Click here to switch to the map view.

The map label for this gene is lolC

Identifier: 170683814

GI number: 170683814

Start: 2029884

End: 2031083

Strand: Reverse

Name: lolC

Synonym: EcSMS35_2010

Alternate gene names: 170683814

Gene position: 2031083-2029884 (Counterclockwise)

Preceding gene: 170680925

Following gene: 170679953

Centisome position: 40.07

GC content: 54.75

Gene sequence:

>1200_bases
ATGTACCAACCTGTCGCTCTATTTATTGGCCTGCGTTACATGCGTGGGCGTGCAGCGGATCGCTTCGGTCGTTTCGTCTC
CTGGCTTTCTACCATCGGCATTACCCTCGGGGTGATGGCGCTGGTCACAGTATTGTCAGTGATGAACGGCTTTGAGCGCG
AGCTGCAAAACAACATCCTTGGCCTGATGCCACAGGCAATTCTCTCTTCTGAGCATGGCTCTCTTAACCCGCAGCAACTC
CCGGAAACGGCAGTCAAACTGGACGGCGTTAATCGCGTCGCACCTATTACTACCGGTGATGTGGTACTGCAAAGCGCGCG
CAGCGTGGCGGTCGGGGTGATGCTGGGTATCGACCCGGCGCAAAAAGATCCACTAACGCCGTATCTGGTCAATGTGAAAC
AAACTGACCTCGAGCCGGGGAAATATAATGTCATCCTCGGTGAACAGCTTGCCTCACAGTTGGGCGTCAATCGCGGTGAT
CAAATCCGCGTGATGGTGCCATCTGCCAGCCAGTTCACGCCGATGGGGCGTATTCCAAGCCAGCGCCTGTTCAATGTGAT
TGGCACTTTCGCCGCCAACAGTGAAGTCGATGGCTATGAAATGCTGGTGAATATTGAGGATGCCTCGCGTCTGATGCGTT
ATCCGGCAGGCAATATTACCGGCTGGCGTTTGTGGCTGGATGAGCCGCTGAAAGTCGACTCATTAAGTCAGCAAAAACTG
CCTGAAGGCAGCAAATGGCAGGACTGGCGTGACCGTAAAGGCGAGCTTTTCCAGGCCGTACGCATGGAAAAAAATATGAT
GGGCTTACTGCTGAGCCTGATTGTCGCCGTTGCGGCGTTTAACATTATTACCTCGCTAGGGCTGATGGTGATGGAGAAGC
AGGGCGAAGTAGCGATCCTGCAAACGCAAGGCTTAACTCCGCGACAAATCATGATGGTCTTTATGGTGCAAGGGGCCAGC
GCTGGGATTATCGGTGCGATCCTCGGAGCGGCGCTTGGCGCACTGCTTGCCAGCCAGTTGAATAATCTGATGCCGATAAT
CGGCGTCCTGCTTGATGGCGCGGCGCTGCCGGTCGCTATCGAACCTTTACAGGTCATTGTTATTGCGCTGGTGGCGATGG
CTATCGCGCTGCTGTCTACGCTTTACCCTTCATGGCGCGCTGCCGCCACTCAACCCGCTGAGGCTTTACGTTATGAATAA

Upstream 100 bases:

>100_bases
TTTTCAGATTAGCCCTGACGATCACTTACAGTTCAGACGTTTACCCATCCCGCTTTCGCTTATATACTCGTGTCTTTGCT
ACAGCAACCAGACGGATTTC

Downstream 100 bases:

>100_bases
GATCCTGTTGCAATGCGACAACCTGTGCAAACGCTATCAGGAAGGCAGTGTGCAAACCGATGTACTGCACAATGTCAGTT
TCAGCGTCGGCGAAGGTGAA

Product: outer membrane-specific lipoprotein transporter subunit LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Sequences:

>Translated_399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
>Mature_399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily

Homologues:

Organism=Escherichia coli, GI1787360, Length=399, Percent_Identity=100, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1787362, Length=415, Percent_Identity=26.7469879518072, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LOLC_ECO57 (P0ADC5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85675
- PIR:   F90815
- RefSeq:   NP_287250.1
- RefSeq:   NP_309521.1
- ProteinModelPortal:   P0ADC5
- EnsemblBacteria:   EBESCT00000026939
- EnsemblBacteria:   EBESCT00000059823
- GeneID:   912675
- GeneID:   959470
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1757
- KEGG:   ecs:ECs1494
- GeneTree:   EBGT00050000008253
- HOGENOM:   HBG675801
- OMA:   RYPAANI
- ProtClustDB:   PRK10814
- BioCyc:   ECOL83334:ECS1494-MONOMER
- GO:   GO:0006810
- InterPro:   IPR003838
- InterPro:   IPR011925
- TIGRFAMs:   TIGR02212

Pfam domain/function: PF02687 FtsX

EC number: NA

Molecular weight: Translated: 43265; Mature: 43265

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a4cc868)-; HASH(0x1a0016dc)-; HASH(0x197b0a60)-; HASH(0x15a53544)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPS
CCCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH
QRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
HHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHCC
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
QTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAI
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
EPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCH
>Mature Secondary Structure
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPS
CCCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH
QRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
HHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHCC
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
QTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAI
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
EPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796