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The map label for this gene is lysR [H]

Identifier: 170746457

GI number: 170746457

Start: 7475

End: 8452

Strand: Reverse

Name: lysR [H]

Synonym: Mrad2831_0007

Alternate gene names: 170746457

Gene position: 8452-7475 (Counterclockwise)

Preceding gene: 170746460

Following gene: 170746455

Centisome position: 0.14

GC content: 74.54

Gene sequence:

>978_bases
ATGGCCGAGCGGCGCATGACCTTCCGGCACATCGAGGCGTTCCGGGCCGTGGTCGCCACCGGGTCGATGACCGAGGCGAG
CCGCCGGCTCCACACCTCGCAGCCGCAGGTCAGCCGGCTGATCGCCCAGCTGGAGACCATCACAGGCCTGCCCCTGTTCG
ATCGGAGCGGGAGCCGGGTCGTGCCCTCCCTCGACGGAACGCGGTTCCACGCGGAGGTCGAGCGCGCCTTCGTGGGTCTC
ACCAGCCTGGAATTCGCGGCCGCGCGGATCCGCGCCTTCGGGACGGAGCGGCTGCGGGTGGCCGCGATGCCGCGGCTGGC
GGGCGGGCTCCTCGCGCGGGCGGTCGTGCGTTTCCGCGCGGCGCATCCCGACGTGACCGTGGCGATCCATTCCGGCGACG
ACGAGACCGTGAACCACTGGCTCGCGACGGGCTCCTGCGACGCCGCGCTGACCATGCTGTACGGCGACGCTCCGGAGGCG
CGCGCCGAGCACGTCGAGACCCGGGCCTGCGTCGCCGTCCTGCCGCGCGACCATCCCCTCACCGCGCGGGCCGCGCTCGC
GCCCGCGGATTTTAACGGCGTACCGTTCGTCGCCGCTTCGCTCGGGAGCGCCCTGCGCGGCCGGACCGAGGCCATCTTCG
AGGCGGCCGGGATCGGCCTGACCATCACCGCCGAGGCCGGCCTCGGCGCCTCGATCTGCACGCTCGTCTCGGCCGGGCTC
GGGGTCAGCGTCATGAATCCGCTGGCGGCCCACGAGGAGGCGAAGGTCTCGCCGATCGCGATCCGGCCCTTCGCCCCCGC
GCTCCCCGTGCATTTCGCGCTGCTGTTCCCCCCGGATCACGCCCGGGGCCGCCTGATGCGGGCCTTCGGGGCCTGCGCGC
GGACGGTCCTGCTGGAGGAACTCGCCCAGCTACCGGACGCCGCGAGCGGGCGTCCGGCCGACGGTGCTCAGGCGGCGCGC
TTCTCGGCGCCGGCGTAG

Upstream 100 bases:

>100_bases
CCCCGACGGGGAGTCGGCCCGAAGCTTTGCCGGTCGATCCTAGGAGCGGCCGCGCGCGGGCGTCCAATGCCGATTCACCT
GCCGAGCATACGGATCTGAT

Downstream 100 bases:

>100_bases
AACGTGCCCCCGCGCTCGGCCATCGCGGCTAGGTTGTCGGGCACGTGGAAACGGGGCCCGTGCTTGGCCTCGAGCGACCG
CGCGAGGTCGACGAAGGCCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAERRMTFRHIEAFRAVVATGSMTEASRRLHTSQPQVSRLIAQLETITGLPLFDRSGSRVVPSLDGTRFHAEVERAFVGL
TSLEFAAARIRAFGTERLRVAAMPRLAGGLLARAVVRFRAAHPDVTVAIHSGDDETVNHWLATGSCDAALTMLYGDAPEA
RAEHVETRACVAVLPRDHPLTARAALAPADFNGVPFVAASLGSALRGRTEAIFEAAGIGLTITAEAGLGASICTLVSAGL
GVSVMNPLAAHEEAKVSPIAIRPFAPALPVHFALLFPPDHARGRLMRAFGACARTVLLEELAQLPDAASGRPADGAQAAR
FSAPA

Sequences:

>Translated_325_residues
MAERRMTFRHIEAFRAVVATGSMTEASRRLHTSQPQVSRLIAQLETITGLPLFDRSGSRVVPSLDGTRFHAEVERAFVGL
TSLEFAAARIRAFGTERLRVAAMPRLAGGLLARAVVRFRAAHPDVTVAIHSGDDETVNHWLATGSCDAALTMLYGDAPEA
RAEHVETRACVAVLPRDHPLTARAALAPADFNGVPFVAASLGSALRGRTEAIFEAAGIGLTITAEAGLGASICTLVSAGL
GVSVMNPLAAHEEAKVSPIAIRPFAPALPVHFALLFPPDHARGRLMRAFGACARTVLLEELAQLPDAASGRPADGAQAAR
FSAPA
>Mature_324_residues
AERRMTFRHIEAFRAVVATGSMTEASRRLHTSQPQVSRLIAQLETITGLPLFDRSGSRVVPSLDGTRFHAEVERAFVGLT
SLEFAAARIRAFGTERLRVAAMPRLAGGLLARAVVRFRAAHPDVTVAIHSGDDETVNHWLATGSCDAALTMLYGDAPEAR
AEHVETRACVAVLPRDHPLTARAALAPADFNGVPFVAASLGSALRGRTEAIFEAAGIGLTITAEAGLGASICTLVSAGLG
VSVMNPLAAHEEAKVSPIAIRPFAPALPVHFALLFPPDHARGRLMRAFGACARTVLLEELAQLPDAASGRPADGAQAARF
SAPA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=286, Percent_Identity=34.965034965035, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=27.7056277056277, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=28.6885245901639, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788748, Length=269, Percent_Identity=23.0483271375465, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787879, Length=299, Percent_Identity=27.4247491638796, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=218, Percent_Identity=23.8532110091743, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34243; Mature: 34111

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERRMTFRHIEAFRAVVATGSMTEASRRLHTSQPQVSRLIAQLETITGLPLFDRSGSRV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCEE
VPSLDGTRFHAEVERAFVGLTSLEFAAARIRAFGTERLRVAAMPRLAGGLLARAVVRFRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHC
AHPDVTVAIHSGDDETVNHWLATGSCDAALTMLYGDAPEARAEHVETRACVAVLPRDHPL
CCCCEEEEEECCCCHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHEEEECCCCCCC
TARAALAPADFNGVPFVAASLGSALRGRTEAIFEAAGIGLTITAEAGLGASICTLVSAGL
CHHHEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC
GVSVMNPLAAHEEAKVSPIAIRPFAPALPVHFALLFPPDHARGRLMRAFGACARTVLLEE
CHHHHCHHHHCCCCCCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LAQLPDAASGRPADGAQAARFSAPA
HHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AERRMTFRHIEAFRAVVATGSMTEASRRLHTSQPQVSRLIAQLETITGLPLFDRSGSRV
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCEE
VPSLDGTRFHAEVERAFVGLTSLEFAAARIRAFGTERLRVAAMPRLAGGLLARAVVRFRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHC
AHPDVTVAIHSGDDETVNHWLATGSCDAALTMLYGDAPEARAEHVETRACVAVLPRDHPL
CCCCEEEEEECCCCHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHEEEECCCCCCC
TARAALAPADFNGVPFVAASLGSALRGRTEAIFEAAGIGLTITAEAGLGASICTLVSAGL
CHHHEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC
GVSVMNPLAAHEEAKVSPIAIRPFAPALPVHFALLFPPDHARGRLMRAFGACARTVLLEE
CHHHHCHHHHCCCCCCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LAQLPDAASGRPADGAQAARFSAPA
HHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]