Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 170026383

GI number: 170026383

Start: 4604716

End: 4605339

Strand: Direct

Name: gmk

Synonym: YPK_4176

Alternate gene names: 170026383

Gene position: 4604716-4605339 (Clockwise)

Preceding gene: 170026381

Following gene: 170026384

Centisome position: 98.19

GC content: 46.47

Gene sequence:

>624_bases
ATGGTTCAAGGTACGCTATACATAGTTTCCGCGCCCAGCGGGGCAGGGAAATCAAGCCTGATTCAGGCTTTGTTAAAAAC
ACAACCGCTGTACGACACGCAGGTTTCAATTTCCCATACCACGCGTGCTAAACGTCCAGGGGAGAATCACGGCGAGCATT
ACTTCTTTGTTTCTGAAAAAGAGTTTTGCCAGATGATTGATGATGATGCTTTTCTTGAGCATGCCAAAGTATTTGAAAAT
TACTACGGTACCTCACGTCTGGCTATTGAGCAGGTTCTTGCAACCGGGGTTGATGTCTTTTTAGATATTGACTGGCAAGG
AGCGCAACAGATTCGCGCAAAAATGCCAACCGCTCGCAGTATTTTCATCTTGCCGCCATCCAAAACAGAATTGGATCGCC
GTTTACGCGGTCGTGGGCAGGATAGCGAAGAAGTTATCGCTAAGCGTATGGAGCAAGCTGTCGCAGAGATGGCCCATTAC
GCAGAGTATGATTATTTAATCGTAAATGATGATTTCAATCTGGCTTTGTCTGATCTGAAAACCATTATTCGCGCAGAACG
ACTGCGTTTAGGCCGCCAGAAACAGCGGCATGACGCTTTAATCAGCAAATTATTGGCGGACTGA

Upstream 100 bases:

>100_bases
GGTGAGTTGGCTAGAGCCAGTCATTCGAGAAAGAGCTGCTAACACTGCTGCAACCTCAAGGTAAGAAGGGTATATCAACC
TAATCAACTGAAACGTCATC

Downstream 100 bases:

>100_bases
ACAGAGTTTCAGTATCATGCCCAGTCATTTCGTCACCTGTGGAGTAGCAGAATTATGGCACGCGTAACTGTTCAAGACGC
TGTAGAGAAAATTGGTAACC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MVQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSISHTTRAKRPGENHGEHYFFVSEKEFCQMIDDDAFLEHAKVFEN
YYGTSRLAIEQVLATGVDVFLDIDWQGAQQIRAKMPTARSIFILPPSKTELDRRLRGRGQDSEEVIAKRMEQAVAEMAHY
AEYDYLIVNDDFNLALSDLKTIIRAERLRLGRQKQRHDALISKLLAD

Sequences:

>Translated_207_residues
MVQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSISHTTRAKRPGENHGEHYFFVSEKEFCQMIDDDAFLEHAKVFEN
YYGTSRLAIEQVLATGVDVFLDIDWQGAQQIRAKMPTARSIFILPPSKTELDRRLRGRGQDSEEVIAKRMEQAVAEMAHY
AEYDYLIVNDDFNLALSDLKTIIRAERLRLGRQKQRHDALISKLLAD
>Mature_207_residues
MVQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSISHTTRAKRPGENHGEHYFFVSEKEFCQMIDDDAFLEHAKVFEN
YYGTSRLAIEQVLATGVDVFLDIDWQGAQQIRAKMPTARSIFILPPSKTELDRRLRGRGQDSEEVIAKRMEQAVAEMAHY
AEYDYLIVNDDFNLALSDLKTIIRAERLRLGRQKQRHDALISKLLAD

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=38.2513661202186, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=38.2513661202186, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=38.2513661202186, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=31.7919075144509, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=32.6086956521739, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=27.319587628866, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI21536464, Length=187, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=87.9227053140097, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=35.9116022099448, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=35.9116022099448, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=44.6236559139785, Blast_Score=143, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.9120879120879, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=28.735632183908, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=28.735632183908, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=29.608938547486, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_YERPA (Q1C258)

Other databases:

- EMBL:   CP000308
- RefSeq:   YP_653409.1
- ProteinModelPortal:   Q1C258
- SMR:   Q1C258
- STRING:   Q1C258
- GeneID:   4119628
- GenomeReviews:   CP000308_GR
- KEGG:   ypa:YPA_3502
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   YPES360102:YPA_3502-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23504; Mature: 23504

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSISHTTRAKRPGENHGEHYFFVSEK
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCEEEEECHH
EFCQMIDDDAFLEHAKVFENYYGTSRLAIEQVLATGVDVFLDIDWQGAQQIRAKMPTARS
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCE
IFILPPSKTELDRRLRGRGQDSEEVIAKRMEQAVAEMAHYAEYDYLIVNDDFNLALSDLK
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHH
TIIRAERLRLGRQKQRHDALISKLLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSISHTTRAKRPGENHGEHYFFVSEK
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCCCEEEEECHH
EFCQMIDDDAFLEHAKVFENYYGTSRLAIEQVLATGVDVFLDIDWQGAQQIRAKMPTARS
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCE
IFILPPSKTELDRRLRGRGQDSEEVIAKRMEQAVAEMAHYAEYDYLIVNDDFNLALSDLK
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHH
TIIRAERLRLGRQKQRHDALISKLLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA