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The map label for this gene is hicB [H]

Identifier: 170682851

GI number: 170682851

Start: 1741312

End: 1741749

Strand: Reverse

Name: hicB [H]

Synonym: EcSMS35_1736

Alternate gene names: 170682851

Gene position: 1741749-1741312 (Counterclockwise)

Preceding gene: 170680392

Following gene: 170682466

Centisome position: 34.36

GC content: 45.66

Gene sequence:

>438_bases
ATGCGAGAGACAGTCGAAATTATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGT
GGATATCCCTGAAGCGTTGACCCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCAT
TTGATTTTTATTTTGAAGATAACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCT
TTGAGCGTCGCCTCTAAAGTATTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAAT
TGGCAAACCTAAACAGGAGATTACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTA
AGGCGCTTGGCAAAGAGTTATCACTGGTGATGGTTTGA

Upstream 100 bases:

>100_bases
CATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAACAACTCGGTTTGAGTTAATCGC
CAATTAAAAAGGTTAATGAC

Downstream 100 bases:

>100_bases
TAACAGTTAATGAAAAGTTGTCATTTTTAACAACTGATATAGACTGCCGAATCACCTGCACATAATAACGATTCGATAAT
GAAAAAATACCAGCAGCTTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVP
LSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Sequences:

>Translated_145_residues
MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVP
LSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
>Mature_145_residues
MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVP
LSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Specific function: Part of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin preventing effects of the HicA toxin [H]

COG id: COG1598

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693129, Length=138, Percent_Identity=100, Blast_Score=281, Evalue=2e-77,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001387
- InterPro:   IPR005357 [H]

Pfam domain/function: PF01381 HTH_3; PF03681 UPF0150 [H]

EC number: NA

Molecular weight: Translated: 16106; Mature: 16106

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFED
CCCHHHHHHCCEEECCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHEECC
NELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNL
CCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
HHATKIDAVQLAAKALGKELSLVMV
HHHHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MRETVEIMRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFED
CCCHHHHHHCCEEECCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHEECC
NELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNL
CCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
HHATKIDAVQLAAKALGKELSLVMV
HHHHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]