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The map label for this gene is yiaY [H]

Identifier: 170026061

GI number: 170026061

Start: 4237533

End: 4238681

Strand: Direct

Name: yiaY [H]

Synonym: YPK_3848

Alternate gene names: 170026061

Gene position: 4237533-4238681 (Clockwise)

Preceding gene: 170026060

Following gene: 170026062

Centisome position: 90.36

GC content: 51.26

Gene sequence:

>1149_bases
ATGAGTTTCATGTTGGCACTACCGAAAATCAGCTTGCACGGCACGGGTGCAATCGGCGATATGGTTAAATTACTCAGTGA
CAAACAGTGGGGGAAAGCACTGATTGTTACTGACGGGCAACTGGTTGAACTCGGCTTATTGGACAGTTTATTCGCGGCGC
TGGCGCAGTATCAGTTACCTTACGGGCTGTTTGGGGAGGTATTCCCTAATCCAACAGAAGAGTTGGTCCAGGCCGGTTTT
GCCGCCTTTACCCAGCATCAATGTGACTATTTGATTGCCTTCGGTGGTGGCAGCCCCATTGATACCGCCAAAGCCATCAA
GATACTGACTGCCAATCCGGGGCCATCCACCGCTTATTCCGGTGTAGGTAAAGTCAAACAAACGGGTGTTCCGTTGATAG
CCATCAATACCACGGCAGGAACGGCGGCGGAATTGACCAGTAATGCGGTGATTATTGATAGCCAGCGACAAGTGAAGGAG
GTGATTATCGATACCAATCTCATCCCTGATATTGCGGTTGACGATCCCTCAGTAATGCTCAATATTCCCGCCAGTGTCAC
GGCGGCGACGGGGATGGATGCCCTTACCCACGCAGTCGAAGCGTATGTCTCGTTAGGTGCACATACGTTAACGGACCATT
CAGCGCTCGAATCAATCCGTCTTATCAGCCAATGGTTGCCATTAGCGGTCGCTGACGGCAAAAACCTACAAGCGCGCGAA
ATGATGGCATGTGGGCAATATTTGGCGGGTATGGCGTTTAACAGTGCTGGGCTAGGTTTGGTTCACGCACTGGCCCACCA
ACCGGGTGCCACACATAATCTTCCTCATGGCGTCTGCAATGCTATCTTGCTGCCGGTAATTGAAGAATATAATCGCCCGC
AGGCTACCCGCCGTTTTGCCCGAATTGCACAGGCAATGGGGGTAGACACTCAGGACATGAGTGATGAGCAAGCAAGTCAT
CAGGCGATAGCGGCCATTCGTCAGTTATCGCTGCAAGTTGGTATTCCTGCCGGGTTCTCCGCCTTAGGTATTGAGGAAAG
TGATATTGAAGGTTGGTTAGATAAAGCGCTGGCTGACCCTTGTGCTCCTTGTAACCCACGTTCTGCAGATCGGGAACAAA
TTCGCACACTGTACTTACAGGCACTTTAA

Upstream 100 bases:

>100_bases
TGTTACGCCGATGGCAGCGGCGCTGGACGCCTAATCCCCTCGATTAAAGCCCTGGCTAACGTCGGGGCGAATCATTTATG
CGTTATTTGAGGAGTACAGT

Downstream 100 bases:

>100_bases
GCGAGGGAATATGATGATACGTAAAGCGTTTGTTATGGCAGTAAATCCGGATGCCCATGCTGAATATCAGCGACGGCACA
CGCCAATCTGGCCAGAGCTG

Product: lactaldehyde reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAALAQYQLPYGLFGEVFPNPTEELVQAGF
AAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKE
VIIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASH
QAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL

Sequences:

>Translated_382_residues
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAALAQYQLPYGLFGEVFPNPTEELVQAGF
AAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKE
VIIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASH
QAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL
>Mature_381_residues
SFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAALAQYQLPYGLFGEVFPNPTEELVQAGFA
AFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYSGVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEV
IIDTNLIPDIAVDDPSVMLNIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQAREM
MACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFARIAQAMGVDTQDMSDEQASHQ
AIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADPCAPCNPRSADREQIRTLYLQAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=378, Percent_Identity=25.3968253968254, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=43.8829787234042, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1789163, Length=383, Percent_Identity=41.77545691906, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=38.9920424403183, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1787493, Length=369, Percent_Identity=33.0623306233062, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1789386, Length=367, Percent_Identity=28.3378746594005, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17537053, Length=407, Percent_Identity=28.7469287469287, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=370, Percent_Identity=41.0810810810811, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24657991, Length=390, Percent_Identity=26.1538461538462, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40385; Mature: 40254

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAALAQYQLP
CCCEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCC
YGLFGEVFPNPTEELVQAGFAAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYS
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
GVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEVIIDTNLIPDIAVDDPSVML
CCCCHHHCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEE
NIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFA
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
RIAQAMGVDTQDMSDEQASHQAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCCC
CAPCNPRSADREQIRTLYLQAL
CCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFMLALPKISLHGTGAIGDMVKLLSDKQWGKALIVTDGQLVELGLLDSLFAALAQYQLP
CCEEECCCEEECCCCHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCC
YGLFGEVFPNPTEELVQAGFAAFTQHQCDYLIAFGGGSPIDTAKAIKILTANPGPSTAYS
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
GVGKVKQTGVPLIAINTTAGTAAELTSNAVIIDSQRQVKEVIIDTNLIPDIAVDDPSVML
CCCCHHHCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCEEE
NIPASVTAATGMDALTHAVEAYVSLGAHTLTDHSALESIRLISQWLPLAVADGKNLQARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
MMACGQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIEEYNRPQATRRFA
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
RIAQAMGVDTQDMSDEQASHQAIAAIRQLSLQVGIPAGFSALGIEESDIEGWLDKALADP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCCC
CAPCNPRSADREQIRTLYLQAL
CCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]