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The map label for this gene is gltP [H]

Identifier: 170026133

GI number: 170026133

Start: 4319085

End: 4320401

Strand: Reverse

Name: gltP [H]

Synonym: YPK_3920

Alternate gene names: 170026133

Gene position: 4320401-4319085 (Counterclockwise)

Preceding gene: 170026137

Following gene: 170026130

Centisome position: 92.13

GC content: 43.66

Gene sequence:

>1317_bases
ATGAAAAGTATAAAAATAAGTCTGGCATGGCAAATACTCATTGCACTGGTGTTAGGCATTTTGGTTGGCGCAGTTTTACA
TAATCAAATTGAATCCAGGGAATTGTTAGTTAGTAATATTCTGAGTCCAGCGGGCGATATATTTATCCGCTTAATTAAAA
TGATTGTTGTACCGATTGTTATTTCAACGTTAATTGTCGGTATTGCGGGGGTCGGTGATGCGAAGAAACTTGGCCGGATT
GGCCTAAAAACCATTATCTACTTTGAAGTTATCACCACGATTGCCATTATTATCGGTATCACTCTGGCGAATGTATTCCA
GCCGGGGGTGGGTATAGATATGTCTGCGCTAACCGTCGTTGATATCTCTCAGTATGAAAAAACCACTGAACAGGTGCAAA
GCGGTAGTCATAGTCTGGTTAGCACTATCTTGTCGCTGATCCCGGCCAATGTCTTTGCCTCAATGGCGAAAGGCGATATG
TTGCCGATTATTTTCTTCTCAGTGTTGTTTGGTTTAGGGCTGTCTTCATTGCCAAAAGAAACCAAAGAACCACTGTTGAA
TGTGTTCAAGGCTGTTTCTGAAAGCATGTTCAAAGTCACTCACATGATTATGCGTTATGCGCCTATCGGGGTGTTTGGCT
TGATCTCGGTGACTGTGGCTAACTTTGGTTTTGCCTCACTAATCCCTCTCGCGAAGTTAGTTATTCTGGTTTATGCCGCG
ATCCTGTTCTTTGCTTTGGTTATTCTGGGAACGGTAGCGAGATTATGTAAGCTGCGGATCTGGATATTGATTCGTATTTT
GAAAGATGAACTGATTTTGGCGTATTCCACTGCCAGTTCTGAGACAGTCTTACCGCGTATTATTGAGAAAATGGAAGCTT
ATGGCGCACCAAAAGCGATTACCAGCTTTGTGGTTCCAACGGGTTATTCATTCAACTTAGATGGCTCGACATTATATCAG
AGCATTGCGGCTATCTTCATTGCACAGTTATACGGAATCGAATTGTCTATTGGGCAAGAGATTATTTTGGTTCTGACATT
GATGGTGACCTCGAAAGGGATTGCTGGTGTACCAGGCGTCTCCTTCGTCGTATTACTGGCAACGTTGGGCAGTGTGGGTA
TTCCATTGGAAGGCCTGGCCTTCATTGCCGGTGTTGACCGTATTCTGGATATGGCCCGTACCGCGTTGAATGTGGTGGGT
AATGCATTGGCAGTATTGGTGATCGCCAAATGGGAAAATCAGTTTGACGATAAAAAAGCCAAGGCTTATGAAAAAGCGTT
GTTTGCAGCAGAGCAGACGCCAGCTAATCAAAGCTAA

Upstream 100 bases:

>100_bases
TATGTTCCATCAACTATAGCCCGTATTTAATGATTAAGTATTTTATTCTAGATGCTTAGTTTCTTGCATTTTATGGAATG
CTTTGAGGAATTCTTAGGGT

Downstream 100 bases:

>100_bases
TACGCTATGTTCTTAGTGCTACAGCCGCAGTATTAGCGATAGCCTGATGAGAATGTGACTTAGCGAATAGTCTCTACCCA
CTCCCCGTCAGCGTCAGACT

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESRELLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKALFAAEQTPANQS

Sequences:

>Translated_438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESRELLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKALFAAEQTPANQS
>Mature_438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESRELLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKALFAAEQTPANQS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=441, Percent_Identity=29.0249433106576, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI194239697, Length=492, Percent_Identity=28.4552845528455, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI40254478, Length=464, Percent_Identity=27.3706896551724, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI66773030, Length=454, Percent_Identity=29.5154185022026, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI21314632, Length=429, Percent_Identity=26.5734265734266, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI262359914, Length=395, Percent_Identity=27.5949367088608, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4827012, Length=289, Percent_Identity=31.4878892733564, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI5032093, Length=407, Percent_Identity=26.2899262899263, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI223468564, Length=277, Percent_Identity=28.158844765343, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI223468566, Length=277, Percent_Identity=28.5198555956679, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI301601644, Length=145, Percent_Identity=34.4827586206897, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790514, Length=437, Percent_Identity=80.7780320366133, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=39.9038461538462, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1788024, Length=409, Percent_Identity=25.1833740831296, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789473, Length=394, Percent_Identity=23.3502538071066, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71983106, Length=448, Percent_Identity=27.0089285714286, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=448, Percent_Identity=27.0089285714286, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=426, Percent_Identity=26.9953051643192, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=475, Percent_Identity=25.8947368421053, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=455, Percent_Identity=27.2527472527473, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=410, Percent_Identity=25.3658536585366, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=413, Percent_Identity=26.634382566586, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=27.7522935779816, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=27.7522935779816, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=27.7522935779816, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281360483, Length=483, Percent_Identity=24.4306418219462, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17137666, Length=483, Percent_Identity=24.4306418219462, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281360481, Length=483, Percent_Identity=24.4306418219462, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46922; Mature: 46922

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIKISLAWQILIALVLGILVGAVLHNQIESRELLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLIVGIAGVGDAKKLGRIGLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWENQFDDKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAYEKALFAAEQTPANQS
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSIKISLAWQILIALVLGILVGAVLHNQIESRELLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLIVGIAGVGDAKKLGRIGLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWENQFDDKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAYEKALFAAEQTPANQS
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]