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The map label for this gene is cpxA [H]

Identifier: 170026340

GI number: 170026340

Start: 4565150

End: 4566526

Strand: Direct

Name: cpxA [H]

Synonym: YPK_4133

Alternate gene names: 170026340

Gene position: 4565150-4566526 (Clockwise)

Preceding gene: 170026339

Following gene: 170026342

Centisome position: 97.35

GC content: 49.82

Gene sequence:

>1377_bases
ATGATAAACAGTTTAACGACGCGAATTTTTGCTATTTTCTGGTTTACTTTAGCGTTAGTGCTCATGCTAGTGCTGATGGT
GCCAAAGCTTGATTCGCGTCAACTCACTGTTTTACTCGACAGTGAACAGCGTCAGGGAACGATGCTGGAACAACATATTG
AAGCTGAACTGGCCAATGATCCTGCCAATGACCTCATGTGGTGGCGTAGGCTACACCGCGCCATTGAGAAATGGGCTCCG
CCTGGGCAACATTTGATTTTGGTGACGTCTGAGGGCCGTATCATTGGCGTACAGCGTCAAGAAGTGCAAATGGTGCGTAA
CTTTATCGGCCAATCGGATAACGCCGATCAGCCGAAAAAGAAAAAGTATGGCCGGGTAGAAATGGTCGGTCCCTTTTCCA
TCAGGGACGGCGAAGATAACTATCAGCTTTATCTAATACGCCCCGCCAATAGTCCGCAATCTGATTTTATTAATCTGATG
TTTGACCGCCCGCTGCTGCTCTTGATTGCGACCATGTTGATCAGTGCACCGCTGCTACTTTGGTTGGCATGGAGCCTGGC
GAAACCTGCCCGCAAGCTGAAAAATGCGGCTGATGATGTGGCCCGAGGTAACCTGAAACAACATCCTGAATTGGAATCCG
GTCCACAGGAATTTTTAGCCACAGGTGCCAGTTTCAACCAGATGATCAGTTCGTTAGACAGAATGGTCGTCGCTCAACAA
CGGCTGATTTCAGATATTTCCCATGAGTTACGCACACCACTTACCCGGCTGCAACTGGCCACCGCGCTGATGCGCCGCCG
TCATGGTGAAGGGAAAGAATTAGAGCGTATCGAAATGGAAGCACAGCGCTTAGATAGCATGATTAATGACTTGCTGGTGT
TATCGCGTAGCCAGCATAAAAATGAATTACACCGCGAACCCATTAAAGCTGATGAGCTTTGGTCCGATGTGCTGGAGAAT
GCACAGTTCGAGGCTGAACAAATGGGTAAAACGCTGGTAGTCACGGCACCTCCGGGGCCATGGCCCTTATTTTGTAATCC
TGCGGCCCTTGACAGTGCGCTGGAGAATATCGTGCGTAACGCACTGCGTTACTCCCATCATCATATTGCGGTGGCATTCA
GCATAGATAATCAAGGCGTCACTATCATTGTTGATGATGATGGTCCAGGCGTCAGCCCAGAGGACCGTGAACAAATATTC
CGGCCATTTTATCGTACTGATGAAGCCCGAGATCGGGCGTCGGGAGGAACAGGATTGGGCCTGGCAATTGTTGAAACCGC
GGTGAGTCAGCATCGAGGGTGGGTAAAAGCCGAAGATAGCCCATTAGGTGGCTTACGCCTGATTGTCTGGCTACCGCTGC
ATCCGCTTAAATCTTAA

Upstream 100 bases:

>100_bases
TGCACATCTCGAACTTACGCCGTAAGTTACCAGACCGCAAAGACGGGCTACCGTGGTTTAAAACGTTGCGTGGCCGCGGC
TACTTGATGGTATCAGAAAC

Downstream 100 bases:

>100_bases
TCTGCCGTCTATCTGCCCGATCAATGTGGTTCGGGCAGATATTGAGAATCAGTGGTCTTCCGCCTCTTTTTCCACACTCT
CTCTTTCCAGCAAAAGCCTC

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MINSLTTRIFAIFWFTLALVLMLVLMVPKLDSRQLTVLLDSEQRQGTMLEQHIEAELANDPANDLMWWRRLHRAIEKWAP
PGQHLILVTSEGRIIGVQRQEVQMVRNFIGQSDNADQPKKKKYGRVEMVGPFSIRDGEDNYQLYLIRPANSPQSDFINLM
FDRPLLLLIATMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELESGPQEFLATGASFNQMISSLDRMVVAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEGKELERIEMEAQRLDSMINDLLVLSRSQHKNELHREPIKADELWSDVLEN
AQFEAEQMGKTLVVTAPPGPWPLFCNPAALDSALENIVRNALRYSHHHIAVAFSIDNQGVTIIVDDDGPGVSPEDREQIF
RPFYRTDEARDRASGGTGLGLAIVETAVSQHRGWVKAEDSPLGGLRLIVWLPLHPLKS

Sequences:

>Translated_458_residues
MINSLTTRIFAIFWFTLALVLMLVLMVPKLDSRQLTVLLDSEQRQGTMLEQHIEAELANDPANDLMWWRRLHRAIEKWAP
PGQHLILVTSEGRIIGVQRQEVQMVRNFIGQSDNADQPKKKKYGRVEMVGPFSIRDGEDNYQLYLIRPANSPQSDFINLM
FDRPLLLLIATMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELESGPQEFLATGASFNQMISSLDRMVVAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEGKELERIEMEAQRLDSMINDLLVLSRSQHKNELHREPIKADELWSDVLEN
AQFEAEQMGKTLVVTAPPGPWPLFCNPAALDSALENIVRNALRYSHHHIAVAFSIDNQGVTIIVDDDGPGVSPEDREQIF
RPFYRTDEARDRASGGTGLGLAIVETAVSQHRGWVKAEDSPLGGLRLIVWLPLHPLKS
>Mature_458_residues
MINSLTTRIFAIFWFTLALVLMLVLMVPKLDSRQLTVLLDSEQRQGTMLEQHIEAELANDPANDLMWWRRLHRAIEKWAP
PGQHLILVTSEGRIIGVQRQEVQMVRNFIGQSDNADQPKKKKYGRVEMVGPFSIRDGEDNYQLYLIRPANSPQSDFINLM
FDRPLLLLIATMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELESGPQEFLATGASFNQMISSLDRMVVAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEGKELERIEMEAQRLDSMINDLLVLSRSQHKNELHREPIKADELWSDVLEN
AQFEAEQMGKTLVVTAPPGPWPLFCNPAALDSALENIVRNALRYSHHHIAVAFSIDNQGVTIIVDDDGPGVSPEDREQIF
RPFYRTDEARDRASGGTGLGLAIVETAVSQHRGWVKAEDSPLGGLRLIVWLPLHPLKS

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=454, Percent_Identity=80.8370044052863, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=322, Percent_Identity=33.8509316770186, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789808, Length=274, Percent_Identity=31.021897810219, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786783, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=31.6017316017316, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=29.1970802919708, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=29.3333333333333, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=25.6666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=238, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=24.6861924686192, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=331, Percent_Identity=24.773413897281, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=23.4432234432234, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790861, Length=287, Percent_Identity=24.7386759581882, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=278, Percent_Identity=23.021582733813, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=26.4840182648402, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=24.5762711864407, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=26.8722466960352, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51824; Mature: 51824

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSLTTRIFAIFWFTLALVLMLVLMVPKLDSRQLTVLLDSEQRQGTMLEQHIEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
PANDLMWWRRLHRAIEKWAPPGQHLILVTSEGRIIGVQRQEVQMVRNFIGQSDNADQPKK
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVEMVGPFSIRDGEDNYQLYLIRPANSPQSDFINLMFDRPLLLLIATMLISAPLLL
HHCCCEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADDVARGNLKQHPELESGPQEFLATGASFNQMISSLDRMVVAQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLISDISHELRTPLTRLQLATALMRRRHGEGKELERIEMEAQRLDSMINDLLVLSRSQHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELHREPIKADELWSDVLENAQFEAEQMGKTLVVTAPPGPWPLFCNPAALDSALENIVRN
HHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
ALRYSHHHIAVAFSIDNQGVTIIVDDDGPGVSPEDREQIFRPFYRTDEARDRASGGTGLG
HHHHCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCHH
LAIVETAVSQHRGWVKAEDSPLGGLRLIVWLPLHPLKS
HHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MINSLTTRIFAIFWFTLALVLMLVLMVPKLDSRQLTVLLDSEQRQGTMLEQHIEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
PANDLMWWRRLHRAIEKWAPPGQHLILVTSEGRIIGVQRQEVQMVRNFIGQSDNADQPKK
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVEMVGPFSIRDGEDNYQLYLIRPANSPQSDFINLMFDRPLLLLIATMLISAPLLL
HHCCCEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WLAWSLAKPARKLKNAADDVARGNLKQHPELESGPQEFLATGASFNQMISSLDRMVVAQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLISDISHELRTPLTRLQLATALMRRRHGEGKELERIEMEAQRLDSMINDLLVLSRSQHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELHREPIKADELWSDVLENAQFEAEQMGKTLVVTAPPGPWPLFCNPAALDSALENIVRN
HHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
ALRYSHHHIAVAFSIDNQGVTIIVDDDGPGVSPEDREQIFRPFYRTDEARDRASGGTGLG
HHHHCCCEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCHH
LAIVETAVSQHRGWVKAEDSPLGGLRLIVWLPLHPLKS
HHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]