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The map label for this gene is xerC

Identifier: 170026220

GI number: 170026220

Start: 4421735

End: 4422646

Strand: Reverse

Name: xerC

Synonym: YPK_4009

Alternate gene names: 170026220

Gene position: 4422646-4421735 (Counterclockwise)

Preceding gene: 170026221

Following gene: 170026219

Centisome position: 94.31

GC content: 53.51

Gene sequence:

>912_bases
ATGACCGAGTTCAGTGCTTCACTGGCTCCGCAGGTAGAGGCTTTTCTCCGTTATCTCAGTATTGAGCGTCAACTTAGTCC
ACTGACCGTCACCAGTTATCGCCGTCAGTTGTCTGCGCTAATGGAAATAGGCGAACAGATGGGCTTGGCTCACTGGCAGA
CGCTGGATGCTGCTCAGGTCCGTTCGTTGGTCTCCCGCAGCAAACGTGCGGGTTTACATGCTTCAAGCCTGGCATTACGG
CTCTCCGCATTACGCAGTTTTCTCAACTGGTTGGTCAGCCAGGGCGTGCTGCCAGCCAACCCCGCTAAAGGGGTCAGTAC
GCCACGCTCGGGCCGCCACCTGCCAAAAAATATTGATGTTGATGAAGTCAATAAACTGCTGAGTATTGATCTGAATGATC
CGCTGGCGGTACGTGACCGGGCCATGCTGGAGGTGATGTACGGCGCGGGGCTGCGTTTATCTGAATTGGTTGGCATGAAC
TGTAAACATGTGGATCTGGCGAGCGGCGATGTCTGGGTGATGGGGAAGGGCAGTAAAGAGCGCAAGGTGCCGTTAGGTAA
AACGGCGGTGACCTGGTTACAGCATTGGCTGGCGTTACGTGAGTTATTCGAACCGCAAGATGACGCTATTTTTCTGGCCA
ATACCGGCAAGCGTATTTCAGCCCGTAATGTGCAGAAGCGCTTTGCCGAATGGGGGGTGAAGCAGGGGGTCAGTAGCCAC
ATTCACCCACATAAATTACGTCACTCTTTTGCCACGCACATGCTGGAATCCAGTGGTGATCTACGCGCAGTACAAGAGCT
ACTGGGCCATGCCAACCTGACCACCACGCAAATTTATACACATCTCGACTTTCAACATCTGGCGACAGTGTATGATGCTG
CTCATCCACGGGCCAAACGAGGCAAATCCTGA

Upstream 100 bases:

>100_bases
GCCGCGATGCTCAGCATTATCAACAAGGTATGGGGACGGTGATGTTAAACCAGCTATCCACATTGCTTCCGGGCCTCCTG
GCACGTTGGATCGAGCCGGT

Downstream 100 bases:

>100_bases
TGCATTTTTATCGTCCACTTGAGCGTATTTCCGCTATTACCTTCGATTTGGATGACACGTTGTACGACAATCGGCCAGTG
ATCGCGCGGACTGAACAGCA

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTEFSASLAPQVEAFLRYLSIERQLSPLTVTSYRRQLSALMEIGEQMGLAHWQTLDAAQVRSLVSRSKRAGLHASSLALR
LSALRSFLNWLVSQGVLPANPAKGVSTPRSGRHLPKNIDVDEVNKLLSIDLNDPLAVRDRAMLEVMYGAGLRLSELVGMN
CKHVDLASGDVWVMGKGSKERKVPLGKTAVTWLQHWLALRELFEPQDDAIFLANTGKRISARNVQKRFAEWGVKQGVSSH
IHPHKLRHSFATHMLESSGDLRAVQELLGHANLTTTQIYTHLDFQHLATVYDAAHPRAKRGKS

Sequences:

>Translated_303_residues
MTEFSASLAPQVEAFLRYLSIERQLSPLTVTSYRRQLSALMEIGEQMGLAHWQTLDAAQVRSLVSRSKRAGLHASSLALR
LSALRSFLNWLVSQGVLPANPAKGVSTPRSGRHLPKNIDVDEVNKLLSIDLNDPLAVRDRAMLEVMYGAGLRLSELVGMN
CKHVDLASGDVWVMGKGSKERKVPLGKTAVTWLQHWLALRELFEPQDDAIFLANTGKRISARNVQKRFAEWGVKQGVSSH
IHPHKLRHSFATHMLESSGDLRAVQELLGHANLTTTQIYTHLDFQHLATVYDAAHPRAKRGKS
>Mature_302_residues
TEFSASLAPQVEAFLRYLSIERQLSPLTVTSYRRQLSALMEIGEQMGLAHWQTLDAAQVRSLVSRSKRAGLHASSLALRL
SALRSFLNWLVSQGVLPANPAKGVSTPRSGRHLPKNIDVDEVNKLLSIDLNDPLAVRDRAMLEVMYGAGLRLSELVGMNC
KHVDLASGDVWVMGKGSKERKVPLGKTAVTWLQHWLALRELFEPQDDAIFLANTGKRISARNVQKRFAEWGVKQGVSSHI
HPHKLRHSFATHMLESSGDLRAVQELLGHANLTTTQIYTHLDFQHLATVYDAAHPRAKRGKS

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from xerD binding sites by a short central region, forming

COG id: COG4973

COG function: function code L; Site-specific recombinase XerC

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=296, Percent_Identity=72.6351351351351, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1789261, Length=299, Percent_Identity=38.7959866220736, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1790768, Length=162, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790767, Length=181, Percent_Identity=27.0718232044199, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_YERPE (Q8D1K0)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0468
- RefSeq:   NP_994495.1
- RefSeq:   YP_002348721.1
- ProteinModelPortal:   Q8D1K0
- SMR:   Q8D1K0
- IntAct:   Q8D1K0
- GeneID:   1176678
- GeneID:   2766754
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3843
- KEGG:   ypk:y0387
- KEGG:   ypm:YP_3204
- HOGENOM:   HBG727654
- OMA:   HAQGLGP
- ProtClustDB:   PRK00236
- BioCyc:   YPES187410:Y0387-MONOMER
- BioCyc:   YPES214092:YPO3843-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33731; Mature: 33600

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: ACT_SITE 152-152 ACT_SITE 176-176 ACT_SITE 244-244 ACT_SITE 247-247 ACT_SITE 270-270 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFSASLAPQVEAFLRYLSIERQLSPLTVTSYRRQLSALMEIGEQMGLAHWQTLDAAQV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHH
RSLVSRSKRAGLHASSLALRLSALRSFLNWLVSQGVLPANPAKGVSTPRSGRHLPKNIDV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
DEVNKLLSIDLNDPLAVRDRAMLEVMYGAGLRLSELVGMNCKHVDLASGDVWVMGKGSKE
HHHHHHEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCEEEEECCCCC
RKVPLGKTAVTWLQHWLALRELFEPQDDAIFLANTGKRISARNVQKRFAEWGVKQGVSSH
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
IHPHKLRHSFATHMLESSGDLRAVQELLGHANLTTTQIYTHLDFQHLATVYDAAHPRAKR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCC
GKS
CCC
>Mature Secondary Structure 
TEFSASLAPQVEAFLRYLSIERQLSPLTVTSYRRQLSALMEIGEQMGLAHWQTLDAAQV
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHH
RSLVSRSKRAGLHASSLALRLSALRSFLNWLVSQGVLPANPAKGVSTPRSGRHLPKNIDV
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
DEVNKLLSIDLNDPLAVRDRAMLEVMYGAGLRLSELVGMNCKHVDLASGDVWVMGKGSKE
HHHHHHEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCEEEEECCCCC
RKVPLGKTAVTWLQHWLALRELFEPQDDAIFLANTGKRISARNVQKRFAEWGVKQGVSSH
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
IHPHKLRHSFATHMLESSGDLRAVQELLGHANLTTTQIYTHLDFQHLATVYDAAHPRAKR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCC
GKS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430