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The map label for this gene is pdxA [H]

Identifier: 170025787

GI number: 170025787

Start: 3937273

End: 3938268

Strand: Direct

Name: pdxA [H]

Synonym: YPK_3572

Alternate gene names: 170025787

Gene position: 3937273-3938268 (Clockwise)

Preceding gene: 170025786

Following gene: 170025788

Centisome position: 83.96

GC content: 50.2

Gene sequence:

>996_bases
ATGCACAACCACAATAATCGTCTAGTGATCACCCCCGGCGAGCCCGCCGGGGTCGGGCCGGATTTAGCCATCGCTCTGGC
TCAACAGGATTGGCCTGTTGAGCTGGTAGTCTGCGCGGATCCAGCCTTGCTACTGGCCCGAGCCAGCCAACTTAATCTGC
CCCTACAATTGCGTGAGTACCAAGCTGATCAGCCTGCAATAGCACAGCAAGCAGGGTCACTGACTATTTTACCTGTAAAA
ACAGCCGTTAATGTTGTCCCTGGCAAGCTTGATGTCGGTAACAGTCACTATGTGGTTGAAACGTTAGCCAAGGCTTGTGA
TGGTGCAATCAGTGGTGAATTCGCTGCATTGGTCACGGGCCCGGTACAAAAAAGTATTATCAATGATGCCGGCATCCCCT
TCATTGGGCATACCGAATTCTTTGCTGACCGCAGCCACTGCCAGAGGGTGGTGATGATGCTGGCAACGGAAGAGTTGCGT
GTGGCTTTAGCGACCACCCACTTGCCATTATTGGCGGTGCCAGGTGCCATTACGCAAGCCAGCTTACATGAAGTGATCAC
CATCCTTGATAACGACCTAAAAACCAAGTTTGGCATTACTCAGCCACAAATTTATGTTTGTGGGCTTAATCCTCATGCTG
GCGAAGGGGGACATATGGGCCATGAAGAGATCGATACGATTATTCCTGCCCTGAATACACTACGCCAGCAAGGGATAAAC
CTCATTGGCCCACTACCAGCAGACACCCTGTTTCAGCCGAAATATCTGCAACATGCAGATGCCGTTCTCGCGATGTATCA
CGATCAGGGGCTGCCAGTATTGAAATATCAAGGGTTTGGCCGAGCAGTCAATATCACTCTCGGTTTGCCTTTTATCCGCA
CTTCTGTGGATCACGGTACCGCTTTAGAACTCGCCGCAACCGGTACTGCCGATGTTGGCAGTTTCATTACGGCATTAAAC
TTAGCCATCAAAATGATAAATAACAGCAATGAATAA

Upstream 100 bases:

>100_bases
GCGTACCGTATGCTCTTCAACCGTAAATTTGCTGAAGAAGCACAAACCTGGATGCAAGAGCAGCGTGCTGCTGCTTATGT
AAAAATTCTTGATGGTAGTA

Downstream 100 bases:

>100_bases
TAGAGTCCACCAAGGGCATTTTGCCCGCAAACGCTTTGGACAAAACTTTTTAAACGATCAGTTTGTCATCGACAGTATTG
TCTCCGCAATCCACCCAGTT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTILPVK
TAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELR
VALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGIN
LIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALN
LAIKMINNSNE

Sequences:

>Translated_331_residues
MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTILPVK
TAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELR
VALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGIN
LIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALN
LAIKMINNSNE
>Mature_331_residues
MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTILPVK
TAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELR
VALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGIN
LIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALN
LAIKMINNSNE

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=326, Percent_Identity=74.2331288343558, Blast_Score=490, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35240; Mature: 35240

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREY
CCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEEEHHC
QADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTG
CCCCCHHHHHCCCEEEEEEHHEHEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEC
PVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGAITQA
HHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHHEEEHHHCCCEEECCCCHHHH
SLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGIN
HHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGT
EECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCC
ALELAATGTADVGSFITALNLAIKMINNSNE
EEEEEECCCCHHHHHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREY
CCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEEEHHC
QADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTG
CCCCCHHHHHCCCEEEEEEHHEHEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEC
PVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGAITQA
HHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHHEEEHHHCCCEEECCCCHHHH
SLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGIN
HHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGT
EECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCC
ALELAATGTADVGSFITALNLAIKMINNSNE
EEEEEECCCCHHHHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA