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The map label for this gene is cytR [H]

Identifier: 170026308

GI number: 170026308

Start: 4533197

End: 4534225

Strand: Direct

Name: cytR [H]

Synonym: YPK_4101

Alternate gene names: 170026308

Gene position: 4533197-4534225 (Clockwise)

Preceding gene: 170026307

Following gene: 170026309

Centisome position: 96.67

GC content: 48.1

Gene sequence:

>1029_bases
TTGGAAAATAAGAAAGAATTCACAATGACCACGATGAAAGATGTTGCTGAAATGGCAGGTGTATCAACAGCAACCGTGTC
TCGCGCGTTGATGAACCCTGAAAAGGTTTCAACCGTGACCCGACAAAAAGTGGAACAAGCCGTTTTGGCTGTTGGTTATT
CTCCTCATGCTTTATCCCGTAATATTAAGCGTAATGAATCACGTACGATTCTGGTGATCGTACCCGATATCAGTGACCCA
TTTTTTGCCGATGTCATTCAGGGCATTGAACACGCAGCCGCCCAGCAAGGCTATCTGATATTAATTGGTGATTGCGCACA
ACAAACCCAGCAAGAGCGCACATTTGTTAATCTGATTATCACCAAACAGATCGATGGCATGCTGCTATTAGGCTCTAACC
TGCCTTTTGATGCCAGTAAAGAAGAGCAGCGAAATTTACCCCCGATGGTCATGGCGAATGAGTTTGCTCCTGAGTTGGAG
CTGCCGACCGTACATATCGATAACCTGACCGCCGCTTATGAAGCCGTTAACTATTTGCATGAGTTGGGCCATAAACGCAT
CGCCTGTATCGCCGGGCCAGAAAGCCTGCCGCTGAGCCATTATCGGTTACAAGGTTATATTCAGGCACTGCGTCGTAATG
GTATTACTGTCGATAATGACTATATTATACGCGGGGATTTCAGCTACGAAGCGGGGGCCCAAAGCTTTGCGGCTCTTATG
GAGCTGCCCCACCCCCCCACTGCAATATTTTCTCACAATGATGTCATGGCAGTAGGGGCTATCTGGCAGGCGAAGCAATT
AGGGTTACGTATCCCGCAGGATGTCTCGCTGGTTGGCTTTGATGACTTGAAGCTGTCACAGTTTTGTGACCCCCCATTAA
CTACCGTCGCACAACCCCGTTACCAGATTGGCCAGCAAGCCATGTTACTCTTACTGGAGCAACTGCAAGGGCATTCAGTA
CAAAGTGGCTCCCGCTTGTTAGATACCGAATTAATCATCAGGGAAAGTACTGCTGCGCCTAAACACTAG

Upstream 100 bases:

>100_bases
TGTATAGAATGACGGCAAGTCAGTATTTAACCGAAACAACACGGCCATAAAAGTCTATGAGCGCGCTTACTGGCTCGGAG
CTAGAGTAAGGAGAAGGGCG

Downstream 100 bases:

>100_bases
GCAAATATTCAAGGGTTCAGTAACATGACGGACTTATTCCATCATTACGACGCAGCGAAACGATTGTGGCACAAAGAGAT
TATGTAAGCCGAGGGCGCTC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MENKKEFTMTTMKDVAEMAGVSTATVSRALMNPEKVSTVTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDISDP
FFADVIQGIEHAAAQQGYLILIGDCAQQTQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAYEAVNYLHELGHKRIACIAGPESLPLSHYRLQGYIQALRRNGITVDNDYIIRGDFSYEAGAQSFAALM
ELPHPPTAIFSHNDVMAVGAIWQAKQLGLRIPQDVSLVGFDDLKLSQFCDPPLTTVAQPRYQIGQQAMLLLLEQLQGHSV
QSGSRLLDTELIIRESTAAPKH

Sequences:

>Translated_342_residues
MENKKEFTMTTMKDVAEMAGVSTATVSRALMNPEKVSTVTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDISDP
FFADVIQGIEHAAAQQGYLILIGDCAQQTQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAYEAVNYLHELGHKRIACIAGPESLPLSHYRLQGYIQALRRNGITVDNDYIIRGDFSYEAGAQSFAALM
ELPHPPTAIFSHNDVMAVGAIWQAKQLGLRIPQDVSLVGFDDLKLSQFCDPPLTTVAQPRYQIGQQAMLLLLEQLQGHSV
QSGSRLLDTELIIRESTAAPKH
>Mature_342_residues
MENKKEFTMTTMKDVAEMAGVSTATVSRALMNPEKVSTVTRQKVEQAVLAVGYSPHALSRNIKRNESRTILVIVPDISDP
FFADVIQGIEHAAAQQGYLILIGDCAQQTQQERTFVNLIITKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAYEAVNYLHELGHKRIACIAGPESLPLSHYRLQGYIQALRRNGITVDNDYIIRGDFSYEAGAQSFAALM
ELPHPPTAIFSHNDVMAVGAIWQAKQLGLRIPQDVSLVGFDDLKLSQFCDPPLTTVAQPRYQIGQQAMLLLLEQLQGHSV
QSGSRLLDTELIIRESTAAPKH

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=339, Percent_Identity=71.3864306784661, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=33.9339339339339, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=33.8323353293413, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=30.9309309309309, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=32.1212121212121, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789068, Length=336, Percent_Identity=30.0595238095238, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=29.5819935691318, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786540, Length=337, Percent_Identity=29.9703264094956, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787580, Length=315, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787906, Length=307, Percent_Identity=28.0130293159609, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790715, Length=316, Percent_Identity=25, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789456, Length=316, Percent_Identity=26.5822784810127, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786268, Length=313, Percent_Identity=22.6837060702875, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790689, Length=316, Percent_Identity=24.6835443037975, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37829; Mature: 37829

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKKEFTMTTMKDVAEMAGVSTATVSRALMNPEKVSTVTRQKVEQAVLAVGYSPHALSR
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHC
NIKRNESRTILVIVPDISDPFFADVIQGIEHAAAQQGYLILIGDCAQQTQQERTFVNLII
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHEEEEE
TKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAYEAVNYLH
EECCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHH
ELGHKRIACIAGPESLPLSHYRLQGYIQALRRNGITVDNDYIIRGDFSYEAGAQSFAALM
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEECCCCHHHHHHHHHHH
ELPHPPTAIFSHNDVMAVGAIWQAKQLGLRIPQDVSLVGFDDLKLSQFCDPPLTTVAQPR
HCCCCCCEEECCCCEEEEHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YQIGQQAMLLLLEQLQGHSVQSGSRLLDTELIIRESTAAPKH
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCC
>Mature Secondary Structure
MENKKEFTMTTMKDVAEMAGVSTATVSRALMNPEKVSTVTRQKVEQAVLAVGYSPHALSR
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHC
NIKRNESRTILVIVPDISDPFFADVIQGIEHAAAQQGYLILIGDCAQQTQQERTFVNLII
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHEEEEE
TKQIDGMLLLGSNLPFDASKEEQRNLPPMVMANEFAPELELPTVHIDNLTAAYEAVNYLH
EECCCCEEEECCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHH
ELGHKRIACIAGPESLPLSHYRLQGYIQALRRNGITVDNDYIIRGDFSYEAGAQSFAALM
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEECCCCHHHHHHHHHHH
ELPHPPTAIFSHNDVMAVGAIWQAKQLGLRIPQDVSLVGFDDLKLSQFCDPPLTTVAQPR
HCCCCCCEEECCCCEEEEHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YQIGQQAMLLLLEQLQGHSVQSGSRLLDTELIIRESTAAPKH
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]