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The map label for this gene is gpsA

Identifier: 170026344

GI number: 170026344

Start: 4569526

End: 4570545

Strand: Reverse

Name: gpsA

Synonym: YPK_4137

Alternate gene names: 170026344

Gene position: 4570545-4569526 (Counterclockwise)

Preceding gene: 170026345

Following gene: 170026343

Centisome position: 97.46

GC content: 51.57

Gene sequence:

>1020_bases
ATGAACACCAACCCTGCTTCAATGGCTGTTATCGGTGCCGGATCTTACGGCACCGCATTAGCTATCACACTGGCGCGTAA
TGGCCATCAAGTCGTGTTATGGGGCCATGACCCTAAACATATTCAACAGCTGCAACAAGACCGCTGTAACCGCGCTTTCC
TACCTGATGCTGCTTTCCCCGATACGTTGCGATTGGAAACCGACTTAGCATGTGCGTTGGCTGCCAGCCGCGATGTGTTG
GTCGTCGTGCCCAGCCATGTCTTTGGTGCTGTTTTACATCAGTTGAAGCCTCATCTACGTAAAGATGCACGTATCGTCTG
GGCAACCAAAGGGCTAGAAGCTGAAACCGGCCGTCTGCTACAGGATGTGGCCCGCGAAGTCTTGGGCGAGGCTATCCCGC
TTGCCGTGATTTCTGGTCCAACGTTTGCCAAAGAATTGGCCGCGGGTTTGCCTACGGCGATTGCGTTGGCATCGACCGAT
GTGCAATTTAGCGAAGATCTGCAACAGTTATTGCACTGTGGAAAAAGCTTTCGAGTTTACAGTAATCCTGATTTTATCGG
GGTACAGCTTGGTGGCGCAGTGAAAAACGTGATTGCCATCGGTGCAGGTATGTCCGATGGCATCGGTTTTGGTGCGAATG
CCCGTACCGCTCTAATAACCCGCGGGTTAGCGGAGATGACGCGCTTAGGGACGGCATTAGGTGCCGATCCTTCCACCTTT
ATGGGCATGGCAGGGTTAGGCGATTTGGTGCTAACCTGCACAGATAACCAATCCCGTAACCGCCGATTTGGCATTATGCT
GGGTCAGGGGTTGGGGGTGAAGGAGGCGCAGGACAACATTGGTCAAGTGGTAGAAGGTTACCGTAATACCAAGGAAGTTC
TGGCATTAGCACAGCGTCATGGCGTCGAAATGCCAATAACTGAACAAATTTATCAAGTGTTGTATTGTCATAAGAATGCT
CGTGAGGCGGCTCTGACGTTGTTGGGGCGGACCAAAAAAGATGAAAAAATCGGCATTTGA

Upstream 100 bases:

>100_bases
TGAATTTGGCACCTGTTAACTTTGATGCTCTGTTCATGAATTATCTGCAACAGCAGGCTGAAGGTGAAGTTGAAGGTGTT
GAACAACGTCAGGATGCCTG

Downstream 100 bases:

>100_bases
TAGATTAGAAGAGTAGGTCAGCTAGCTGAAATAAAATAATCGCTACGTGCCCAACGTCATTGGAGTTGCAGCAAGGCAGC
AAACGAGCCTATCCCGATGA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFPDTLRLETDLACALAASRDVL
VVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLLQDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTD
VQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTF
MGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKNA
REAALTLLGRTKKDEKIGI

Sequences:

>Translated_339_residues
MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFPDTLRLETDLACALAASRDVL
VVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLLQDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTD
VQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTF
MGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKNA
REAALTLLGRTKKDEKIGI
>Mature_339_residues
MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFPDTLRLETDLACALAASRDVL
VVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLLQDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTD
VQFSEDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTF
MGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKNA
REAALTLLGRTKKDEKIGI

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=333, Percent_Identity=27.9279279279279, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI24307999, Length=344, Percent_Identity=25.5813953488372, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1790037, Length=336, Percent_Identity=84.5238095238095, Blast_Score=586, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17507425, Length=354, Percent_Identity=23.728813559322, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI32564399, Length=334, Percent_Identity=24.8502994011976, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32564403, Length=345, Percent_Identity=24.0579710144928, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193210136, Length=345, Percent_Identity=24.0579710144928, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193210134, Length=204, Percent_Identity=27.9411764705882, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320181, Length=344, Percent_Identity=27.6162790697674, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324513, Length=345, Percent_Identity=26.0869565217391, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136202, Length=330, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136204, Length=330, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136200, Length=330, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22026922, Length=271, Percent_Identity=22.8782287822878, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551945, Length=237, Percent_Identity=29.535864978903, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281362270, Length=237, Percent_Identity=29.535864978903, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24648969, Length=184, Percent_Identity=32.0652173913043, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_YERP3 (A7FCV2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001399080.1
- ProteinModelPortal:   A7FCV2
- SMR:   A7FCV2
- STRING:   A7FCV2
- GeneID:   5388456
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_0079
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   YPSE349747:YPSIP31758_0079-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36194; Mature: 36194

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 195-195 BINDING 110-110 BINDING 110-110 BINDING 143-143 BINDING 259-259 BINDING 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFP
CCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
DTLRLETDLACALAASRDVLVVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLL
CCEEECHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
QDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTDVQFSEDLQQLLHCGKSFRVY
HHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEE
SNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTF
CCCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
MGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRH
HHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GVEMPITEQIYQVLYCHKNAREAALTLLGRTKKDEKIGI
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNTNPASMAVIGAGSYGTALAITLARNGHQVVLWGHDPKHIQQLQQDRCNRAFLPDAAFP
CCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
DTLRLETDLACALAASRDVLVVVPSHVFGAVLHQLKPHLRKDARIVWATKGLEAETGRLL
CCEEECHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
QDVAREVLGEAIPLAVISGPTFAKELAAGLPTAIALASTDVQFSEDLQQLLHCGKSFRVY
HHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEE
SNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMTRLGTALGADPSTF
CCCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
MGMAGLGDLVLTCTDNQSRNRRFGIMLGQGLGVKEAQDNIGQVVEGYRNTKEVLALAQRH
HHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GVEMPITEQIYQVLYCHKNAREAALTLLGRTKKDEKIGI
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA