Click here to switch to the map view.

The map label for this gene is lcrF [H]

Identifier: 170026127

GI number: 170026127

Start: 4311429

End: 4312136

Strand: Reverse

Name: lcrF [H]

Synonym: YPK_3914

Alternate gene names: 170026127

Gene position: 4312136-4311429 (Counterclockwise)

Preceding gene: 170026128

Following gene: 170026126

Centisome position: 91.95

GC content: 41.67

Gene sequence:

>708_bases
ATGAAGTCAATACAGTTTATTTTATTTCGGCAAGAGGGCGTATTACGCAGTGATGGCGAGCGCTATGTTATACCTGCGGG
AAAATTAGTGATTGCCGATGAGCAGGCCAGTGCCTCTGCGTTTGCAAACAGTGCCATCACCTCTATATTATGTTACCCAA
TAGATCTTTTTCCGATATATCAGGATTTAGCCAGAAGAACATTACCGTTGAATAAAGGCCATCTTCCTCATGCGGTAAAT
GATAAATATAAAGTGTTGCCAGCGAATGTTGAAATTATACAAGCTGCTGAAGAATTAATTAATATAGAGCGTGTTGCCTC
TCTGCGATTTCTTTATCTTTATTGTTTAGGTATCGATAACGTTTATTTTTCCAAGCTGTTGGACTCCATTGTGGGTACGA
ATAACGAACTACTTGAGTTTTTCGAAAAGAATCGGCTCAACCCATGGAGCGTTTCACGCTATGCCAATGAATTGGGTATT
TCGACCCGGAAATTGAATTTCCTGTTTTATGAGAAATTCGGCATGTCGGCGAAACAGTGGTTACTGGATCAGCGTTTGAA
AAAGGGCTGTGAGCTATTACTTTCGACCCGCTTACGGGTGGCTGATATTGCCATGGAGTGTGGTTTTAGTAATCACGCGC
ATTTCTCAGATAGCTTTCGTCGGCGCTTTCAACAATGCCCATCGCATATGCGTTCACTTATTGAATAG

Upstream 100 bases:

>100_bases
GTTTACTGTCTGATTATTCAGACTTCAGGTGAATACCGGATACGCATTGGCAGTATTATTGGTCAAACTGCATAAGATTA
ATTGTTCCCTAAGGAATATC

Downstream 100 bases:

>100_bases
GAGAGTTTGATGCAGATAAGTAGCCCAATGGGCCAATTGACAAACGATATTCAGCAGGCCAGACAGGCGTATCAGAACCA
AATGGCGGCAGTGAATATCA

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKSIQFILFRQEGVLRSDGERYVIPAGKLVIADEQASASAFANSAITSILCYPIDLFPIYQDLARRTLPLNKGHLPHAVN
DKYKVLPANVEIIQAAEELINIERVASLRFLYLYCLGIDNVYFSKLLDSIVGTNNELLEFFEKNRLNPWSVSRYANELGI
STRKLNFLFYEKFGMSAKQWLLDQRLKKGCELLLSTRLRVADIAMECGFSNHAHFSDSFRRRFQQCPSHMRSLIE

Sequences:

>Translated_235_residues
MKSIQFILFRQEGVLRSDGERYVIPAGKLVIADEQASASAFANSAITSILCYPIDLFPIYQDLARRTLPLNKGHLPHAVN
DKYKVLPANVEIIQAAEELINIERVASLRFLYLYCLGIDNVYFSKLLDSIVGTNNELLEFFEKNRLNPWSVSRYANELGI
STRKLNFLFYEKFGMSAKQWLLDQRLKKGCELLLSTRLRVADIAMECGFSNHAHFSDSFRRRFQQCPSHMRSLIE
>Mature_235_residues
MKSIQFILFRQEGVLRSDGERYVIPAGKLVIADEQASASAFANSAITSILCYPIDLFPIYQDLARRTLPLNKGHLPHAVN
DKYKVLPANVEIIQAAEELINIERVASLRFLYLYCLGIDNVYFSKLLDSIVGTNNELLEFFEKNRLNPWSVSRYANELGI
STRKLNFLFYEKFGMSAKQWLLDQRLKKGCELLLSTRLRVADIAMECGFSNHAHFSDSFRRRFQQCPSHMRSLIE

Specific function: Transcriptional activator of the thermally regulated virulent yopE gene. LcrF activity could be modulated by the interaction with an inducer molecule serving as a temperature messenger. The availability of the messenger would in turn be controlled by a te

COG id: COG2207

COG function: function code K; AraC-type DNA-binding domain-containing proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003313
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF02311 AraC_binding; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 27020; Mature: 27020

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIQFILFRQEGVLRSDGERYVIPAGKLVIADEQASASAFANSAITSILCYPIDLFPIY
CCCEEEEEEECCCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QDLARRTLPLNKGHLPHAVNDKYKVLPANVEIIQAAEELINIERVASLRFLYLYCLGIDN
HHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VYFSKLLDSIVGTNNELLEFFEKNRLNPWSVSRYANELGISTRKLNFLFYEKFGMSAKQW
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHEEEEHHHCCCHHHH
LLDQRLKKGCELLLSTRLRVADIAMECGFSNHAHFSDSFRRRFQQCPSHMRSLIE
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSIQFILFRQEGVLRSDGERYVIPAGKLVIADEQASASAFANSAITSILCYPIDLFPIY
CCCEEEEEEECCCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QDLARRTLPLNKGHLPHAVNDKYKVLPANVEIIQAAEELINIERVASLRFLYLYCLGIDN
HHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VYFSKLLDSIVGTNNELLEFFEKNRLNPWSVSRYANELGISTRKLNFLFYEKFGMSAKQW
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHEEEEHHHCCCHHHH
LLDQRLKKGCELLLSTRLRVADIAMECGFSNHAHFSDSFRRRFQQCPSHMRSLIE
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1624422; 9746557; 9748454; 11586360 [H]