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The map label for this gene is thiC

Identifier: 170077453

GI number: 170077453

Start: 858725

End: 860110

Strand: Reverse

Name: thiC

Synonym: SYNPCC7002_A0831

Alternate gene names: 170077453

Gene position: 860110-858725 (Counterclockwise)

Preceding gene: 170077456

Following gene: 170077452

Centisome position: 28.59

GC content: 52.31

Gene sequence:

>1386_bases
ATGAGAGCTGATTGGGTCGCCAAACGGCAAGGTCAAAGTAACGTCTCCCAAATGCACTACGCACGCCAAGGCGTTATCAC
CGAAGAAATGGACTACGTGGCAAAGCGTGAGAATCTGCCCGTTGACTTGATTCGCGACGAAGTAGCCCGGGGTCGCATGA
TTATCCCGGCTAATATCAATCACACCAACCTCGAACCGATGTGTATCGGCATTGCTTCGAAATGCAAAGTCAATGCAAAT
ATCGGTGCGTCCCCCAACTCCTCTGAAATTAATGAGGAATTGGCTAAGCTACAACAGGCCGTTAAATATGGTGCGGATAC
TGTGATGGATCTCTCCACTGGGGGCGGCAACCTGGACGAAATTCGTACTGCCATTATCAAAGCCTCACCGGTGCCCATCG
GGACTGTGCCCATTTACCAAGCCCTAGAAAGTGTCCATGGCAACATGGAAAACCTCACGGCCAATGATTTCTTGCACATC
ATCGAGAAGCACGCCCAGCAAGGGGTGGACTACATGACCATCCACGCCGGGATCTTGATCGAGCATCTGCCCCTTGTGAA
AAACCGGATTACGGGGATTGTGTCCCGTGGTGGTGGAATCCTTGCCCGTTGGATGTTGCATCACCATAAGCAAAATCCCC
TCTACACCCACTTTGACGACATTATCGAAATCTTTAAGCGCTACGATGTGTCCTTCAGCCTTGGGGATTCTCTGCGTCCT
GGCTGTACCCACGATGCTTCTGATGAGGCGCAACTCGCTGAACTGAAAACCCTAGGTCAACTGACCCGTCGCGCTTGGGA
ACACGATGTCCAAGTGATGGTAGAAGGCCCTGGCCACGTCCCCATGGATCAGATCGAGTTCAACGTGAAGAAGCAGATGG
AAGAGTGCTCTGAAGCACCTTTCTATGTGCTCGGCCCCTTGGTGACTGATATTGCGCCTGGCTATGACCACATCACCTCG
GCGATCGGGGCGGCGATGGCTGGCTGGTACGGCACGGCAATGCTCTGCTATGTCACCCCCAAAGAGCACCTCGGCCTACC
TGATGCGGAGGATGTGCGGAATGGTCTCATCGCCTATAAGATTGCGGCCCATGCGGCAGATATTGCCCGTCATCGTCCTG
GGGCACGCGATCGCGATGATGAGTTGTCCCATGCTCGGTATAACTTTGATTGGGAGAAACAGTTTGAACTGTCCCTCGAT
CCTGAGCGTGCTCGTGAATACCACGATGAAACTCTTCCCGCAGATATCTACAAAACAGCAGAATTCTGCTCGATGTGTGG
CCCTAAATTCTGTCCGATGCAAACGAAAGTTGATGCGGATGCGTTAACGGAACTGGAAAAGTATTTAGCTAGTACTGCCG
CCAAGGAAGAACTCGCCAAAGCTTAA

Upstream 100 bases:

>100_bases
TAGGGGTGTCTGTCATAGGAATCAGACTGAGATAGTCCCTTAGAACCTGAGACTGGGTAATACCAGCGTAGGGAAGCTGT
TAATAGAGGATTAAAACAAT

Downstream 100 bases:

>100_bases
GCCTTATTTATGGGGTGTGTTATTACAAAATAATGCACTCTATACTCACGTTTTCTGCATGAAATTCACACAATATTTTT
TAACGACGAGACAACGTCCG

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANINHTNLEPMCIGIASKCKVNAN
IGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDEIRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHI
IEKHAQQGVDYMTIHAGILIEHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRP
GCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITS
AIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLD
PERAREYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA

Sequences:

>Translated_461_residues
MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANINHTNLEPMCIGIASKCKVNAN
IGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDEIRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHI
IEKHAQQGVDYMTIHAGILIEHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRP
GCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITS
AIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLD
PERAREYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA
>Mature_461_residues
MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANINHTNLEPMCIGIASKCKVNAN
IGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDEIRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHI
IEKHAQQGVDYMTIHAGILIEHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRP
GCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITS
AIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLD
PERAREYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family

Homologues:

Organism=Escherichia coli, GI1790427, Length=447, Percent_Identity=59.2841163310962, Blast_Score=545, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THIC_SYNP2 (B1XIG4)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734091.1
- GeneID:   6057587
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0831
- HOGENOM:   HBG285234
- OMA:   EPMAIGI
- ProtClustDB:   PRK13352
- HAMAP:   MF_00089
- InterPro:   IPR002817
- TIGRFAMs:   TIGR00190

Pfam domain/function: PF01964 ThiC

EC number: NA

Molecular weight: Translated: 51298; Mature: 51298

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: BINDING 80-80 BINDING 109-109 BINDING 139-139 BINDING 175-175 BINDING 275-275 BINDING 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANIN
CCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCC
HTNLEPMCIGIASKCKVNANIGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDE
CCCCCHHEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
IRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHIIEKHAQQGVDYMTIHAGILI
HHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHH
EHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCCCC
GCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
FYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYK
EEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCHHHHHCCHHHHH
IAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLDPERAREYHDETLPADIYKTA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHH
EFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANIN
CCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCC
HTNLEPMCIGIASKCKVNANIGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDE
CCCCCHHEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
IRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHIIEKHAQQGVDYMTIHAGILI
HHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHH
EHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCCCC
GCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
FYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYK
EEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCHHHHHCCHHHHH
IAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLDPERAREYHDETLPADIYKTA
HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHH
EFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA