Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 170026245

GI number: 170026245

Start: 4451596

End: 4451922

Strand: Reverse

Name: trxA [H]

Synonym: YPK_4035

Alternate gene names: 170026245

Gene position: 4451922-4451596 (Counterclockwise)

Preceding gene: 170026248

Following gene: 170026244

Centisome position: 94.94

GC content: 45.87

Gene sequence:

>327_bases
ATGAGCGATAAAATTATTCACCTGAGTGACGACAGTTTCGATACTGATGTGCTGAAAGCCAGTGGCTTGGTCTTAGTCGA
TTTCTGGGCTGAATGGTGTGGTCCGTGCAAGATGATTGCTCCGATTTTGGATGAAATCGCTGAAGAGTATGAAGGTAGAC
TGACTATCGCTAAATTGAACATTGATGATAATCAGGGCACAGCACCAAAATACGGTATCCGTGGGATTCCTACGCTACTG
TTGTTCCGTGATGGCGAAGTTGTCGCCACCAAGGTTGGTGCCTTGTCTAAGGGGCAACTCAAAGCGTTCTTGGATGCAAA
TCTGTAA

Upstream 100 bases:

>100_bases
CTAACTATTGCTTTACGAAAGCGTATCCGGTGAAATAAAGTCATCCTACTGTTGGTTAATGCTACACCAACGAGGTAGAC
ACAATCCTTTGGAGTAGAAC

Downstream 100 bases:

>100_bases
TCGGTGCTAGCCGTCTATACCCCAAGTCATTGGAGTAATGAGAGCCGCTAACACAGCGGTGGCCTCAAGGACGTAGGGTA
TGTTTAGCGGCAGTTGTGAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIIHLSDDSFDTDVLKASGLVLVDFWAEWCGPCKMIAPILDEIAEEYEGRLTIAKLNIDDNQGTAPKYGIRGIPTLL
LFRDGEVVATKVGALSKGQLKAFLDANL

Sequences:

>Translated_108_residues
MSDKIIHLSDDSFDTDVLKASGLVLVDFWAEWCGPCKMIAPILDEIAEEYEGRLTIAKLNIDDNQGTAPKYGIRGIPTLL
LFRDGEVVATKVGALSKGQLKAFLDANL
>Mature_107_residues
SDKIIHLSDDSFDTDVLKASGLVLVDFWAEWCGPCKMIAPILDEIAEEYEGRLTIAKLNIDDNQGTAPKYGIRGIPTLLL
FRDGEVVATKVGALSKGQLKAFLDANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=39.1304347826087, Blast_Score=80, Evalue=3e-16,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=40.6976744186046, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI42794771, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI224493972, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=87.037037037037, Blast_Score=199, Evalue=4e-53,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=35.7798165137615, Blast_Score=89, Evalue=5e-20,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=38.1443298969072, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=95, Percent_Identity=40, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509965, Length=77, Percent_Identity=42.8571428571429, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=96, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=35.2272727272727, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=82, Percent_Identity=37.8048780487805, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=39.2405063291139, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=79, Percent_Identity=39.2405063291139, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=74, Percent_Identity=31.0810810810811, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=31.0810810810811, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=82, Percent_Identity=45.1219512195122, Blast_Score=77, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=39.5348837209302, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=28.8888888888889, Blast_Score=60, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=41.25, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=35.8695652173913, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=35.632183908046, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17648013, Length=97, Percent_Identity=37.1134020618557, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=97, Percent_Identity=37.1134020618557, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=37.5, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=29.0322580645161, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11796; Mature: 11664

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIIHLSDDSFDTDVLKASGLVLVDFWAEWCGPCKMIAPILDEIAEEYEGRLTIAKLN
CCCCEEEECCCCCCCHHHHHCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEE
IDDNQGTAPKYGIRGIPTLLLFRDGEVVATKVGALSKGQLKAFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SDKIIHLSDDSFDTDVLKASGLVLVDFWAEWCGPCKMIAPILDEIAEEYEGRLTIAKLN
CCCEEEECCCCCCCHHHHHCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEE
IDDNQGTAPKYGIRGIPTLLLFRDGEVVATKVGALSKGQLKAFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]