557537, Length=117, Percent_Identity=36.7521367521368, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI58761500, Length=98, Percent_Identity=35.7142857142857, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789574, Length=336, Percent_Identity=49.1071428571429, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI1787454, Length=102, Percent_Identity=38.2352941176471, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=327, Percent_Identity=37.6146788990826, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17555344, Length=151, Percent_Identity=33.112582781457, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=114, Percent_Identity=36.8421052631579, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17509631, Length=99, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=180, Percent_Identity=37.2222222222222, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319281, Length=124, Percent_Identity=33.0645161290323, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321612, Length=118, Percent_Identity=38.135593220339, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129375, Length=301, Percent_Identity=39.5348837209302, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24585318, Length=336, Percent_Identity=37.202380952381, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17981711, Length=151, Percent_Identity=31.1258278145695, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=35.8974358974359, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_METRJ (B1M697)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001752815.1
- ProteinModelPortal:   B1M697
- SMR:   B1M697
- GeneID:   6136405
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_0105
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36327; Mature: 36327

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDEAKVYVRSGDGGPGCVSFRREKFIEFGGPNGGDGGRGGDVWVECVEGLNTLIDYR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAKKGEHGMGSNCHGANGADTVLKVPAGTQIFSEDGETLLADLTEVGQKIRLAKG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHEEEEEC
GNGGFGNAYFTTSTNRAPKHANPGQEGQEMWIWLRLKLIADAGLVGLPNAGKSTFLASVT
CCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCEEECCCCCCCCEEEEHH
AAKPKIADYPFTTLHPGLGVVRSDGREFVLADIPGLIEGAHEGVGLGDKFLAHVERCRVL
CCCCCCCCCCCHHCCCCCCEEECCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHH
LHLVDGTSEHAGKTYKLVRGEIEAYGNGLAEKPEIVALSKADALDADTLKSQVAKLKRAA
HHHHCCCCHHCCCEEEHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHC
GRAPLILSSASRKGVPEALRALQTEIDASAEAERKPVAAWQP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MKFLDEAKVYVRSGDGGPGCVSFRREKFIEFGGPNGGDGGRGGDVWVECVEGLNTLIDYR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAKKGEHGMGSNCHGANGADTVLKVPAGTQIFSEDGETLLADLTEVGQKIRLAKG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHEEEEEC
GNGGFGNAYFTTSTNRAPKHANPGQEGQEMWIWLRLKLIADAGLVGLPNAGKSTFLASVT
CCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCEEECCCCCCCCEEEEHH
AAKPKIADYPFTTLHPGLGVVRSDGREFVLADIPGLIEGAHEGVGLGDKFLAHVERCRVL
CCCCCCCCCCCHHCCCCCCEEECCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHH
LHLVDGTSEHAGKTYKLVRGEIEAYGNGLAEKPEIVALSKADALDADTLKSQVAKLKRAA
HHHHCCCCHHCCCEEEHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHC
GRAPLILSSASRKGVPEALRALQTEIDASAEAERKPVAAWQP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA