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The map label for this gene is umuC [H]

Identifier: 170683122

GI number: 170683122

Start: 1989260

End: 1990528

Strand: Reverse

Name: umuC [H]

Synonym: EcSMS35_1965

Alternate gene names: 170683122

Gene position: 1990528-1989260 (Counterclockwise)

Preceding gene: 170683779

Following gene: 170681324

Centisome position: 39.27

GC content: 50.67

Gene sequence:

>1269_bases
ATGTTTGCCCTCTGTGATGTAAACGCGTTTTATGCCAGCTGTGAGACGGTGTTTCGCCCTGATTTATGGGGTAAACCAGT
GGTTGTGCTATCGAATAATGACGGTTGCGTTATCGCCCGAAACGCTGAGGCAAAGGCGCTGGGTGTTAAAATGGGCGATC
CCTGGTTCAAACAAAAAGATCTGTTTCGTCGCTGTGGCGTGGTTTGCTTTAGCAGCAATTATGAGCTTTACGCAGACATG
AGCAATCGGGTGATGTCGACGCTGGAAGAACTATCGCCCCGCGTCGAGATTTACAGTATTGATGAGGCATTCTGCGATCT
GACCGGTGTGCGTAATTGTCGCGATCTGACTGATTTTGGCAGAGAAATTCGCGCAACGGTGCTACAACGTACCCATCTTA
CTGTTGGTGTGGGGATCGCCCAGACCAAAACGTTGGCTAAGCTTGCCAATCATGCGGCAAAAAAATGGCAGCGGCAGACG
GGTGGGGTGGTGGATTTATCAAATCTGGAACGCCAGCGTAAATTAATGTCTGCTCTCCCCGTGGATGAAGTCTGGGGGAT
TGGACGGCGGATCAGCAAAAAACTGGATGCGATGGGGATCAAAACCGTTCTCGATTTGGCGGATACAGATATCCGGTTTA
TCCGTAAACATTTTAATGTCGTGCTCGAAAGAACGGTGCGTGAACTGCGCGGCGAACCCTGTTTGCAACTGGAAGAGTTT
GCACCGACGAAGCAGGAAATTATCTGTTCCCGTTCGTTTGGTGAACGCATCACGGATTATACGTCGATGCGGCAGGCCAT
TTGTAGTTACGCTGCCCGGGCGGCGGAAAAACTTCGCAGCGAGCATCAATATTGTCGGTTTATCTCCACGTTTATTAAGA
CGTCACCATTTGCGCTCAATGAACCTTATTACGGCAATAGCGCGTCGGTAAAACTGCTGACGCCCACTCAGGACAGCAGG
GATATCATTAACGCCGCTACGCGATCTCTGGATGCCATCTGGCAAGCGGGCCATCGTTATCAAAAAGCGGGCGTGATGCT
GGGGGATTTCTTCAGTCAGGGAGTCGCGCAGCTCAATTTATTCGATGACAACGCACCGCGCCCCGGGAGTGAGCAATTGA
TGGCGGTAATGGATACGCTAAATGCTAAAGAGGGCAGAGGAACACTCTATTTTGCCGGGCAGGGGATCCAGCAACAATGG
CAGATGAAGCGTGCCATGCTTTCACCACGTTATACAACGCGAAGTTCTGATTTACTGCGGGTCAAATAA

Upstream 100 bases:

>100_bases
TTATTCCCATGAACAGTGCGTACTCGCCCATTACCATCAGTAGCGAAGATACGCTGGATGTCTTTGGTGTGGTGATCCAC
GTCGTTAAGGCGATGCGCTG

Downstream 100 bases:

>100_bases
ACATAGCGGCAGGAAAAAAGCGCTCCCGCAGGAGCGCTGAATGGATTAGCGACCGAACAGGTCACGTTTTTTCGCTTTAA
ACGGCTGGGAAATCACCACC

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADM
SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSR
DIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQW
QMKRAMLSPRYTTRSSDLLRVK

Sequences:

>Translated_422_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADM
SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSR
DIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQW
QMKRAMLSPRYTTRSSDLLRVK
>Mature_422_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADM
SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSR
DIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQW
QMKRAMLSPRYTTRSSDLLRVK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=99.2890995260664, Blast_Score=875, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=26.2672811059908, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47668; Mature: 47668

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCCHHHHH
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEECCCCEEEECHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
HHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
VDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
ECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEE
VK
CC
>Mature Secondary Structure
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCCHHHHH
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEECCCCEEEECHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
HHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
VDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
ECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEE
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]