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The map label for this gene is phoR [H]

Identifier: 170025492

GI number: 170025492

Start: 3582311

End: 3583627

Strand: Reverse

Name: phoR [H]

Synonym: YPK_3275

Alternate gene names: 170025492

Gene position: 3583627-3582311 (Counterclockwise)

Preceding gene: 170025493

Following gene: 170025491

Centisome position: 76.42

GC content: 48.75

Gene sequence:

>1317_bases
GTGTTAGAACGCTTATCATGGAAAACGCTGGCTTTAGAGCTGGCTCTTTTTTGTTTGCCTGCATTATTACTGGGGGCGTT
TGTTGGTTATCTCCCTTGGTTATTGCTGGTTTCAGTGGTCGCCGCGCTGACGTGGAACTTTTATAATCAACTCAAACTCT
CTCATTGGTTGTGGCTTGATCGCAGTATGACACCGCCGTCGGGGCGTTGGAGTTGGGAACCCCTATTTTACGGCTTATAT
CAGATGCAATTGCGCAACCGCAGGCGTCGGCGCGAACTGGCGCTCTTAATTAAGCGTTTTCGCAGTGGTGCAGAGTCACT
GCCTGATGCCGTGGTTATCACCACGGTTGATGGTAATATTTTCTGGTGTAATGGTTTAGCTCAACAATTGTTGGGGTTTC
GCTGGCCAGAGGATAATGGGCAGCATATTCTCAATTTATTGCGCTACCCGGAATTTAGCCAATATCTGCAACAACAAACG
TTTTCCCGCCCACTGACCTTGCAATTGAATAACGGTTACTACGTGGAGTTTCGCGTGATGCCTTATTCTGAAGGGCAGTT
ATTGATGGTGGCCCGTGATGTGACTCAAATGCGCCAGTTGGAAGGTGCAAGACGTAACTTTTTTGCCAACGTCAGCCATG
AATTACGTACGCCGCTGACGGTGCTGCAAGGCTATCTGGAAATGATGCATGACCAAGAGTTGGCCGGGCCGTTACGCGAT
AAAGCTTTGGGGACGATGCAAGAGCAGACTAAGCGTATGGATGGGCTGGTGAAGCAACTTTTGACATTATCACGTATCGA
AGCCGCACCAAATGTGGATTTAAATGAGCGGGTGGATATTCCGCTGATGTTGAAAATATTGCAGCATGAGGTACAGGCAC
TGAGCAATGGCCGCCATGAGATTACTTTCAGGGTTAACGATCAATTAAAGGTATTCGGTAACGAAGACCAACTGCGTAGC
GCGGTATCGAATCTGGTCTACAACGCTGTAAATCATACGCCTGAAGGGACGAAAATTGAGGTCTGCTGGCAACAAACACC
ACAAGGTGCTCAATTTCAAGTCAGCGACAACGGGCCGGGGATCCCTCCTGAGCATGTTCCTCGCCTTACGGAGCGCTTCT
ATCGGGTCGATAAAGCCCGGTCACGGCAAACGGGGGGCAGTGGGTTGGGGTTGGCAATCGTGAAACATGCTCTGAGTCAC
CATGATGCGCGTTTGGAGGTGATGAGTGAAATTGGTCTGGGTACCCGTTTTATTTTTACCTTACCGAACAGGTTGATTGT
TCCAACTGTTTTAGTCGAGAATGCAGTCAAATCTTAA

Upstream 100 bases:

>100_bases
GCTTGAAACTGATGGTCACGATAAAATGGTACAAACTGTCCGGGGAACTGGATACCGTTTCTCAACGCGCTACTGAGTTT
TCAGTGCCGGAGAATTCGTT

Downstream 100 bases:

>100_bases
GACGGTGCGGATAAAAGCCTAATGAAATGGGGAAAACTGGCGCTCTTAAATGTCATTTTATGGCATAGCTATACTGTTTT
TGCGCAATCAATAGCTTTAG

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLERLSWKTLALELALFCLPALLLGAFVGYLPWLLLVSVVAALTWNFYNQLKLSHWLWLDRSMTPPSGRWSWEPLFYGLY
QMQLRNRRRRRELALLIKRFRSGAESLPDAVVITTVDGNIFWCNGLAQQLLGFRWPEDNGQHILNLLRYPEFSQYLQQQT
FSRPLTLQLNNGYYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMHDQELAGPLRD
KALGTMQEQTKRMDGLVKQLLTLSRIEAAPNVDLNERVDIPLMLKILQHEVQALSNGRHEITFRVNDQLKVFGNEDQLRS
AVSNLVYNAVNHTPEGTKIEVCWQQTPQGAQFQVSDNGPGIPPEHVPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEVMSEIGLGTRFIFTLPNRLIVPTVLVENAVKS

Sequences:

>Translated_438_residues
MLERLSWKTLALELALFCLPALLLGAFVGYLPWLLLVSVVAALTWNFYNQLKLSHWLWLDRSMTPPSGRWSWEPLFYGLY
QMQLRNRRRRRELALLIKRFRSGAESLPDAVVITTVDGNIFWCNGLAQQLLGFRWPEDNGQHILNLLRYPEFSQYLQQQT
FSRPLTLQLNNGYYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMHDQELAGPLRD
KALGTMQEQTKRMDGLVKQLLTLSRIEAAPNVDLNERVDIPLMLKILQHEVQALSNGRHEITFRVNDQLKVFGNEDQLRS
AVSNLVYNAVNHTPEGTKIEVCWQQTPQGAQFQVSDNGPGIPPEHVPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEVMSEIGLGTRFIFTLPNRLIVPTVLVENAVKS
>Mature_438_residues
MLERLSWKTLALELALFCLPALLLGAFVGYLPWLLLVSVVAALTWNFYNQLKLSHWLWLDRSMTPPSGRWSWEPLFYGLY
QMQLRNRRRRRELALLIKRFRSGAESLPDAVVITTVDGNIFWCNGLAQQLLGFRWPEDNGQHILNLLRYPEFSQYLQQQT
FSRPLTLQLNNGYYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMHDQELAGPLRD
KALGTMQEQTKRMDGLVKQLLTLSRIEAAPNVDLNERVDIPLMLKILQHEVQALSNGRHEITFRVNDQLKVFGNEDQLRS
AVSNLVYNAVNHTPEGTKIEVCWQQTPQGAQFQVSDNGPGIPPEHVPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEVMSEIGLGTRFIFTLPNRLIVPTVLVENAVKS

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=427, Percent_Identity=73.3021077283372, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=38.2222222222222, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=30.9012875536481, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=32.4894514767932, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=29.1828793774319, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=207, Percent_Identity=34.7826086956522, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=394, Percent_Identity=23.8578680203046, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=28.6343612334802, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=29.4372294372294, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=261, Percent_Identity=28.735632183908, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=263, Percent_Identity=26.9961977186312, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=347, Percent_Identity=23.9193083573487, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=26.6968325791855, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=29.3577981651376, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790567, Length=351, Percent_Identity=23.6467236467236, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=26.890756302521, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=26.5682656826568, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=32.2115384615385, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=201, Percent_Identity=26.865671641791, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790300, Length=358, Percent_Identity=25.4189944134078, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50255; Mature: 50255

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKTLALELALFCLPALLLGAFVGYLPWLLLVSVVAALTWNFYNQLKLSHWLWLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
RSMTPPSGRWSWEPLFYGLYQMQLRNRRRRRELALLIKRFRSGAESLPDAVVITTVDGNI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCE
FWCNGLAQQLLGFRWPEDNGQHILNLLRYPEFSQYLQQQTFSRPLTLQLNNGYYVEFRVM
EEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEEEE
PYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMHDQELAGPLRD
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALGTMQEQTKRMDGLVKQLLTLSRIEAAPNVDLNERVDIPLMLKILQHEVQALSNGRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
ITFRVNDQLKVFGNEDQLRSAVSNLVYNAVNHTPEGTKIEVCWQQTPQGAQFQVSDNGPG
EEEEECCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCC
IPPEHVPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDARLEVMSEIGLGTRFIFT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEE
LPNRLIVPTVLVENAVKS
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLERLSWKTLALELALFCLPALLLGAFVGYLPWLLLVSVVAALTWNFYNQLKLSHWLWLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
RSMTPPSGRWSWEPLFYGLYQMQLRNRRRRRELALLIKRFRSGAESLPDAVVITTVDGNI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCE
FWCNGLAQQLLGFRWPEDNGQHILNLLRYPEFSQYLQQQTFSRPLTLQLNNGYYVEFRVM
EEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEEEE
PYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMHDQELAGPLRD
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALGTMQEQTKRMDGLVKQLLTLSRIEAAPNVDLNERVDIPLMLKILQHEVQALSNGRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
ITFRVNDQLKVFGNEDQLRSAVSNLVYNAVNHTPEGTKIEVCWQQTPQGAQFQVSDNGPG
EEEEECCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCC
IPPEHVPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDARLEVMSEIGLGTRFIFT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEE
LPNRLIVPTVLVENAVKS
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]