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The map label for this gene is ilvC [H]

Identifier: 170026261

GI number: 170026261

Start: 4469193

End: 4470671

Strand: Reverse

Name: ilvC [H]

Synonym: YPK_4051

Alternate gene names: 170026261

Gene position: 4470671-4469193 (Counterclockwise)

Preceding gene: 170026263

Following gene: 170026260

Centisome position: 95.33

GC content: 50.37

Gene sequence:

>1479_bases
ATGGCTAACTATTTCAACACATTGAACCTGCGTCAGCAGTTGGCGCAATTAGGTAAGTGTCGCTTTATGGCACGTGACGA
ATTTGCCGATGAAGCCGGCTACCTGAAAGGCAAAAAAGTGGTGATTGTCGGTTGTGGCGCACAGGGCCTGAACCAAGGGT
TGAACATGCGTGACTCCGGCCTGGATGTCGCTTATGCCCTGCGTAAAGAAGCGATTGCCGAGAAGCGTGCTTCATGGCGT
AAAGCAACCGAAAATGGTTTCAAAGTAGGCACTTACGAAGAGTTGATCCCACAGGCGGATCTGGTGGTTAACCTGACGCC
AGACAAGCAGCACTCTGCCGTGGTTAAGGCGGTTCAGCCTCTGATGAAAGAGGGCGCAGCACTGGGTTACTCGCATGGTT
TCAACATTGTTGAAGTGGGTGAGCAAGTGCGTAAAGACATCACCGTGGTGATGGTTGCGCCGAAATGCCCTGGTACCGAA
GTTCGTGAAGAGTACAAACGTGGTTTTGGTGTGCCGACGCTGATTGCGGTTCATCCAGAAAACGACCCTAAAGGCGAAGG
CATGGCGATTGCTAAAGCCTGGGCCGCGGCCACCGGTGGTCACCGTGCGGGTGTACTGGAATCTTCTTTTGTTGCCGAAG
TGAAATCTGACCTGATGGGCGAGCAAACTATCCTGTGTGGTATGTTGCAGGCGGGTTCACTGTTATGTTTCGACAAGTTG
GTTTCAGAGGGTACTGATGCCGCTTACGCTGAAAAACTGATTCAATTCGGCTGGGAAACCATTACCGAAGCGCTGAAACA
AGGCGGGATCACGCTGATGATGGACCGTTTGTCTAATCCAGCAAAACTGCGTGCGTATGCATTATCTGAACAGTTGAAAG
AAATTATGGCGCCATTGTTCCAGAAACACATGGACGACATTATTTCTGGTGCGTTCTCCAGCGGCATGATGGCTGACTGG
GCTAACGATGACGTTAAGTTGTTGAACTGGCGTGAAGAGACCGGCAGAACGGCTTTTGAAAATGCGCCACAGTTTGAAGG
CAAGATCTCTGAGCAGGAATATTTTGACCACGGCGTACTGATGATCGCGATGGTAAAAGCGGGAGTTGAGCTGGCATTCG
AAACCATGGTGGATTCCGGCATTATTGAAGAGTCTGCTTACTACGAATCTCTGCACGAGCTGCCGTTGATTGCCAACACT
ATCGCCCGTAAGCGTCTGTATGAAATGAACGTGGTTATCTCTGATACCGCAGAATACGGTAACTACTTGTTTGCTAATGC
AGCGGTGCCGTTGCTGAAAGAGAAGTTTATGGATTCCCTGCAAGCCGGTGACCTGGGTAAAAGTATCCCTGGTTCGGCGG
TAGATAACGCACAACTGCGTGATGTGAATGAAGCCATTCGCAATCACCCGATCGAAGCCGTTGGTCATAAGCTGCGTGGT
TACATGACAGATATGAAGCGTATTGCTGTTGCGGGCTAA

Upstream 100 bases:

>100_bases
GCAGCCATAAAAATAGTCATTCGCTATAGCAAAAACGGCGCTGACAGGACTCAAAGTTACTGGCTGCAATCACCACATAA
AACACGAACGGAGTAATACC

Downstream 100 bases:

>100_bases
TAACCGACTTTAGTTTGTGATTTTATATTGAGCCTCCCTGTAAAAAGGGGGGCTTTTTTATGTGCACCTTAGCAGGCAAT
ACGTAAGGTAGAATTGCCGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASWR
KATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQPLMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSGMMADW
ANDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRG
YMTDMKRIAVAG

Sequences:

>Translated_492_residues
MANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASWR
KATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQPLMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSGMMADW
ANDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRG
YMTDMKRIAVAG
>Mature_491_residues
ANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASWRK
ATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQPLMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLV
SEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSGMMADWA
NDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTI
ARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRGY
MTDMKRIAVAG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=92.2764227642276, Blast_Score=918, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=286, Percent_Identity=32.1678321678322, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 53933; Mature: 53802

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQP
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
QKHMDDIISGAFSSGMMADWANDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHCCCHHCCCCCCCCCCCHHHHHHCHHH
MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRG
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
YMTDMKRIAVAG
HHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLRQQLAQLGKCRFMARDEFADEAGYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSAVVKAVQP
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKEGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
QKHMDDIISGAFSSGMMADWANDDVKLLNWREETGRTAFENAPQFEGKISEQEYFDHGVL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHCCCHHCCCCCCCCCCCHHHHHHCHHH
MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANAAVPLLKEKFMDSLQAGDLGKSIPGSAVDNAQLRDVNEAIRNHPIEAVGHKLRG
CEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
YMTDMKRIAVAG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA