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The map label for this gene is atpB

Identifier: 170026424

GI number: 170026424

Start: 4659293

End: 4660117

Strand: Direct

Name: atpB

Synonym: YPK_4220

Alternate gene names: 170026424

Gene position: 4659293-4660117 (Clockwise)

Preceding gene: 170026423

Following gene: 170026425

Centisome position: 99.36

GC content: 46.06

Gene sequence:

>825_bases
ATGTCTGCATCAGGAGAAATCTCTACTCCAAGGGACTACATAGGTCACCACCTGAATCACCTTCAGTTGGACCTGCGTAC
CTTTGAGTTGGTCAATCCCCACTCAACTGGCCCTGCAACGTTCTGGACGTTGAACATTGACTCTTTGTTCTTCTCTGTCG
TGCTGGGGTTAGCTTTTCTGCTTGTGTTCCGCAAAGTTGCTGCAAGCGCCACCAGTGGCGTACCCGGTAAATTGCAGACT
GCTGTAGAGTTAATTATCGGTTTTGTCGATAACAGTGTGCGGGATATGTATCACGGCAAAAGTAAAGTCATCGCACCATT
AGCCCTAACAGTCTTTGTTTGGGTTTTATTGATGAACATGATGGATTTACTGCCAATCGATTTACTGCCTTACATCGGTG
AACATGTCTTTGGGTTACCAGCACTGCGTGTGGTACCTACAGCTGACGTGAGCATTACGTTGTCTATGGCATTGGGTGTT
TTCATCCTGATTATTTTCTATAGCATTAAAATGAAAGGTGTAGGCGGCTTCACAAAAGAATTAACTATGCAGCCGTTCAA
TCACCCGATATTCATTCCAGTAAACTTAATTCTGGAAGGTGTCAGCCTGCTGTCCAAACCGCTTTCATTGGGTCTGCGAC
TGTTCGGCAACATGTATGCGGGTGAGTTGATCTTCATCCTGATTGCGGGTCTGTTGCCGTGGTGGTCACAGTGGATGCTC
AGTGTTCCTTGGGCTATATTCCACATCCTGATCATTACGTTACAAGCCTTTATCTTCATGGTTCTGACGATTGTCTATCT
CTCGATGGCATCCGAAGAGCACTGA

Upstream 100 bases:

>100_bases
GTGCAGATTTTAGCACCGGCCGTGATTAACGGTCACCGTACTTAACAGTTATCGTATTTAACAGTTATCGTATTTAACTA
CAACAAGGGTAAGAGGCATC

Downstream 100 bases:

>100_bases
TTTTCTTATAACACTACTGCGTTTTAACTGAAATAAACTGGAGACTGTCATGGAAAACCTGAATATGGATCTGCTGTACA
TGGCTGCCGCTGTGATGATG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQT
AVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGV
FILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Sequences:

>Translated_274_residues
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQT
AVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGV
FILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
>Mature_273_residues
SASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQTA
VELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVF
ILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWMLS
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=271, Percent_Identity=84.1328413284133, Blast_Score=446, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_YERP3 (A7FPE6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001403124.1
- ProteinModelPortal:   A7FPE6
- STRING:   A7FPE6
- GeneID:   5388386
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_4182
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   LPWWSQF
- ProtClustDB:   PRK05815
- BioCyc:   YPSE349747:YPSIP31758_4182-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30412; Mature: 30281

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x180df590)-; HASH(0x1b9beeb8)-; HASH(0x1b179034)-; HASH(0x1c0b4968)-; HASH(0x1c12bdac)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHH
LVFRKVAASATSGVPGKLQTAVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVFILIIFYSIKMKGVGGFTKE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHH
LVFRKVAASATSGVPGKLQTAVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVFILIIFYSIKMKGVGGFTKE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA