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The map label for this gene is acs [H]

Identifier: 170026134

GI number: 170026134

Start: 4321256

End: 4323214

Strand: Direct

Name: acs [H]

Synonym: YPK_3921

Alternate gene names: 170026134

Gene position: 4321256-4323214 (Clockwise)

Preceding gene: 170026132

Following gene: 170026135

Centisome position: 92.15

GC content: 47.73

Gene sequence:

>1959_bases
ATGAGCCAAATACATAAACATCCTATTCCAGCTGCAATTGCAGAGCATGCTCTAATTACCCCAGAAAAATACCAACATTA
TTACCAACAATCAGTGCAGAACCCTGATGAATTCTGGGGCGAACAAGGCAAAATCATTGATTGGATTAAACCCTATAAAA
CGGTAAAAAATACCTCCTTTGACCCCGGTCATGTGAGTATCCGCTGGTTTGAGGACGGTACATTGAACCTCGCGGCGAAT
TGCCTTGATCGCCATTTGGCAGAGCGTGGTGATCAAACAGCCATCATTTGGGAAGGTGATGACCCTAATCAATCAAAAAC
CGTCACTTATAAGCAACTGCACCATGATGTGTGCCAGTTTGCTAATGTCCTAAAAAGTTTAGGCATCAAAAAAGGCGATG
TAGTTGCCATCTATATGCCAATGGTGCCTGAAGCTGCCGTGGCGATGTTGGCTTGCGCGCGCATTGGCGCTGTTCATTCC
GTTATCTTTGGTGGATTTTCTCCAGATGCCGTTGCCGGGCGTATCATCGATTCTCACTCTAAACTGGTGATTACTGCCGA
TGAAGGTATCCGTGCAGGCCGTGCTATTCCACTGAAAAAAAATGTTGATGAAGCACTGAAAAACCCCGCTATCACCAGTA
TTAAAAATGTTGTGGTCTTCCAACGTACTGGTAACGCCAGCTATTGGGAAGATGGGCGCGATGTATGGTGGCATGACCTG
ATAAAAGAGGCATCCGCTGACTGCCCGCCAGAAGAGATGAATGCAGAAGACCCGCTGTTCATCCTTTATACCTCTGGCTC
TACCGGTAAACCTAAAGGGGTTGTACATACGACGGGCGGTTATCTGGTTTACGCTGCACTGACATTCAAATATGTTTTTG
ATTATCACCCTGGCGATATCTACTGGTGTACTGCAGACGTTGGCTGGGTAACCGGGCACAGTTATCTATTATATGGACCA
CTGGCTTGTGGGGCCATCACTCTAATGTTTGAAGGCGTGCCTAACTACCCTGGCGTCAATCGCTTGAGCCAGGTTGTTGA
TAAACATAAAGTCAATATTCTATACACCGCGCCTACAGCGATTCGGGCCTTAATGGCCGAAGGTGACAAAGCCATCGGAG
GAACCAAACGCGACTCACTGCGTATTATGGGGTCGGTCGGCGAACCGATTAACCCAGAAGCCTGGGAATGGTATTACAAC
AAGATCGGTAACAGTAAATGCCCGATTGTCGATACCTGGTGGCAGACTGAAACCGGTGGTTTCATGATAACCCCTCTGCC
GGGTGCCACCGAGTTGAAAGCCGGTTCCGCAACTCGTCCATTCTTTGGGGTACAACCTGCGTTGGTAGATAACCTGGGCA
ATCCTCAGGAAGGGGTGGCAGAAGGTAATCTGGTCATAACCGACTCATGGCCGGGGCAAGCCAGAACATTATTTGGCGAT
CATGACCGTTTCGAGCAAACCTACTTCTCAACCTTTAAAGGCATGTATTTCAGTGGCGACGGCGCACGTCGTGACGAAGA
CGGTTACTACTGGATAACCGGTCGAGTCGATGACGTACTAAACGTTTCAGGCCATCGCTTAGGAACGGCTGAAATTGAAT
CTGCACTGGTTGCACACCCGAAAATTGCCGAAGCGGCTGTTGTCGGTGTTCCACATAATATTAAAGGACAGGCTATTTAT
GCCTATATCACGCTAAATCACGGTGAAGAACCAACTCCAGAGTTATATACCGAAGTACGCAACTGGGTACGTAAAGAGAT
TGGCCCACTTGCAACACCCGATATTTTGCATTGGACGGACTCATTACCCAAAACCCGTTCAGGCAAAATCATGCGCCGTA
TTTTACGCAAAATTGCGACAGGAGATACCAGCAACTTGGGCGATACCTCAACACTTGCCGATCCAAGCGTGGTAGAAAAA
TTACTAGAAGAAAAACAATCAATGCAGACACCGTCGTAA

Upstream 100 bases:

>100_bases
TTTATACGTGATCTGCCGCCCAAAAAAGAAACAAAACACTCTCCCATACTATAATTAACCTTTATTTGACATATTATTAA
CAACCTCAAGGAGAATGACG

Downstream 100 bases:

>100_bases
ATTGTGCCGCCTATATAGGCGGCAAACTTAATTGATGCCTCAAAGGAGAGACTCTGATGAATGACAGCATTTATCAAGAG
ATTGAAGATAATCCACGTTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIGGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEK
LLEEKQSMQTPS

Sequences:

>Translated_652_residues
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIGGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEK
LLEEKQSMQTPS
>Mature_651_residues
SQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSFDPGHVSIRWFEDGTLNLAANC
LDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQFANVLKSLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSV
IFGGFSPDAVAGRIIDSHSKLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDLI
KEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPL
ACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTAIRALMAEGDKAIGGTKRDSLRIMGSVGEPINPEAWEWYYNK
IGNSKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGDH
DRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGVPHNIKGQAIYA
YITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKL
LEEKQSMQTPS

Specific function: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=653, Percent_Identity=52.833078101072, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=666, Percent_Identity=51.8018018018018, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=633, Percent_Identity=48.9731437598736, Blast_Score=632, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.7952755905512, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=556, Percent_Identity=28.9568345323741, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI122937307, Length=559, Percent_Identity=28.0858676207513, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI38505220, Length=607, Percent_Identity=29.159802306425, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI31982927, Length=646, Percent_Identity=25.3869969040248, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI115511026, Length=571, Percent_Identity=28.1961471103327, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI58082049, Length=573, Percent_Identity=26.3525305410122, Blast_Score=166, Evalue=9e-41,
Organism=Homo sapiens, GI157311624, Length=573, Percent_Identity=25.4799301919721, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI157311622, Length=573, Percent_Identity=25.4799301919721, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI187761345, Length=404, Percent_Identity=28.2178217821782, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI187761343, Length=404, Percent_Identity=28.2178217821782, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=25.5707762557078, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI42544134, Length=373, Percent_Identity=25.7372654155496, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156151445, Length=386, Percent_Identity=27.2020725388601, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790505, Length=652, Percent_Identity=84.6625766871166, Blast_Score=1170, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=643, Percent_Identity=36.2363919129082, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=23.3962264150943, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788107, Length=581, Percent_Identity=24.6127366609294, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1786810, Length=548, Percent_Identity=22.0802919708029, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI145693145, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=668, Percent_Identity=48.8023952095808, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71982997, Length=649, Percent_Identity=49.1525423728814, Blast_Score=626, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17569507, Length=644, Percent_Identity=22.0496894409938, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=585, Percent_Identity=23.7606837606838, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=565, Percent_Identity=23.716814159292, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=579, Percent_Identity=24.1796200345423, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=550, Percent_Identity=22.1818181818182, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=546, Percent_Identity=22.7106227106227, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=537, Percent_Identity=20.1117318435754, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=637, Percent_Identity=48.9795918367347, Blast_Score=628, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=47.0219435736677, Blast_Score=596, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=25.531914893617, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667955, Length=654, Percent_Identity=53.822629969419, Blast_Score=706, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=56.2277580071174, Blast_Score=645, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.3461538461538, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=630, Percent_Identity=35.3968253968254, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI18859661, Length=531, Percent_Identity=25.2354048964218, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24656500, Length=527, Percent_Identity=21.6318785578748, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24581924, Length=555, Percent_Identity=21.0810810810811, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72000; Mature: 71869

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSF
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHCCCCC
DPGHVSIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANVLKSLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDAVAGRIIDSHS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCC
KLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
EEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHCEEEEEEEEECCCCCCCCCCCCHHHHHH
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDI
HHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHEEHHHHEEEECCCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIGGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNSKCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEECCC
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGVPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTD
CHHCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKLLEEKQSMQTPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQIHKHPIPAAIAEHALITPEKYQHYYQQSVQNPDEFWGEQGKIIDWIKPYKTVKNTSF
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHCCCCC
DPGHVSIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPNQSKTVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANVLKSLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPDAVAGRIIDSHS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCC
KLVITADEGIRAGRAIPLKKNVDEALKNPAITSIKNVVVFQRTGNASYWEDGRDVWWHDL
EEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHCEEEEEEEEECCCCCCCCCCCCHHHHHH
IKEASADCPPEEMNAEDPLFILYTSGSTGKPKGVVHTTGGYLVYAALTFKYVFDYHPGDI
HHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHEEHHHHEEEECCCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVVDKHKVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIGGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNSKCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNLGNPQEGVAEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEECCC
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGVPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPLATPDILHWTD
CHHCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVEKLLEEKQSMQTPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA