Click here to switch to the map view.

The map label for this gene is coaE [H]

Identifier: 170025718

GI number: 170025718

Start: 3849857

End: 3850477

Strand: Direct

Name: coaE [H]

Synonym: YPK_3503

Alternate gene names: 170025718

Gene position: 3849857-3850477 (Clockwise)

Preceding gene: 170025717

Following gene: 170025719

Centisome position: 82.1

GC content: 46.7

Gene sequence:

>621_bases
ATGACCTATATTGTGGCTCTCACAGGTGGGATCGGTAGCGGAAAGAGTACGGTGGCAAATGCATTCGCCAATTTAGGTGT
GCCGTTGGTTGATGCTGATATTATTGCTCGTCAGGTTGTTGAACCAGGGACATCTGCACTAGCGGCCATTGCATCCCGTT
ATGGTGAAAATATTTTGCAGCAAGATGGCTCATTAAATAGAGCGGCATTGCGACAAAAAATTTTCAGTGAGCAACAAGAA
AAAGCATGGTTAAATTCACTGTTACACCCCCTTATTCAGCAGGAAACGCAACACCAATTAGCCGGTATTGATCAACCTTA
TGCCCTTTGGGTTGTGCCTCTACTGGTTGAAAATGGTTTACATCACCGGGCAGATCGTGTGTTAGTAGTCGACGTAACAC
CAGACATACAGCTCGCACGGACCATGGCGAGAGATGGTATTACACGCCAACAGGCAGAAAATATTTTGGCTTCACAGGTT
TCGCGGCAACAACGCTTGGCCTGTGCTGATGACATTATTGACAATAGCGGCGACCCGTTAATGATCGCCCAGCATGTTGC
CTCACTACACCATTGGTACTTAAAATTGGCAACTGCGGCCCAACAGGATCTACATCAATGA

Upstream 100 bases:

>100_bases
TTTACTGCGCCATACAGATAGAATGCATACCTTGGCTATGCCTTCGCCCAAGCTTTCAGATACAATTCTCCCATCCAATG
GCAGTACATAAGGCGAAGCA

Downstream 100 bases:

>100_bases
GTGACCTTACCTCAACAATACTTTTTGAACATCCGCTCAATGAAAAGATGCGCACTTGGCTAAGAATGGAGTTTTTATTA
CAACAGCTAGAAAGCCACCG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQE
KAWLNSLLHPLIQQETQHQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQV
SRQQRLACADDIIDNSGDPLMIAQHVASLHHWYLKLATAAQQDLHQ

Sequences:

>Translated_206_residues
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQE
KAWLNSLLHPLIQQETQHQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQV
SRQQRLACADDIIDNSGDPLMIAQHVASLHHWYLKLATAAQQDLHQ
>Mature_205_residues
TYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQEK
AWLNSLLHPLIQQETQHQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVS
RQQRLACADDIIDNSGDPLMIAQHVASLHHWYLKLATAAQQDLHQ

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=194, Percent_Identity=34.5360824742268, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI191252795, Length=194, Percent_Identity=34.5360824742268, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI110227607, Length=187, Percent_Identity=25.1336898395722, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI110227605, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI110227603, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI110227601, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI205277394, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786292, Length=198, Percent_Identity=65.1515151515152, Blast_Score=248, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17554944, Length=180, Percent_Identity=33.8888888888889, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320402, Length=194, Percent_Identity=36.0824742268041, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24644728, Length=179, Percent_Identity=34.0782122905028, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24658602, Length=181, Percent_Identity=29.2817679558011, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 22517; Mature: 22386

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQ
CEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QDGSLNRAALRQKIFSEQQEKAWLNSLLHPLIQQETQHQLAGIDQPYALWVVPLLVENGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
HHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVSRQQRLACADDIIDNSGDPL
CCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
MIAQHVASLHHWYLKLATAAQQDLHQ
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQ
EEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QDGSLNRAALRQKIFSEQQEKAWLNSLLHPLIQQETQHQLAGIDQPYALWVVPLLVENGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
HHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVSRQQRLACADDIIDNSGDPL
CCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
MIAQHVASLHHWYLKLATAAQQDLHQ
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]