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The map label for this gene is uhpB [H]

Identifier: 170679726

GI number: 170679726

Start: 4122073

End: 4123575

Strand: Reverse

Name: uhpB [H]

Synonym: EcSMS35_4033

Alternate gene names: 170679726

Gene position: 4123575-4122073 (Counterclockwise)

Preceding gene: 170684214

Following gene: 170679869

Centisome position: 81.36

GC content: 56.82

Gene sequence:

>1503_bases
ATGAAGACGTTTTTCTCTCGCTTAATTACCGTTATTGCCTGCTTTTTTATCTTCTCTGCCGCGTGGTTTTGCTTGTGGAG
TATCAGCCTGCACCTGGTTGAGCGCCCTGATATGGCGGTGCTGTTATTTCCGTTTGGTCTGCGTCTGGGGCTAATGCTGC
AATGCCCGCGCGGCTACTGGCCGGTGCTGCTGGGAGCGGAGTGGCTGCTGATTTACTGGCTAACGCAGGCGGTCGGTTTA
ACCCATTTCTCCTTATTGATGATCGGTAGTTTACTGACGTTATTGCCCGTGGCGCTTATCTCGCGCTATCGCCATCAACG
TGACTGGCGCACCCTGCTGTTACAGGGGGCAGCACTGACGGCGGCGGCGTTGTTGCAGTCGCTGCCCTGGCTTTGGCACG
GGAAAGAGTCGTGGAATGCGCTGTTGCTGACTTTAACTGGCGGCCTGACGCTGGCCCCGATATGTCTGGTGTTCTGGCAC
TATCTCGCCAATAACATCTGGCTGCCGCTCGGGCCGTCGTTAGTTTCTCAACCGATCAACTGGCGCGGGCGGCATCTGGT
CTGGTACTTGCTGCTGTTTGTTATCAGTCTCTGGCTCCAGTTGGGATTGCCGGACGAACTGTCGCGCTTTACGCCATTCT
GCCTGGCGCTGCCGATTATCGCGCTGGCCTGGCACTACGGCTGGCAAGGGGCGCTGATTGCGACGTTGATGAACGCCATC
GCGCTGATCGCCAGTCAAACCTGGCGCGATCATTCGGTGGATTTATTGCTCTCGCTGCTGGTGCAAAGTCTGACAGGGTT
GTTACTGGGCGCAGGCATCCAGCGGTTGCGTGAACTTAACCAGTCGCTGCAAAAGGAACTAGCGCGCAATCAGCATCTGG
CTGAACGTTTGTTAGAAACTGAAGAGAGCGTGCGCCGTGATGTGGCGCGTGAGCTGCACGACGATATCGGTCAGACCATC
ACTGCTATTCGTACTCAAGCAGGTATTGTTCAGCGGCTGGCGGCAGATAACGCCAGCGTGAAGCAGAGCGGGCAGCTCAT
CGAACACCTGTCGCTGGGTGTTTACGATGCGGTGCGCCGTTTGTTAGGGCGGTTACGTCCGCGCCAGCTGGATGATCTCA
CCCTGGAGCAGGCCATCCGCTCACTGATGCGGGAAATGGAGCTGGAAGGGCGCGGCATTGTCAGTCATCTCGAATGGCGA
ATCGATGAATCAGCGTTAAGCGAAAACCAGCGCGTGACGCTATTTCGCGTCTGCCAGGAAGGGTTGAACAACATTGTGAA
ACATGCCGATGCCAGCGCGGTCACGCTGCAAGGCTGGCAGCAGGATGAGCGGTTAATGCTGGTGATTGAAGACGATGGCA
GCGGTTTACCGCCAGATTCCGGGCAACACGGTTTTGGCCTTACCGGAATGCGCGAGCGCGTAACGGCGCTGGGCGGCACA
TTGACCATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAACGTTATGTCTAA

Upstream 100 bases:

>100_bases
TGTCACCGAAAACGGTACACGTCCATCGCGCTAACCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGAACTGGCGCGC
CGCATGTTTGATGGCTGGTG

Downstream 100 bases:

>100_bases
GGTTCGATGATGTTGCCGTTTCTGAAAGCGCCAGCTGACGCGCCGTTGATTAGCGATAAACAAGAAATTGATGCCCGTTA
CCGTTACTGGCGTCGGCATA

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKTFFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNIWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHSVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEHLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV

Sequences:

>Translated_500_residues
MKTFFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNIWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHSVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEHLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV
>Mature_500_residues
MKTFFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNIWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHSVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEHLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=500, Percent_Identity=98.4, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1788812, Length=214, Percent_Identity=30.8411214953271, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787474, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56373; Mature: 56373

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHEECCCCCC
PVLLGAEWLLIYWLTQAVGLTHFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNIWLPLGPSLVSQPIN
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWRDHSVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLET
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEHLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHH
GLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCLHGTRVSVSLPQRYV
EEEEEECCCEEEECCCCCCC
>Mature Secondary Structure
MKTFFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHEECCCCCC
PVLLGAEWLLIYWLTQAVGLTHFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNIWLPLGPSLVSQPIN
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWRDHSVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLET
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEHLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHH
GLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCLHGTRVSVSLPQRYV
EEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]