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The map label for this gene is hemD [H]

Identifier: 170026228

GI number: 170026228

Start: 4429301

End: 4430050

Strand: Direct

Name: hemD [H]

Synonym: YPK_4017

Alternate gene names: 170026228

Gene position: 4429301-4430050 (Clockwise)

Preceding gene: 170026227

Following gene: 170026229

Centisome position: 94.45

GC content: 51.07

Gene sequence:

>750_bases
ATGACAATCCTGGTCACCCGTCCATCCCCTGCTGGGGAGCAATTAGTCACTCGCTTGCGTGCTCTGGGCCGGGTTGCCTA
CCATGCGCCATTGATTGATTTTTCCCCAGGAAGAGACCTGCCCAAACTGCCGGAATTATTGCAAGATATGCAAGCGGGAG
ACTTGGTTTTTGCTTTATCACAGAACGCGGTCCGCTACGCTAACCCGCTGTTAAAAAGAAATAAACTGTCATGGCCTGTG
CAGTTATCTTATTATGCTATTGGCCGTACAACCGCATTAGCACTGCATACCGCCAGCCGTTTGCATGTCACTTTCCCACC
AATGGGGGAGACCAGTGAAATGCTGCTATCATTGCCCCTGCTGCAAAATTTGGCCGGTAAAAAGGCACTGTTATTACGCG
GTAATGGGGGCCGGGAGTTGCTAGGCGCAAGCCTCGCAGAACGCGGAGCGGCCGTGACCTTCTGCGAATGCTATCAACGC
AGTCCCATCTATTATGATGGCAGCGAACAAAGTGCTCACTGGCAACGTGCCGGTGTTGATATTCTGGTGGTCACCAGCGG
CGAAATGTTACAACAGATCTATACTTTAGTTCCTGATTACTATCGTTCTTCCTGGTTACTGCGTTGCCGTTTAATCGTTG
TGAGTGATCGTTTAGCGGCCTTAGCCACCCAAATGGGGTGGACGGAGGTCCGGGTAGCAGAAAATGCCGATAATGACGCA
CTGATCCGTGCGTTACAAGACCTTCAATAA

Upstream 100 bases:

>100_bases
CGGCAGAGGCTGAGCAGATGGGCATTGAACTTGCCGATGAGTTGCTATCACGCGGCGCACGAGAAATCCTGGCGGCGGTT
TATCTGGATAATCCTGCGCG

Downstream 100 bases:

>100_bases
ACCTAAAACCTGACTTATGGGATGCCCAATATGACGGAACAAAATACCCCATCCGCACCAGTGGAAGAGCCAACCACTGC
GGTTGAGAGGCCCCAACAGC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALSQNAVRYANPLLKRNKLSWPV
QLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPLLQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQR
SPIYYDGSEQSAHWQRAGVDILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA
LIRALQDLQ

Sequences:

>Translated_249_residues
MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALSQNAVRYANPLLKRNKLSWPV
QLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPLLQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQR
SPIYYDGSEQSAHWQRAGVDILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA
LIRALQDLQ
>Mature_248_residues
TILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALSQNAVRYANPLLKRNKLSWPVQ
LSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPLLQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRS
PIYYDGSEQSAHWQRAGVDILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDAL
IRALQDLQ

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=60.9756097560976, Blast_Score=315, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27605; Mature: 27474

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALS
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEC
QNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPL
CCCHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHHH
LQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVD
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEHHHHHCCCCEEECCCCCCCHHHHCCCE
ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA
EEEEECHHHHHHHHHHCCHHHHCCHHHEEEEEEEHHHHHHHHHHCCCEEEEEECCCCCHH
LIRALQDLQ
HHHHHHHCC
>Mature Secondary Structure 
TILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEC
QNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPL
CCCHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCEEEEECCCCCCHHHHHHHHHH
LQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVD
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEHHHHHCCCCEEECCCCCCCHHHHCCCE
ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA
EEEEECHHHHHHHHHHCCHHHHCCHHHEEEEEEEHHHHHHHHHHCCCEEEEEECCCCCHH
LIRALQDLQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]